PMID- 32990851 OWN - NLM STAT- MEDLINE DCOM- 20210809 LR - 20210809 IS - 1573-8221 (Electronic) IS - 0007-4888 (Linking) VI - 169 IP - 5 DP - 2020 Sep TI - Immunohistological Detection of Active Satellite Cellsin Rat Dorsal Root Ganglia after Parenteral Administration of Lipopolysaccharide and during Aging. PG - 665-668 LID - 10.1007/s10517-020-04950-2 [doi] AB - Immunohistochemical reaction to glial fibrillar acid protein (GFAP) is widely used for identification of activated satellite cells in sensory ganglia. We used this marker in studies of satellite cells activation in dorsal root ganglia during aging and under conditions of experimental systemic inflammation: in young (4 months) and aged (18-19 months) rats and animals with experimental LPS-induced systemic inflammation. The number of GFAP(+) satellite cells increased significantly after parenteral injection of LPS and during aging, which can indicate similarity of mechanisms of reactive glial changes during aging and systemic inflammation. FAU - Kolos, E A AU - Kolos EA AD - Institute of Experimental Medicine, St. Petersburg, Russia. koloselena1984@yandex.ru. FAU - Korzhevskii, D E AU - Korzhevskii DE AD - Institute of Experimental Medicine, St. Petersburg, Russia. LA - eng PT - Journal Article DEP - 20200929 PL - United States TA - Bull Exp Biol Med JT - Bulletin of experimental biology and medicine JID - 0372557 RN - 0 (Glial Fibrillary Acidic Protein) RN - 0 (Lipopolysaccharides) SB - IM MH - Animals MH - Ganglia, Spinal/drug effects/*metabolism MH - Glial Fibrillary Acidic Protein/metabolism MH - Immunohistochemistry MH - Lipopolysaccharides/toxicity MH - Male MH - Neuroglia/*drug effects/*metabolism MH - Neurons/drug effects/metabolism MH - Parenteral Nutrition MH - Rats MH - Rats, Wistar MH - Satellite Cells, Skeletal Muscle/drug effects OTO - NOTNLM OT - aging OT - dorsal root ganglion OT - satellite cells OT - systemic inflammation EDAT- 2020/09/30 06:00 MHDA- 2021/08/10 06:00 CRDT- 2020/09/29 12:37 PHST- 2020/01/28 00:00 [received] PHST- 2020/09/30 06:00 [pubmed] PHST- 2021/08/10 06:00 [medline] PHST- 2020/09/29 12:37 [entrez] AID - 10.1007/s10517-020-04950-2 [pii] AID - 10.1007/s10517-020-04950-2 [doi] PST - ppublish SO - Bull Exp Biol Med. 2020 Sep;169(5):665-668. doi: 10.1007/s10517-020-04950-2. Epub 2020 Sep 29.