PMID- 32991033
OWN - NLM
STAT- MEDLINE
DCOM- 20211206
LR  - 20211214
IS  - 1744-9987 (Electronic)
IS  - 1744-9979 (Linking)
VI  - 25
IP  - 4
DP  - 2021 Aug
TI  - Use of angiotensin converting enzyme inhibitors in patients receiving therapeutic 
      plasma exchange with a centrifuge-based apheresis system.
PG  - 497-501
LID - 10.1111/1744-9987.13589 [doi]
AB  - Angiotensin-converting enzyme inhibitors (ACEi) are frequently used 
      antihypertensive medications with additional advantages such as reducing 
      proteinuria and cardiovascular events. ACEi are commonly held at least 24 hours 
      before a therapeutic plasma exchange (TPE) to reduce possibility of adverse 
      events (AEs) including adverse drug reactions (ADR). The objective of this study 
      was to determine if ACEi use increases the risk of ADR in patients receiving TPE 
      with a conventional centrifuge-based apheresis system. This is a retrospective 
      chart review study (n = 252; 52% male). Binary logistic regression was used to 
      analyze the association of ACEi use and AEs. Of 171 patients who had AE during 
      TPE, only 38 patients were taking ACEi. There was no significant association 
      between ACEi use and AEs after adjustments (odds ratio = 0.885, 95% confidence 
      interval: 0.468, 1.674). Our results suggest that risk of AEs is not higher in 
      patients taking ACEi receiving TPE using a centrifuge-based machine. Randomized 
      controlled prospective trials may be needed to further investigate this matter.
CI  - (c) 2020 International Society for Apheresis, Japanese Society for Apheresis, and 
      Japanese Society for Dialysis Therapy.
FAU - Jang, Soo Min
AU  - Jang SM
AD  - Department of Pharmacy Practice, Loma Linda University School of Pharmacy, Loma 
      Linda, California, USA.
FAU - Bahjri, Khaled
AU  - Bahjri K
AD  - Pharmaceutical and Administrative Sciences, Loma Linda University School of 
      Pharmacy, Loma Linda, California, USA.
FAU - Lee, Joanna
AU  - Lee J
AD  - Loma Linda University School of Pharmacy, Loma Linda, California, USA.
FAU - Nabavi, Sanaz
AU  - Nabavi S
AD  - California State University-Los Angeles, Los Angeles, California, USA.
FAU - Abdipour, Amir
AU  - Abdipour A
AUID- ORCID: 0000-0001-5204-1152
AD  - Department of Internal Medicine, Division of Nephrology, Loma Linda University 
      School of Medicine, Loma Linda, California, USA.
LA  - eng
PT  - Journal Article
DEP - 20201123
PL  - Australia
TA  - Ther Apher Dial
JT  - Therapeutic apheresis and dialysis : official peer-reviewed journal of the 
      International Society for Apheresis, the Japanese Society for Apheresis, the 
      Japanese Society for Dialysis Therapy
JID - 101181252
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
SB  - IM
MH  - Adult
MH  - Angiotensin-Converting Enzyme Inhibitors/adverse effects/*therapeutic use
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Plasma Exchange
MH  - Plasmapheresis/*methods
MH  - Retrospective Studies
OTO - NOTNLM
OT  - adverse events
OT  - angiotensin-converting enzyme inhibitor
OT  - centrifuge-based apheresis system
OT  - plasma exchange
EDAT- 2020/09/30 06:00
MHDA- 2021/12/15 06:00
CRDT- 2020/09/29 12:40
PHST- 2020/09/23 00:00 [revised]
PHST- 2020/06/20 00:00 [received]
PHST- 2020/09/26 00:00 [accepted]
PHST- 2020/09/30 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/09/29 12:40 [entrez]
AID - 10.1111/1744-9987.13589 [doi]
PST - ppublish
SO  - Ther Apher Dial. 2021 Aug;25(4):497-501. doi: 10.1111/1744-9987.13589. Epub 2020 
      Nov 23.