PMID- 32991476
OWN - NLM
STAT- MEDLINE
DCOM- 20201013
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 39
DP  - 2020 Sep 25
TI  - Clinical significance and influencing factors of fibrinogen in ANCA-associated 
      vasculitis: A single-center retrospective study from Southwest China.
PG  - e22424
LID - 10.1097/MD.0000000000022424 [doi]
LID - e22424
AB  - Hypercoagulable is an important pathological state in anti-neutrophil cytoplasmic 
      antibody-associated vasculitis (AAV). Fibrinogen (FIB) is the main protein in 
      coagulation process. In this study, we aimed to investigate the clinical 
      significance and influencing factors of FIB in AAV from Southwest China.A 
      retrospective study was performed on AAV patients from Peoples Hospital of Deyang 
      City from January 2007 to December 2018. Demographic and clinical characteristics 
      were collected.A total of 463 AAV patients were included. In Wilcoxon rank sum 
      test, FIB was significantly higher in AAV active group than inactive group 
      (P = .005). FIB was also higher in bacterial infection group than in 
      non-infection group both in active group (P = .008) and inactive group 
      (P = .017). In receiver operating characteristic (ROC) curve analysis, the 
      critical value of FIB for diagnosis of bacterial infection between AAV active and 
      inactive groups was 3.385 g/L (P = .030), with sensitivity of 70.2% and 
      specificity of 52.9%. In the multivariate analysis of variance (MANOVA), 
      estimated glomerular filtration rate (eGFR) was shown to be an independent factor 
      for FIB (P = .001). Least-significant difference showed the concentration of FIB 
      (P < .05) increased with renal impairment, especially in endstage kidney disease 
      (ESKD).FIB identified a certain reference value in distinguishing AAV activity 
      from bacterial infection. ESKD had a statistical effect on it. Influencing 
      factors of FIB should be evaluated based on the renal function impairment of 
      patients.
FAU - Zhang, Naidan
AU  - Zhang N
AD  - Department of Clinical Laboratory, Peoples Hospital of Deyang City, Deyang.
AD  - Department of Clinical Laboratory, West China Hospital of Sichuan University, 
      Chengdu.
FAU - Sun, Jiaxiang
AU  - Sun J
AD  - Department of Clinical Laboratory, Peoples Hospital of Deyang City, Deyang.
FAU - Ji, Chaixia
AU  - Ji C
AD  - Department of Clinical Laboratory, Peoples Hospital of Deyang City, Deyang.
FAU - Zhou, Yusha
AU  - Zhou Y
AD  - Department of Clinical Laboratory, Peoples Hospital of Deyang City, Deyang.
FAU - Bao, Xiao
AU  - Bao X
AD  - Department of Rheumatology, Peoples Hospital of Deyang City, Deyang, China.
FAU - Yuan, Chengliang
AU  - Yuan C
AUID- ORCID: 0000-0002-2187-3498
AD  - Department of Clinical Laboratory, Peoples Hospital of Deyang City, Deyang.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/*blood/complications/epidemiology
MH  - Bacterial Infections/*blood/complications
MH  - China/epidemiology
MH  - Female
MH  - Fibrinogen/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
PMC - PMC7523770
COIS- The authors declare that they have no competing interests.
EDAT- 2020/09/30 06:00
MHDA- 2020/10/21 06:00
PMCR- 2020/09/25
CRDT- 2020/09/29 17:13
PHST- 2020/09/29 17:13 [entrez]
PHST- 2020/09/30 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/09/25 00:00 [pmc-release]
AID - 00005792-202009250-00078 [pii]
AID - MD-D-20-01332 [pii]
AID - 10.1097/MD.0000000000022424 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Sep 25;99(39):e22424. doi: 
      10.1097/MD.0000000000022424.