PMID- 32991923 OWN - NLM STAT- MEDLINE DCOM- 20210419 LR - 20210419 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 192 DP - 2021 Jan TI - Intrauterine exposure to per- and polyfluoroalkyl substances may harm children's lung function development. PG - 110178 LID - S0013-9351(20)31075-6 [pii] LID - 10.1016/j.envres.2020.110178 [doi] AB - BACKGROUND: Per- and polyfluoroalkyl substances (PFAS), such as perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA), are common persistent environmental organic pollutants. Animal studies have indicated that PFAS influence inflammatory responses and lung development. However, whether prenatal or childhood PFAS exposure affects children's lung function remains unclear. This study aimed to investigate both in utero exposure and childhood exposure to PFAS and the relationships between them and lung function development in childhood. METHODS: In total, 165 children were recruited from the Taiwan Birth Panel Study (TBPS). Cord blood plasma and children's serum were collected when they were eight years old. PFAS levels were analysed by ultra-high-performance liquid chromatography/tandem mass spectrometry. When these children reached eight years of age, we administered detailed questionnaires and lung function examinations. RESULTS: The mean concentrations of PFOA, PFOS, PFNA and PFUA in cord blood among the 165 study children were 2.4, 6.4, 6.0, and 15.4 ng/mL, respectively. The mean concentrations in serum from eight-year-olds were 2.7, 5.9, 0.6, and 0.3 ng/mL, respectively. At eight years of age, the mean FEV1 (forced expiratory volume per sec), FVC (forced vital capacity), PEF (peak expiratory flow) and FEV1/FVC values were 1679 mL, 1835 mL, 3846 mL/s and 92.0%, respectively. PFOA, PFOS, PFNA and PFUA levels in cord blood were inversely associated with FEV1, FVC and PEF values. The PFOS concentration in cord blood was the most consistently correlated with decreasing lung function before and after adjusting for confounding factors. The PFOS concentration was also significantly inversely correlated with lung function in subgroups with lower birth weight and allergic rhinitis. CONCLUSIONS: Our cohort study revealed that the concentrations of PFOA, PFOS, PFNA and PFUA were higher in cord blood than in serum from eight-year-olds. Some trends were also noted between intrauterine PFOS exposure and children's decreasing FEV1, FVC and PEF, especially in subgroups with lower birth weight and allergic rhinitis. Therefore, intrauterine PFAS exposure, especially PFOS, may play a vital role in lung development. CI - Copyright (c) 2020 Elsevier Inc. All rights reserved. FAU - Kung, Yen-Ping AU - Kung YP AD - Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan. FAU - Lin, Ching-Chun AU - Lin CC AD - Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan. FAU - Chen, Mei-Huei AU - Chen MH AD - Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. FAU - Tsai, Meng-Shan AU - Tsai MS AD - Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan. FAU - Hsieh, Wu-Shiun AU - Hsieh WS AD - Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan. Electronic address: hsiehws@ntu.edu.tw. FAU - Chen, Pau-Chung AU - Chen PC AD - Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Innovation and Policy Center for Population Health and Sustainable Environment, National Taiwan University College of Public Health, Taipei, Taiwan. Electronic address: pchen@ntu.edu.tw. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200928 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 0 (Alkanesulfonic Acids) RN - 0 (Environmental Pollutants) RN - 0 (Fluorocarbons) SB - IM MH - *Alkanesulfonic Acids MH - Animals MH - Birth Weight MH - Child MH - Cohort Studies MH - *Environmental Pollutants/toxicity MH - Female MH - Fetal Blood MH - *Fluorocarbons/toxicity MH - Humans MH - Lung MH - Pregnancy MH - Taiwan OTO - NOTNLM OT - Allergic disease OT - Lung development OT - Lung function OT - Prenatal exposure OT - per- and polyfluoroalkyl substances EDAT- 2020/09/30 06:00 MHDA- 2021/04/20 06:00 CRDT- 2020/09/29 20:08 PHST- 2020/03/28 00:00 [received] PHST- 2020/09/02 00:00 [revised] PHST- 2020/09/02 00:00 [accepted] PHST- 2020/09/30 06:00 [pubmed] PHST- 2021/04/20 06:00 [medline] PHST- 2020/09/29 20:08 [entrez] AID - S0013-9351(20)31075-6 [pii] AID - 10.1016/j.envres.2020.110178 [doi] PST - ppublish SO - Environ Res. 2021 Jan;192:110178. doi: 10.1016/j.envres.2020.110178. Epub 2020 Sep 28.