PMID- 32992289
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20220531
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 196
DP  - 2020 Dec
TI  - Reduction-triggered di-block copolymer prodrug for high-performance long-acting 
      tumor-selective killing.
PG  - 111368
LID - S0927-7765(20)30724-4 [pii]
LID - 10.1016/j.colsurfb.2020.111368 [doi]
AB  - Long-acting drug delivery systems (DDSs) have attracted interests for tumor 
      chemotherapy. Here, novel reduction-triggered polymer prodrug was designed by 
      conjugation of a high-performance thiolated doxorubicin (DOX-SH) onto the diblock 
      copolymer PEG(43)-PPDSM(43)via the bioreducible cleavable disulfide bond. The 
      resultant polymer prodrug PEG(43)-PPDSM(43)-DOX with a DOX content of 33 % could 
      be easily self-assembled into nanoparticles of 146 nm. They showed a slow 
      solubility-controlled sustained drug release with a cumulative release of 30.13 % 
      within 84 h in the simulated tumor intracellular microenvironment but an 
      ultra-low premature drug leakage of 4.01 % in the simulated normal physiological 
      media. Such slow sustained release is expected to prolong the action time of the 
      active drug. The MTT assays demonstrated the tumor-selective killing performance 
      of the proposed prodrug nanoparticles with an enhanced antitumor efficacy on the 
      tumor HepG2 cells than the free DOX, but no obvious cytotoxicity on the normal 
      L20 cells at the lower dosages.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Dong, Yuman
AU  - Dong Y
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
FAU - Liu, Peng
AU  - Liu P
AD  - State Key Laboratory of Applied Organic Chemistry, College of Chemistry and 
      Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic 
      address: pliu@lzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200921
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Polymers)
RN  - 0 (Prodrugs)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Doxorubicin/pharmacology
MH  - Drug Delivery Systems
MH  - Drug Liberation
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - *Nanoparticles
MH  - *Neoplasms/drug therapy
MH  - Polymers
MH  - *Prodrugs/pharmacology
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Long-acting prodrug
OT  - Reduction-triggered drug delivery
OT  - Solubility-controlled release
OT  - Tumor-selective killing
OT  - Tumor-specific
EDAT- 2020/09/30 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/09/29 20:16
PHST- 2020/07/21 00:00 [received]
PHST- 2020/08/27 00:00 [revised]
PHST- 2020/08/29 00:00 [accepted]
PHST- 2020/09/30 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/09/29 20:16 [entrez]
AID - S0927-7765(20)30724-4 [pii]
AID - 10.1016/j.colsurfb.2020.111368 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2020 Dec;196:111368. doi: 
      10.1016/j.colsurfb.2020.111368. Epub 2020 Sep 21.