PMID- 32992892 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20231112 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 9 IP - 10 DP - 2020 Sep 25 TI - Inter- and Intra-Rater Reliability of Individual Cerebral Blood Flow Measured by Quantitative Vessel-Flow Phase-Contrast MRI. LID - 10.3390/jcm9103099 [doi] LID - 3099 AB - Vessel flow quantification by two-dimensional (2D) phase-contrast magnetic resonance imaging (PC-MRI) using a three-dimensional (3D) magnetic resonance angiography (MRA) model to measure cerebral blood flow has unclear analytical reliability. The present study aimed to determine the inter- and intra-rater reliability of quantitative vessel-flow PC-MRI and potential factors influencing its consistency. We prospectively recruited 30 Asian participants (aged 20-90 years; 16 women; 22 healthy and 8 stroke patients) for performing 1.5-T MR equipped with a head coil. Each participant was first scanned for time-of-flight magnetic resonance angiography (TOF-MRA) images for localization of intracranial arteries. The 2D PC-MRI for each cerebral artery (total 13 arteries in fixed order) was performed twice by two well-trained operators in optimal position. Using the same 3D MRA as a map and facilitated with the non-invasive optimal vessel analysis (NOVA) system, each scan was taken on a plane perpendicular to the target artery. Two consecutive full 13-artery scans were performed at least 15 min apart after participants were removed from the scanner table and then repositioned. A total of four PC flow images obtained from each target artery were transmitted to a workstation facilitated with the NOVA system. Flow data were calculated semi-automatically by the NOVA system after a few simple steps. Two-way mixed-effect models and standard errors of measurements were used. In 13 cerebral arteries, repeatability, using the intra-rater estimate expressed as the average-measures intraclass correlation coefficient, ranged from 0.641 to 0.954, and reproducibility, using the inter-rater estimate, ranged from 0.672 to 0.977. Except in the middle cerebral artery and the distal segment of the anterior cerebral artery, repeatability and reproducibility were excellent (intraclass correlation coefficient exceeded 0.8). The use of quantitative vessel-flow PC-MRI is a precise means to measure blood flow in most target cerebral arteries. This was evidenced by inter-rater and intra-rater correlations that were good/excellent, indicating good reproducibility and repeatability. FAU - Chang, Kwang-Hwa AU - Chang KH AD - Department of Physical Medicine and Rehabilitation, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan. AD - Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. AD - Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei 110, Taiwan. FAU - Lee, Yuan-Hao AU - Lee YH AUID- ORCID: 0000-0002-2058-3317 AD - Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan. FAU - Chen, Chia-Yuen AU - Chen CY AD - Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan. AD - Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. FAU - Lin, Ming-Fang AU - Lin MF AD - Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan. AD - Department of Medical Imaging and Radiological Technology, Yuanpei University, Hsinchu 30015, Taiwan. FAU - Lin, Ying Chin AU - Lin YC AUID- ORCID: 0000-0001-8322-6336 AD - Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan. AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. FAU - Chen, Jyh-Horng AU - Chen JH AD - Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan. AD - Neurobiology and Cognitive Science Center, National Taiwan University, Taipei 10051, Taiwan. FAU - Chan, Wing P AU - Chan WP AD - Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan. AD - Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. LA - eng GR - #107-wf-swf-09/Inter-agency Research Fund, Wan Fang Hospital, Taipei Medical University/ PT - Journal Article DEP - 20200925 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC7601288 OTO - NOTNLM OT - blood flow OT - magnetic resonance imaging OT - quantitative imaging OT - repeatability OT - reproducibility COIS- The authors declare no competing financial and/or non-financial interests. EDAT- 2020/10/01 06:00 MHDA- 2020/10/01 06:01 PMCR- 2020/09/25 CRDT- 2020/09/30 01:02 PHST- 2020/08/18 00:00 [received] PHST- 2020/09/17 00:00 [revised] PHST- 2020/09/21 00:00 [accepted] PHST- 2020/09/30 01:02 [entrez] PHST- 2020/10/01 06:00 [pubmed] PHST- 2020/10/01 06:01 [medline] PHST- 2020/09/25 00:00 [pmc-release] AID - jcm9103099 [pii] AID - jcm-09-03099 [pii] AID - 10.3390/jcm9103099 [doi] PST - epublish SO - J Clin Med. 2020 Sep 25;9(10):3099. doi: 10.3390/jcm9103099.