PMID- 32992922
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 10
DP  - 2020 Sep 25
TI  - Salivary Cytokine Profile as a Possible Predictor of Autism Spectrum Disorder.
LID - 10.3390/jcm9103101 [doi]
LID - 3101
AB  - Autism spectrum disorder (ASD) is characterized by neurodevelopmental disorders 
      and alterations in immune function and cytokine levels. The aim of this study is 
      to determine the salivary levels of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), 
      interleukin-8 (IL-8), tumor necrosis factor alpha (TNFalpha), monocyte chemoattractant 
      protein-1 (MCP-1), Regulated on Activation, Normal T-cell Expressed and Secreted 
      (RANTES), and Eotaxin in children with ASD and in healthy controlsto assess their 
      predictive potential. We explored correlations between the cytokine levels and 
      the neurodevelopmental disorders related to ASD. The study comprised 19 children 
      with ASD and 19 typically developing (TD) ones. We analyzed salivary levels of 
      IL-1beta, IL-6, IL-8, TNFalpha, MCP-1, RANTES, and eotaxin on Luminex with 
      custom-designed 7-plex kits. The level of RANTES in ASD children was 
      significantly lower than those of TD. In TDs, the salivary levels of IL-1beta, 
      MCP-1, and TNFalpha correlated positively with age. In ASD, the cytokine levels did 
      not correlate with age. There were statistically significant differences between 
      the RANTES level and aggression and gait disturbances, between IL-8 level and 
      fixations/stimulations, and between IL-1beta level and no active speech. The levels 
      of the cytokine detected can manifest both systemic and local changes related to 
      ASD. The cytokine pattern cannot be used as a sole ASD predictor, but the 
      salivary levels may be helpful in categorizing the ASD subtype.
FAU - Samborska-Mazur, Joanna
AU  - Samborska-Mazur J
AD  - Department of Oral Surgery and Periodontology, Poznan University of Medical 
      Sciences, Bukowska 70 Street, 60812 Poznan, Poland.
FAU - Kostiukow, Anna
AU  - Kostiukow A
AUID- ORCID: 0000-0001-9782-0619
AD  - Department of Rheumatology, Rehabilitation and Internal Diseases, Poznan 
      University of Medical Sciences, 28 Czerwca 1956 135 Street, 61545 Poznan, Poland.
FAU - Miechowicz, Izabela
AU  - Miechowicz I
AUID- ORCID: 0000-0003-0751-4867
AD  - Department of Computer Science and Statistics, Poznan University of Medical 
      Sciences, Rokietnicka 7 Street, 60806 Poznan, Poland.
FAU - Sikorska, Dorota
AU  - Sikorska D
AD  - Department of Rheumatology, Rehabilitation and Internal Diseases, Poznan 
      University of Medical Sciences, 28 Czerwca 1956 135 Street, 61545 Poznan, Poland.
FAU - Rutkowski, Rafal
AU  - Rutkowski R
AD  - Department of Pathophysiology, Poznan University of Medical Sciences, Rokietnicka 
      8 Street, 60806 Poznan, Poland.
FAU - Wyganowska-Swiatkowska, Marzena
AU  - Wyganowska-Swiatkowska M
AD  - Department of Oral Surgery and Periodontology, Poznan University of Medical 
      Sciences, Bukowska 70 Street, 60812 Poznan, Poland.
FAU - Blochowiak, Katarzyna
AU  - Blochowiak K
AD  - Department of Oral Surgery and Periodontology, Poznan University of Medical 
      Sciences, Bukowska 70 Street, 60812 Poznan, Poland.
LA  - eng
GR  - 502-14-22123310-11263/Poznan University of Medical Sciences/
PT  - Journal Article
DEP - 20200925
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7601503
OTO - NOTNLM
OT  - RANTES
OT  - autism
OT  - autism spectrum disorder
OT  - eotaxin
OT  - neurodevelopmental disorders
OT  - saliva
OT  - salivary cytokines
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/01 06:00
MHDA- 2020/10/01 06:01
PMCR- 2020/09/25
CRDT- 2020/09/30 01:02
PHST- 2020/07/28 00:00 [received]
PHST- 2020/09/18 00:00 [revised]
PHST- 2020/09/21 00:00 [accepted]
PHST- 2020/09/30 01:02 [entrez]
PHST- 2020/10/01 06:00 [pubmed]
PHST- 2020/10/01 06:01 [medline]
PHST- 2020/09/25 00:00 [pmc-release]
AID - jcm9103101 [pii]
AID - jcm-09-03101 [pii]
AID - 10.3390/jcm9103101 [doi]
PST - epublish
SO  - J Clin Med. 2020 Sep 25;9(10):3101. doi: 10.3390/jcm9103101.