PMID- 32993033 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201103 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 9 IP - 10 DP - 2020 Sep 25 TI - Latilactobacillus curvatus: A Candidate Probiotic with Excellent Fermentation Properties and Health Benefits. LID - 10.3390/foods9101366 [doi] LID - 1366 AB - Latilactobacillus curvatus is a candidate probiotic that has been included in the list of recommended biological agents for certification by the European Food Safety Authority. According to the published genomic information, L. curvatus has several genes that encode metabolic pathways of carbohydrate utilization. In addition, there are some differences in cell surface complex related genes of L. curvatus from different sources. L. curvatus also has several genes that encode bacteriocin production, which can produce Curvacin A and Sakacin P. Due to its ability to produce bacteriocin, it is often used as a bioprotective agent in fermented meat products, to inhibit the growth of a variety of pathogenic and spoilage bacteria. L. curvatus exerts some probiotic effects, such as mediating the production of IL-10 by dendritic cells through NF-kappaB and extracellular regulated protein kinases (ERK) signals to relieve colitis in mice. This review is the first summary of the genomic and biological characteristics of L. curvatus. Our knowledge on its role in the food industry and human health is also discussed, with the aim of providing a theoretical basis for the development of applications of L. curvatus. FAU - Chen, Ying AU - Chen Y AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. FAU - Yu, Leilei AU - Yu L AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - International Joint Research Laboratory for Probiotics, Jiangnan University, Wuxi 214122, China. FAU - Qiao, Nanzhen AU - Qiao N AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. FAU - Xiao, Yue AU - Xiao Y AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. FAU - Tian, Fengwei AU - Tian F AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - International Joint Research Laboratory for Probiotics, Jiangnan University, Wuxi 214122, China. FAU - Zhao, Jianxin AU - Zhao J AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China. FAU - Zhang, Hao AU - Zhang H AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China. AD - National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China. FAU - Chen, Wei AU - Chen W AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China. AD - National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China. AD - Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University, Beijing 100048, China. FAU - Zhai, Qixiao AU - Zhai Q AD - State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - School of Food Science and Technology, Jiangnan University, Wuxi 214122, China. AD - International Joint Research Laboratory for Probiotics, Jiangnan University, Wuxi 214122, China. LA - eng GR - BK20180603/Natural Science Foundation of Jiangsu Province/ GR - 31530056, 31772090, 31820103010, U1903205/National Natural Science Foundation of China/ PT - Journal Article PT - Review DEP - 20200925 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC7600897 OTO - NOTNLM OT - Latilactobacillus curvatus OT - beneficial function OT - fermentation properties OT - probiotic candidate COIS- The authors declare no conflict of interest. EDAT- 2020/10/01 06:00 MHDA- 2020/10/01 06:01 PMCR- 2020/09/25 CRDT- 2020/09/30 01:02 PHST- 2020/08/24 00:00 [received] PHST- 2020/09/18 00:00 [revised] PHST- 2020/09/21 00:00 [accepted] PHST- 2020/09/30 01:02 [entrez] PHST- 2020/10/01 06:00 [pubmed] PHST- 2020/10/01 06:01 [medline] PHST- 2020/09/25 00:00 [pmc-release] AID - foods9101366 [pii] AID - foods-09-01366 [pii] AID - 10.3390/foods9101366 [doi] PST - epublish SO - Foods. 2020 Sep 25;9(10):1366. doi: 10.3390/foods9101366.