PMID- 32995116
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2198-3844 (Print)
IS  - 2198-3844 (Electronic)
IS  - 2198-3844 (Linking)
VI  - 7
IP  - 17
DP  - 2020 Sep
TI  - HGF Mediates Clinical-Grade Human Umbilical Cord-Derived Mesenchymal Stem Cells 
      Improved Functional Recovery in a Senescence-Accelerated Mouse Model of 
      Alzheimer's Disease.
PG  - 1903809
LID - 10.1002/advs.201903809 [doi]
LID - 1903809
AB  - Stem cells have emerged as a potential therapy for a range of neural insults, but 
      their application in Alzheimer's disease (AD) is still limited and the mechanisms 
      underlying the cognitive benefits of stem cells remain to be elucidated. Here, 
      the effects of clinical-grade human umbilical cord-derived mesenchymal stem cells 
      (hUC-MSCs) on the recovery of cognitive ability in SAMP8 mice, a 
      senescence-accelerated mouse model of AD is explored. A functional assay 
      identifies that the core functional factor hepatocyte growth factor (HGF) 
      secreted from hUC-MSCs plays critical roles in hUC-MSC-modulated recovery of 
      damaged neural cells by down-regulating hyperphosphorylated tau, reversing spine 
      loss, and promoting synaptic plasticity in an AD cell model. Mechanistically, 
      structural and functional recovery, as well as cognitive enhancements elicited by 
      exposure to hUC-MSCs, are at least partially mediated by HGF in the AD 
      hippocampus through the activation of the cMet-AKT-GSK3beta signaling pathway. Taken 
      together, these data strongly implicate HGF in mediating hUC-MSC-induced 
      improvements in functional recovery in AD models.
CI  - (c) 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Jia, Yali
AU  - Jia Y
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
AD  - Experimental Hematology and Biochemistry Lab Beijing Institute of Radiation 
      Medicine Beijing 100850 China.
AD  - South China Institute of Biomedicine Guangzhou 510005 China.
FAU - Cao, Ning
AU  - Cao N
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
AD  - 920th Hospital of Joint Logistics Support Force Kunming 650032 China.
FAU - Zhai, Jinglei
AU  - Zhai J
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
FAU - Zeng, Quan
AU  - Zeng Q
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
AD  - South China Institute of Biomedicine Guangzhou 510005 China.
FAU - Zheng, Pei
AU  - Zheng P
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
FAU - Su, Ruyu
AU  - Su R
AD  - South China Institute of Biomedicine Guangzhou 510005 China.
FAU - Liao, Tuling
AU  - Liao T
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
FAU - Liu, Jiajing
AU  - Liu J
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
FAU - Pei, Haiyun
AU  - Pei H
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
AD  - Experimental Hematology and Biochemistry Lab Beijing Institute of Radiation 
      Medicine Beijing 100850 China.
FAU - Fan, Zeng
AU  - Fan Z
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
AD  - South China Institute of Biomedicine Guangzhou 510005 China.
FAU - Zhou, Junnian
AU  - Zhou J
AD  - Experimental Hematology and Biochemistry Lab Beijing Institute of Radiation 
      Medicine Beijing 100850 China.
AD  - South China Institute of Biomedicine Guangzhou 510005 China.
FAU - Xi, Jiafei
AU  - Xi J
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
AD  - South China Institute of Biomedicine Guangzhou 510005 China.
FAU - He, Lijuan
AU  - He L
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
AD  - South China Institute of Biomedicine Guangzhou 510005 China.
FAU - Chen, Lin
AU  - Chen L
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
AD  - South China Institute of Biomedicine Guangzhou 510005 China.
FAU - Nan, Xue
AU  - Nan X
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
AD  - South China Institute of Biomedicine Guangzhou 510005 China.
FAU - Yue, Wen
AU  - Yue W
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
AD  - South China Institute of Biomedicine Guangzhou 510005 China.
FAU - Pei, Xuetao
AU  - Pei X
AUID- ORCID: 0000-0002-2896-6021
AD  - Stem Cell and Regenerative Medicine Lab Institute of Health Service and 
      Transfusion Medicine Beijing 100850 China.
AD  - South China Institute of Biomedicine Guangzhou 510005 China.
LA  - eng
PT  - Journal Article
DEP - 20200706
PL  - Germany
TA  - Adv Sci (Weinh)
JT  - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
JID - 101664569
PMC - PMC7507104
OTO - NOTNLM
OT  - AKT-GSK3beta signaling pathway
OT  - Alzheimer's disease
OT  - cMet
OT  - hepatocyte growth factor
OT  - hyperphosphorylated tau
OT  - umbilical cord-derived mesenchymal stem cells
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/01 06:00
MHDA- 2020/10/01 06:01
PMCR- 2020/07/06
CRDT- 2020/09/30 06:13
PHST- 2019/12/30 00:00 [received]
PHST- 2020/06/04 00:00 [revised]
PHST- 2020/09/30 06:13 [entrez]
PHST- 2020/10/01 06:00 [pubmed]
PHST- 2020/10/01 06:01 [medline]
PHST- 2020/07/06 00:00 [pmc-release]
AID - ADVS1922 [pii]
AID - 10.1002/advs.201903809 [doi]
PST - epublish
SO  - Adv Sci (Weinh). 2020 Jul 6;7(17):1903809. doi: 10.1002/advs.201903809. 
      eCollection 2020 Sep.