PMID- 32995705
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 2512-9465 (Electronic)
IS  - 2567-3459 (Print)
IS  - 2512-9465 (Linking)
VI  - 4
IP  - 3
DP  - 2020 Jul
TI  - COVID-19-Induced Cytokine Release Syndrome Associated with Pulmonary Vein 
      Thromboses, Atrial Cardiomyopathy, and Arterial Intima Inflammation.
PG  - e271-e279
LID - 10.1055/s-0040-1716717 [doi]
AB  - Coronavirus disease 2019 (COVID-19) is a viral disease induced by severe acute 
      respiratory syndrome-coronavirus-2 (SARS-CoV-2), which may cause an acute 
      respiratory distress syndrome (ARDS). First reports have shown that elevated 
      levels of inflammatory cytokines might be involved in the development of organ 
      dysfunction in COVID-19. Here, we can present a case of cytokine release syndrome 
      induced by SARS-CoV-2 causing multiorgan failure and death. Of note, we can 
      report on pulmonary vein thromboses as potential source of cerebrovascular 
      embolic events. Furthermore, we present a specific form of an isolated 
      inflammatory atrial cardiomyopathy encompassing atrial myocardium, perivascular 
      matrix, as well as atrial autonomic nerve ganglia, causing atrial fibrillation, 
      sinus node arrest, as well as atrial clot formation in the right atrial 
      appendage. An associated acute glomerulonephritis caused acute kidney failure. 
      Furthermore, all the described pathologies of organs and vessels were associated 
      with increased local expression of interleukin-6 and monocyte chemoattractant 
      protein-1 (MCP-1). This report provides new evidence about fatal pathologies and 
      summarizes the current knowledge about organ manifestations observed in COVID-19.
FAU - Goette, Andreas
AU  - Goette A
AD  - Department of Cardiology and Intensive Care Medicine, St. Vincenz Hospital, 
      Paderborn, Germany.
AD  - Working Group: Molecular Electrophysiology, University Hospital Magdeburg, 
      Magdeburg, Germany.
FAU - Patscheke, Markus
AU  - Patscheke M
AD  - Department of Cardiology and Intensive Care Medicine, St. Vincenz Hospital, 
      Paderborn, Germany.
FAU - Henschke, Frank
AU  - Henschke F
AD  - Center for Pathology, Paderborn, Germany.
FAU - Hammwohner, Matthias
AU  - Hammwohner M
AD  - Department of Cardiology and Intensive Care Medicine, St. Vincenz Hospital, 
      Paderborn, Germany.
LA  - eng
PT  - Case Reports
DEP - 20200926
PL  - Germany
TA  - TH Open
JT  - TH open : companion journal to thrombosis and haemostasis
JID - 101715740
PMC - PMC7519876
OTO - NOTNLM
OT  - COVID19
OT  - atria
OT  - fibrillation
OT  - pathology
OT  - stroke
COIS- Conflict of Interest A.G. Speaker fees from Abbott, Astra Zeneca, Bayer Health 
      Care, Berlin Chemie, Biotronik, Boehringer Ingelheim, BMS/Pfizer, Boston 
      Scientific, Daiichi-Sankyo, Medtronic, and Omeicos. M.H. speaker fees from Astra 
      Zeneca, Bayer Health Care, Berlin Chemie, Boehringer Ingelheim, BMS/Pfizer, 
      Daiichi-Sankyo, and Medtronic. M.P. und F.H. have no conflicts of interest.
EDAT- 2020/10/01 06:00
MHDA- 2020/10/01 06:01
PMCR- 2020/09/26
CRDT- 2020/09/30 06:16
PHST- 2020/06/22 00:00 [received]
PHST- 2020/08/11 00:00 [accepted]
PHST- 2020/09/30 06:16 [entrez]
PHST- 2020/10/01 06:00 [pubmed]
PHST- 2020/10/01 06:01 [medline]
PHST- 2020/09/26 00:00 [pmc-release]
AID - 200045 [pii]
AID - 10.1055/s-0040-1716717 [doi]
PST - epublish
SO  - TH Open. 2020 Sep 26;4(3):e271-e279. doi: 10.1055/s-0040-1716717. eCollection 
      2020 Jul.