PMID- 32996789
OWN - NLM
STAT- MEDLINE
DCOM- 20211018
LR  - 20211018
IS  - 1532-7914 (Electronic)
IS  - 0163-5581 (Linking)
VI  - 73
IP  - 10
DP  - 2021
TI  - Evaluation of Inhibitory Effects of Caffeine on Human Carcinoma Cells.
PG  - 1998-2002
LID - 10.1080/01635581.2020.1819344 [doi]
AB  - One of the world's most consumed medications is caffeine which is available in 
      the vast majority of beverages. Previously, some effects of caffeine have been 
      evaluated including its inhibitory effect on cancer cells. But, the influence of 
      caffeine on esophagus carcinoma squamous cells (CSC) and head and neck carcinoma 
      cells still has not well understood. Herein, the relation between different 
      amounts of caffeine with the proliferation rate of human esophagus carcinoma 
      squamous cell line KYSE-30 as well as human head and neck carcinoma cell line HN5 
      was evaluated. Furthermore, concentrations of caffeine were adjusted and their 
      effect on cells were studied. The inhibitory effects of caffeine on cells were 
      measured using the conventional colorimetric MTT assay after 3 and 7 day of 
      incubation. Our findings are suggested that caffeine has a significant inhibitory 
      effect on both cell lines at the concentrations of 20, 50, and 70 milli-mol 
      (mmol). The result shows that caffeine can prevent the proliferation of carcinoma 
      cells and it is a perfect candidate for therapeutic applications.
FAU - Tonkaboni, Arghavan
AU  - Tonkaboni A
AD  - Department of Oral and Maxillofacial Medicine, School of Dentistry, Tehran 
      University of Medical Sciences, Tehran, Iran.
FAU - Lotfibakhshaiesh, Nasrin
AU  - Lotfibakhshaiesh N
AD  - Department of Tissue Engineering and Applied Cell Sciences, School of Advanced 
      Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Danesh, Pariya
AU  - Danesh P
AD  - School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Tajerian, Roksana
AU  - Tajerian R
AD  - Department of Modern Sciences and Technologies, School of Medicine, Mashhad 
      University of Medical Sciences, Iran.
FAU - Ziaei, Heliya
AU  - Ziaei H
AD  - School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200930
PL  - United States
TA  - Nutr Cancer
JT  - Nutrition and cancer
JID - 7905040
RN  - 3G6A5W338E (Caffeine)
SB  - IM
MH  - Caffeine/pharmacology
MH  - *Carcinoma, Squamous Cell
MH  - Cell Line, Tumor
MH  - *Esophageal Neoplasms
MH  - *Head and Neck Neoplasms/drug therapy
MH  - Humans
EDAT- 2020/10/01 06:00
MHDA- 2021/10/21 06:00
CRDT- 2020/09/30 12:12
PHST- 2020/10/01 06:00 [pubmed]
PHST- 2021/10/21 06:00 [medline]
PHST- 2020/09/30 12:12 [entrez]
AID - 10.1080/01635581.2020.1819344 [doi]
PST - ppublish
SO  - Nutr Cancer. 2021;73(10):1998-2002. doi: 10.1080/01635581.2020.1819344. Epub 2020 
      Sep 30.