PMID- 32998300 OWN - NLM STAT- MEDLINE DCOM- 20210414 LR - 20210414 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 12 IP - 10 DP - 2020 Sep 28 TI - Therapeutic Potential of beta-Caryophyllene: A Dietary Cannabinoid in Diabetes and Associated Complications. LID - 10.3390/nu12102963 [doi] LID - 2963 AB - Diabetes mellitus (DM), a metabolic disorder is one of the most prevalent chronic diseases worldwide across developed as well as developing nations. Hyperglycemia is the core feature of the type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), following insulin deficiency and impaired insulin secretion or sensitivity leads insulin resistance (IR), respectively. Genetic and environmental factors attributed to the pathogenesis of DM and various therapeutic strategies are available for the prevention and treatment of T2DM. Among the numerous therapeutic approaches, the health effects of dietary/nutraceutical approach due to the presence of bioactive constituents, popularly termed phytochemicals are receiving special interest for pharmacological effects and therapeutic benefits. The phytochemicals classes, in particular sesquiterpenes received attention because of potent antioxidant, anti-inflammatory, and antihyperglycemic effects and health benefits mediating modulation of enzymes, receptors, and signaling pathways deranged in DM and its complications. One of the terpene compounds, beta-caryophyllene (BCP), received enormous attention because of its abundant occurrence, non-psychoactive nature, and dietary availability through consumption of edible plants including spices. BCP exhibit selective full agonism on cannabinoid receptor type 2 (CB2R), an important component of endocannabinoid system, and plays a role in glucose and lipid metabolism and represents the newest drug target for chronic inflammatory diseases. BCP also showed agonist action on peroxisome proliferated activated receptor subtypes, PPAR-alpha and PPAR-gamma, the main target of currently used fibrates and imidazolidinones for dyslipidemia and IR, respectively. Many studies demonstrated its antioxidant, anti-inflammatory, organoprotective, and antihyperglycemic properties. In the present review, the plausible therapeutic potential of BCP in diabetes and associated complications has been comprehensively elaborated based on experimental and a few clinical studies available. Further, the pharmacological and molecular mechanisms of BCP in diabetes and its complications have been represented using synoptic tables and schemes. Given the safe status, abundant natural occurrence, oral bioavailability, dietary use and pleiotropic properties modulating receptors and enzymes, BCP appears as a promising molecule for diabetes and its complications. FAU - Hashiesh, Hebaallah Mamdouh AU - Hashiesh HM AUID- ORCID: 0000-0002-7777-8262 AD - Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, UAE. FAU - Meeran, Mohamed F Nagoor AU - Meeran MFN AD - Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, UAE. FAU - Sharma, Charu AU - Sharma C AD - Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, UAE. FAU - Sadek, Bassem AU - Sadek B AUID- ORCID: 0000-0002-0320-1487 AD - Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, UAE. AD - Zayed Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, UAE. FAU - Kaabi, Juma Al AU - Kaabi JA AUID- ORCID: 0000-0003-2477-0408 AD - Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, UAE. FAU - Ojha, Shreesh K AU - Ojha SK AD - Department of Pharmacology & Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, UAE. AD - Zayed Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, UAE. LA - eng GR - 31R127/College of Medicine and Health Sciences, United Arab Emirates University/ PT - Journal Article PT - Review DEP - 20200928 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Anti-Inflammatory Agents) RN - 0 (Antioxidants) RN - 0 (Cannabinoid Receptor Agonists) RN - 0 (Hypoglycemic Agents) RN - 0 (Phytochemicals) RN - 0 (Polycyclic Sesquiterpenes) RN - BHW853AU9H (caryophyllene) SB - IM MH - Animals MH - Anti-Inflammatory Agents/pharmacokinetics MH - Antioxidants/pharmacokinetics MH - Biological Availability MH - Cannabinoid Receptor Agonists/*pharmacokinetics MH - Diabetes Mellitus/*therapy MH - Diet/methods MH - Humans MH - Hypoglycemic Agents/pharmacokinetics MH - Phytochemicals/*pharmacokinetics MH - Polycyclic Sesquiterpenes/*pharmacokinetics PMC - PMC7599522 OTO - NOTNLM OT - diabetes OT - essential oils OT - hyperglycemia OT - inflammation OT - insulin resistance OT - natural products OT - oxidative stress OT - sesquiterpenes OT - beta-caryophyllene COIS- The authors hereby declare that there is no competing and conflict of interest. EDAT- 2020/10/02 06:00 MHDA- 2021/04/15 06:00 PMCR- 2020/10/01 CRDT- 2020/10/01 01:00 PHST- 2020/07/03 00:00 [received] PHST- 2020/08/14 00:00 [revised] PHST- 2020/09/01 00:00 [accepted] PHST- 2020/10/01 01:00 [entrez] PHST- 2020/10/02 06:00 [pubmed] PHST- 2021/04/15 06:00 [medline] PHST- 2020/10/01 00:00 [pmc-release] AID - nu12102963 [pii] AID - nutrients-12-02963 [pii] AID - 10.3390/nu12102963 [doi] PST - epublish SO - Nutrients. 2020 Sep 28;12(10):2963. doi: 10.3390/nu12102963.