PMID- 32998441
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201103
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 12
IP  - 10
DP  - 2020 Sep 28
TI  - Interleukin-18 and Hematopoietic Recovery after Allogeneic Stem Cell 
      Transplantation.
LID - 10.3390/cancers12102789 [doi]
LID - 2789
AB  - Interleukin-18 (IL-18) is an immunoregulatory cytokine and a context-dependent 
      regulator of hematopoietic stem/progenitor cell (HSPC) quiescence in murine 
      models. In a previous study, high pre-conditioning levels of IL-18 were 
      associated with increased non-relapse mortality (NRM) after allogeneic stem cell 
      transplantation (alloSCT). To investigate the clinical impact of IL-18 status on 
      hematopoietic function, the associations of pre-conditioning and day 0-3 cytokine 
      levels with platelet and neutrophil recovery were analyzed in a training cohort 
      of 714 allografted patients. In adjusted logistic regression analyses, both 
      increasing pre-conditioning and day 0-3 IL-18 levels had a significantly higher 
      adjusted odds ratio (aOR) of delayed platelet and neutrophil recovery on day +28 
      post-transplant (aOR per two-fold increase: 1.6-2.0). The adverse impact of high 
      pre-conditioning IL-18 on day +28 platelet recovery was verified in an 
      independent cohort of 673 allografted patients (aOR per two-fold increase: 1.8 
      and 1.7 for total and free IL-18, respectively). In both cohorts, a platelet 
      count </=20/nL on day +28 was associated with a significantly increased hazard of 
      NRM (hazard ratio 2.13 and 2.94, respectively). Our findings support the 
      hypothesis that elevated peritransplant IL-18 levels affect post-transplant HSPC 
      function and may provide a rationale to explore modulation of IL-18 for improving 
      alloSCT outcomes.
FAU - Radujkovic, Aleksandar
AU  - Radujkovic A
AUID- ORCID: 0000-0002-8543-5016
AD  - Department of Internal Medicine V, University Hospital Heidelberg, 69120 
      Heidelberg, Germany.
FAU - Kordelas, Lambros
AU  - Kordelas L
AUID- ORCID: 0000-0003-3116-473X
AD  - Department of Bone Marrow Transplantation, University Hospital Essen, University 
      of Duisburg-Essen, 45147 Essen, Germany.
FAU - Bogdanov, Rashit
AU  - Bogdanov R
AD  - Department of Bone Marrow Transplantation, University Hospital Essen, University 
      of Duisburg-Essen, 45147 Essen, Germany.
FAU - Muller-Tidow, Carsten
AU  - Muller-Tidow C
AD  - Department of Internal Medicine V, University Hospital Heidelberg, 69120 
      Heidelberg, Germany.
FAU - Beelen, Dietrich W
AU  - Beelen DW
AD  - Department of Bone Marrow Transplantation, University Hospital Essen, University 
      of Duisburg-Essen, 45147 Essen, Germany.
FAU - Dreger, Peter
AU  - Dreger P
AD  - Department of Internal Medicine V, University Hospital Heidelberg, 69120 
      Heidelberg, Germany.
FAU - Luft, Thomas
AU  - Luft T
AD  - Department of Internal Medicine V, University Hospital Heidelberg, 69120 
      Heidelberg, Germany.
LA  - eng
GR  - na/Helmholtz-Alliance on Immunotherapy of Cancer/
GR  - na/B.L.U.T. e.V. (Weingarten, Germany)/
GR  - GrantNo. 2008.068.1/Wilhelm-Sander-Stiftung/
PT  - Journal Article
DEP - 20200928
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC7601738
OTO - NOTNLM
OT  - allogeneic stem cell transplantation
OT  - hematopoietic recovery
OT  - interleukin-18
OT  - non-relapse mortality
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2020/10/02 06:00
MHDA- 2020/10/02 06:01
PMCR- 2020/09/28
CRDT- 2020/10/01 01:01
PHST- 2020/09/04 00:00 [received]
PHST- 2020/09/25 00:00 [revised]
PHST- 2020/09/26 00:00 [accepted]
PHST- 2020/10/01 01:01 [entrez]
PHST- 2020/10/02 06:00 [pubmed]
PHST- 2020/10/02 06:01 [medline]
PHST- 2020/09/28 00:00 [pmc-release]
AID - cancers12102789 [pii]
AID - cancers-12-02789 [pii]
AID - 10.3390/cancers12102789 [doi]
PST - epublish
SO  - Cancers (Basel). 2020 Sep 28;12(10):2789. doi: 10.3390/cancers12102789.