PMID- 32998989
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 43
IP  - 12
DP  - 2020 Dec
TI  - Lower Daily Carbohydrate Intake Is Associated With Improved Glycemic Control in 
      Adults With Type 1 Diabetes Using a Hybrid Closed-Loop System.
PG  - 3102-3105
LID - 10.2337/dc20-1560 [doi]
AB  - OBJECTIVE: To assess the association between daily carbohydrate (CHO) intake and 
      glycemic control in adult hybrid closed-loop (HCL) users with type 1 diabetes 
      (T1D). RESEARCH DESIGN AND METHODS: Mean individual daily CHO intake (MIDC) and 
      relative deviation from MIDC (</=80% low, 81-120% medium, >120% high CHO 
      consumption) were compared with parameters of glycemic control assessed by 
      continuous glucose monitoring. RESULTS: Records from 36 patients (26 male, 10 
      female; age 36.9 +/- 13.5 years; HbA(1c) 7.1 +/- 0.9% [54 +/- 10 mmol/mol]) provided 
      810 days of data (22.5 +/- 6.7 days per patient). Time in range (70-180 mg/dL) for 
      low, medium, and high CHO consumption was 77.4 +/- 15.4%, 75.2 +/- 16.7%, and 70.4 +/- 
      17.8%, respectively (P < 0.001). Time above range (>180 mg/dL) was 20.1 +/- 14.7%, 
      22.0 +/- 16.9%, and 27.2 +/- 18.4%, respectively (P < 0.001). There was no 
      between-group difference for time in hypoglycemia (<70 mg/dL; P = 0.50). 
      CONCLUSIONS: Daily CHO intake was inversely associated with glycemic control in 
      adults with T1D using an HCL system. Lower CHO intake may be a strategy to 
      optimize glucose control in HCL users.
CI  - (c) 2020 by the American Diabetes Association.
FAU - Lehmann, Vera
AU  - Lehmann V
AD  - Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, 
      Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
FAU - Zueger, Thomas
AU  - Zueger T
AD  - Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, 
      Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
AD  - Department of Management, Technology, and Economics, ETH Zurich, Zurich, 
      Switzerland.
FAU - Zeder, Anna
AU  - Zeder A
AD  - Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, 
      Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
FAU - Scott, Sam
AU  - Scott S
AUID- ORCID: 0000-0003-2342-9865
AD  - Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, 
      Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
AD  - Team Novo Nordisk Professional Cycling Team, Atlanta, GA.
FAU - Bally, Lia
AU  - Bally L
AUID- ORCID: 0000-0003-1993-7672
AD  - Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, 
      Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
FAU - Laimer, Markus
AU  - Laimer M
AUID- ORCID: 0000-0002-7622-0822
AD  - Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, 
      Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
FAU - Stettler, Christoph
AU  - Stettler C
AUID- ORCID: 0000-0003-1691-6059
AD  - Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, 
      Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland 
      christoph.stettler@insel.ch.
LA  - eng
SI  - figshare/10.2337/figshare.12962561
PT  - Journal Article
DEP - 20200930
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/drug effects/metabolism
MH  - Blood Glucose Self-Monitoring/instrumentation/methods
MH  - *Diabetes Mellitus, Type 1/blood/diet therapy/drug therapy
MH  - *Diet, Carbohydrate-Restricted
MH  - Eating/physiology
MH  - Female
MH  - Glycemic Control/*methods
MH  - Humans
MH  - Hypoglycemia/blood/chemically induced
MH  - Hypoglycemic Agents/administration & dosage
MH  - Insulin/*administration & dosage
MH  - *Insulin Infusion Systems
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2020/10/02 06:00
MHDA- 2021/05/29 06:00
CRDT- 2020/10/01 05:30
PHST- 2020/06/24 00:00 [received]
PHST- 2020/09/11 00:00 [accepted]
PHST- 2020/10/02 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
PHST- 2020/10/01 05:30 [entrez]
AID - dc20-1560 [pii]
AID - 10.2337/dc20-1560 [doi]
PST - ppublish
SO  - Diabetes Care. 2020 Dec;43(12):3102-3105. doi: 10.2337/dc20-1560. Epub 2020 Sep 
      30.