PMID- 32999681
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201002
IS  - 1663-2699 (Print)
IS  - 1663-2699 (Electronic)
IS  - 1663-2699 (Linking)
VI  - 11
IP  - 2
DP  - 2020 May-Aug
TI  - Optical Coherence Tomography Findings (SD-OCT and OCTA) in Early-Stage Type 3 
      Neovascularization.
PG  - 493-499
LID - 10.1159/000509139 [doi]
AB  - A 76-year-old male presented with a small hyperreflective density in the outer 
      nuclear layer with subtle retinal pigment epithelium (RPE) elevation and few 
      intraretinal cysts on spectral-domain optical coherence tomography (SD-OCT). 
      Optical coherence tomography angiography (OCTA) confirmed the presence of a 
      tuft-shaped intraretinal neovascular lesion. SD-OCT performed 2 months before 
      showed a smaller RPE elevation at the same location without intraretinal fluid. A 
      79-year-old male presented with a small hyperreflective density in the outer 
      retina surrounded by scant intraretinal fluid on SD-OCT and a bright vessel on 
      OCTA, suggesting early-stage type 3 neovascularization. SD-OCT performed 2 months 
      before showed a smaller hyperreflectivity at the same location, without 
      intraretinal fluid. An 84-year-old female presented with hyperreflective foci in 
      the outer retina overlying a serous pigment epithelium detachment (PED) with 
      focal RPE disruption on SD-OCT. SD-OCT performed 2 months before showed the same 
      hyperreflective lesion associated with a shallower PED. No neovascular lesions 
      were found on OCTA after six injections of bevacizumab. To conclude, careful 
      evaluation of SD-OCT allows for early detection of type 3 neovascularization at a 
      pre-exudative stage. OCTA may be useful in confirming the presence of 
      intraretinal neovascular lesion and monitoring response to anti-vascular 
      endothelial growth factor agents.
CI  - Copyright (c) 2020 by S. Karger AG, Basel.
FAU - Silva, Nisa
AU  - Silva N
AD  - Servico de Oftalmologia, Centro Hospitalar e Universitario do Porto, Porto, 
      Portugal.
FAU - Marta, Ana
AU  - Marta A
AD  - Servico de Oftalmologia, Centro Hospitalar e Universitario do Porto, Porto, 
      Portugal.
FAU - Baptista, Pedro
AU  - Baptista P
AD  - Servico de Oftalmologia, Centro Hospitalar e Universitario do Porto, Porto, 
      Portugal.
FAU - Furtado, Maria Joao
AU  - Furtado MJ
AD  - Servico de Oftalmologia, Centro Hospitalar e Universitario do Porto, Porto, 
      Portugal.
FAU - Lume, Miguel
AU  - Lume M
AD  - Servico de Oftalmologia, Centro Hospitalar e Universitario do Porto, Porto, 
      Portugal.
LA  - eng
PT  - Case Reports
DEP - 20200819
PL  - Switzerland
TA  - Case Rep Ophthalmol
JT  - Case reports in ophthalmology
JID - 101532006
PMC - PMC7506272
OTO - NOTNLM
OT  - Age-related macular degeneration
OT  - Early-stage type 3 macular neovascularization
OT  - Optical coherence tomography
COIS- The authors have no conflicts of interest to declare.
EDAT- 2020/10/02 06:00
MHDA- 2020/10/02 06:01
PMCR- 2020/08/19
CRDT- 2020/10/01 05:37
PHST- 2020/04/02 00:00 [received]
PHST- 2020/06/03 00:00 [accepted]
PHST- 2020/10/01 05:37 [entrez]
PHST- 2020/10/02 06:00 [pubmed]
PHST- 2020/10/02 06:01 [medline]
PHST- 2020/08/19 00:00 [pmc-release]
AID - cop-0011-0493 [pii]
AID - 10.1159/000509139 [doi]
PST - epublish
SO  - Case Rep Ophthalmol. 2020 Aug 19;11(2):493-499. doi: 10.1159/000509139. 
      eCollection 2020 May-Aug.