PMID- 33000166
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 150
IP  - Suppl 1
DP  - 2020 Oct 1
TI  - Metabolic Consequences of Supplemented Methionine in a Clinical Context.
PG  - 2538S-2547S
LID - 10.1093/jn/nxaa254 [doi]
AB  - The central position of methionine (Met) in protein metabolism indicates the 
      importance of this essential amino acid for growth and maintenance of lean body 
      mass. Therefore, Met might be a tempting candidate for supplementation. However, 
      because Met is also the precursor of homocysteine (Hcy), a deficient intake of B 
      vitamins or excessive intake of Met may result in hyperhomocysteinemia (HHcy), 
      which is a risk factor for cardiovascular disease. This review discusses the 
      evidence generated in preclinical and clinical studies on the importance and 
      potentially harmful effects of Met supplementation and elaborates on potential 
      clinical applications of supplemental Met with reference to clinical studies 
      performed over the past 20 y. Recently acquired knowledge about the NOAEL (no 
      observed adverse effect level) of 46.3 mg . kg-1 . d-1 and the LOAEL (lowest 
      observed adverse effect level) of 91 mg . kg-1 . d-1 of supplemented Met will 
      guide the design of future studies to further establish the role of Met as a 
      potential (safe) candidate for nutritional supplementation in clinical 
      applications.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      American Society for Nutrition.
FAU - Ligthart-Melis, Gerdien C
AU  - Ligthart-Melis GC
AD  - Center for Translational Research in Aging & Longevity, Department of Health & 
      Kinesiology, Texas A&M University, College Station, Texas, USA.
FAU - Engelen, Marielle P K J
AU  - Engelen MPKJ
AD  - Center for Translational Research in Aging & Longevity, Department of Health & 
      Kinesiology, Texas A&M University, College Station, Texas, USA.
FAU - Simbo, Sunday Y
AU  - Simbo SY
AD  - Center for Translational Research in Aging & Longevity, Department of Health & 
      Kinesiology, Texas A&M University, College Station, Texas, USA.
FAU - Ten Have, Gabrie A M
AU  - Ten Have GAM
AD  - Center for Translational Research in Aging & Longevity, Department of Health & 
      Kinesiology, Texas A&M University, College Station, Texas, USA.
FAU - Thaden, John J
AU  - Thaden JJ
AD  - Center for Translational Research in Aging & Longevity, Department of Health & 
      Kinesiology, Texas A&M University, College Station, Texas, USA.
FAU - Cynober, Luc
AU  - Cynober L
AD  - Department of Clinical Chemistry, Hopital Cochin, Hopitaux Universitaires Paris 
      Centre, Paris, France.
FAU - Deutz, Nicolaas E P
AU  - Deutz NEP
AD  - Center for Translational Research in Aging & Longevity, Department of Health & 
      Kinesiology, Texas A&M University, College Station, Texas, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Proteins)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 12001-76-2 (Vitamin B Complex)
RN  - AE28F7PNPL (Methionine)
SB  - IM
MH  - Animals
MH  - Body Fluid Compartments/*metabolism
MH  - Cardiovascular Diseases/*etiology/metabolism
MH  - *Dietary Supplements
MH  - Female
MH  - Homocysteine/*metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/*etiology/metabolism
MH  - Male
MH  - *Methionine/adverse effects/metabolism/pharmacology/therapeutic use
MH  - Proteins/metabolism
MH  - Vitamin B Complex/blood
MH  - Vitamin B Deficiency/blood/*complications
OTO - NOTNLM
OT  - LOAEL
OT  - NOAEL
OT  - cardiovascular disease
OT  - homocysteine
OT  - hyperhomocysteinemia
OT  - lean body mass
OT  - methionine
EDAT- 2020/10/02 06:00
MHDA- 2021/01/26 06:00
CRDT- 2020/10/01 05:39
PHST- 2019/12/10 00:00 [received]
PHST- 2020/04/01 00:00 [revised]
PHST- 2020/07/31 00:00 [accepted]
PHST- 2020/10/01 05:39 [entrez]
PHST- 2020/10/02 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
AID - S0022-3166(22)02436-1 [pii]
AID - 10.1093/jn/nxaa254 [doi]
PST - ppublish
SO  - J Nutr. 2020 Oct 1;150(Suppl 1):2538S-2547S. doi: 10.1093/jn/nxaa254.