PMID- 33000620
OWN - NLM
STAT- MEDLINE
DCOM- 20210824
LR  - 20210824
IS  - 1827-1634 (Electronic)
IS  - 0391-1977 (Linking)
VI  - 45
IP  - 3
DP  - 2020 Sep
TI  - The possible role of endocrine dysfunction of adipose tissue in gestational 
      diabetes mellitus.
PG  - 228-242
LID - 10.23736/S0391-1977.20.03192-2 [doi]
AB  - Gestational diabetes mellitus (GDM) is diabetes that is first diagnosed in the 
      second or third trimester of pregnancy in patients who did not have a history of 
      diabetes before pregnancy. Consequences of GDM include increased risk of 
      macrosomia and birth complications in the infant and an increased risk of 
      maternal type 2 diabetes mellitus (T2DM) after pregnancy. There is also a 
      longer-term risk of obesity, T2DM, and cardiovascular diseases in the child. GDM 
      is the result of impaired glucose tolerance due to pancreatic beta-cell dysfunction 
      on a background of insulin resistance that physiologically increases during 
      pregnancy. The strongest clinical predictors of GDM are overweight and obesity. 
      The fact that women with GDM are more likely to be overweight or obese suggests 
      that adipose tissue dysfunction may be involved in the pathogenesis of GDM, 
      similarly to T2DM. Adipose tissue is not only involved in energy storage but also 
      functions as an active endocrine organ secreting adipokines (specific hormones 
      and cytokines) with the ability to alter insulin sensitivity. Recent evidence 
      points to a crucial role of numerous adipokines produced by fat in the 
      development of GDM. The following text summarizes the current knowledge about a 
      possible role of selected adipokines in the development of GDM.
FAU - Simjak, Patrik
AU  - Simjak P
AD  - Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles 
      University and General University Hospital, Prague, Czech Republic.
FAU - Anderlova, Katerina
AU  - Anderlova K
AD  - Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles 
      University and General University Hospital, Prague, Czech Republic.
AD  - Third Department of Medicine, First Faculty of Medicine, Charles University and 
      General University Hospital, Prague, Czech Republic.
FAU - Cinkajzlova, Anna
AU  - Cinkajzlova A
AD  - Center for Experimental Medicine, Institute for Clinical and Experimental 
      Medicine, Prague, Czech Republic.
FAU - Parizek, Antonin
AU  - Parizek A
AD  - Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles 
      University and General University Hospital, Prague, Czech Republic.
FAU - Krsek, Michal
AU  - Krsek M
AD  - Third Department of Medicine, First Faculty of Medicine, Charles University and 
      General University Hospital, Prague, Czech Republic.
FAU - Haluzik, Martin
AU  - Haluzik M
AD  - Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech 
      Republic - halm@ikem.cz.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Italy
TA  - Minerva Endocrinol
JT  - Minerva endocrinologica
JID - 8406505
SB  - IM
MH  - Adipose Tissue/*physiopathology
MH  - Adult
MH  - Diabetes, Gestational/etiology/*physiopathology
MH  - Endocrine System Diseases/complications/*physiopathology
MH  - Female
MH  - Humans
MH  - Pregnancy
EDAT- 2020/10/02 06:00
MHDA- 2021/08/25 06:00
CRDT- 2020/10/01 08:16
PHST- 2020/10/01 08:16 [entrez]
PHST- 2020/10/02 06:00 [pubmed]
PHST- 2021/08/25 06:00 [medline]
AID - S0391-1977.20.03192-2 [pii]
AID - 10.23736/S0391-1977.20.03192-2 [doi]
PST - ppublish
SO  - Minerva Endocrinol. 2020 Sep;45(3):228-242. doi: 10.23736/S0391-1977.20.03192-2.