PMID- 33002783
OWN - NLM
STAT- MEDLINE
DCOM- 20210729
LR  - 20210729
IS  - 1873-3727 (Electronic)
IS  - 0001-8686 (Linking)
VI  - 285
DP  - 2020 Nov
TI  - Polymer colloids as drug delivery systems for the treatment of arthritis.
PG  - 102273
LID - S0001-8686(20)30542-X [pii]
LID - 10.1016/j.cis.2020.102273 [doi]
AB  - The most common types of arthritis are osteoarthritis (OA) and rheumatoid 
      arthritis (RA) which are themain causes of disability and pain among older 
      people. Current treatment of arthritis mainly consists of oral and 
      intra-articular medications. Despite the efficacy of the intraarticular 
      injections over the oral treatment, it is still limited by the rapid clearance of 
      the injected drug. Therefore, a rational design of drug delivery systems (DDSs) 
      able to delivery drugs in controlled manner and for required period of time to 
      the arthritis joint is a key in developing safe and effective formulations for OA 
      and RA. In this paper various colloidal systems like nanoparticles, liposomes, 
      cationic carriers, hydrogels, and emulsion-based carriers were presented and 
      discussed in light of their use and efficacy as delivery systems to transport 
      therapeutics for arthritis treatment. Factors influencing the delivery efficacy 
      such as size, charge, structure, drug uptake, retention and its release profile 
      alongside with cytocompatibility and safety were addressed. Moreover, the 
      advantages and disadvantages of the different colloidal systems were emphasised.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Saeedi, Tahani
AU  - Saeedi T
AD  - School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, UK.
FAU - Alotaibi, Hadil Faris
AU  - Alotaibi HF
AD  - Department of Pharmaceutical Sciences, Pharmacy college, Princess Nourah bint 
      Abdulrahman University, Saudi Arabia.
FAU - Prokopovich, Polina
AU  - Prokopovich P
AD  - School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, UK. 
      Electronic address: prokopovichp@cf.ac.uk.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200918
PL  - Netherlands
TA  - Adv Colloid Interface Sci
JT  - Advances in colloid and interface science
JID - 8706645
RN  - 0 (Colloids)
RN  - 0 (Drug Carriers)
RN  - 0 (Polymers)
SB  - IM
MH  - Animals
MH  - Arthritis/*drug therapy
MH  - Colloids
MH  - Drug Carriers/*chemistry
MH  - Humans
MH  - Polymers/*chemistry
OTO - NOTNLM
OT  - Cationic carriers
OT  - Drug delivery system
OT  - Emulsion
OT  - Hydrogels
OT  - Liposomes
OT  - Nanoparticles
OT  - Osteoarthritis
OT  - PBAEs
OT  - Rheumatoid arthritis
EDAT- 2020/10/02 06:00
MHDA- 2021/07/30 06:00
CRDT- 2020/10/01 20:17
PHST- 2020/06/21 00:00 [received]
PHST- 2020/09/07 00:00 [revised]
PHST- 2020/09/15 00:00 [accepted]
PHST- 2020/10/02 06:00 [pubmed]
PHST- 2021/07/30 06:00 [medline]
PHST- 2020/10/01 20:17 [entrez]
AID - S0001-8686(20)30542-X [pii]
AID - 10.1016/j.cis.2020.102273 [doi]
PST - ppublish
SO  - Adv Colloid Interface Sci. 2020 Nov;285:102273. doi: 10.1016/j.cis.2020.102273. 
      Epub 2020 Sep 18.