PMID- 33005141
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 14
DP  - 2020
TI  - Altered Static and Dynamic Spontaneous Neural Activity in Drug-Naive and 
      Drug-Receiving Benign Childhood Epilepsy With Centrotemporal Spikes.
PG  - 361
LID - 10.3389/fnhum.2020.00361 [doi]
LID - 361
AB  - The present study aims to investigate intrinsic abnormalities of brain and the 
      effect of antiepileptic treatment on brain activity in Benign childhood epilepsy 
      with centrotemporal spikes (BECTS). Twenty-six drug-naive patients (DNP) and 22 
      drug-receiving patients (DRP) with BECTS were collected in this study. Static 
      amplitude of low frequency fluctuation (sALFF) and dynamic ALFF (dALFF) were 
      applied to resting-state fMRI data. Functional connectivity (FC) analysis was 
      further performed for affected regions identified by static and dynamic analysis. 
      One-way analysis of variance and post hoc statistical analyses were performed for 
      between-group differences. Abnormal sALFF and dALFF values were correlated with 
      clinical features of patients. Compared with healthy controls (HC), DNP group 
      demonstrated alterations of sALFF and/or dALFF in medial prefrontal cortex 
      (MPFC), supplementary motor areas (SMA), cerebellum, hippocampus, pallidum and 
      cingulate cortex, in which the values were close to normal in DRP. Notably, sALFF 
      and dALFF showed specific sensitivity in detecting abnormalities in basal ganglia 
      and cerebellum. Additionally, DRP showed additional changes in precuneus, 
      inferior temporal gyrus, superior frontal gyrus and occipital visual cortex. 
      Compared with HC, the DNP showed increased FC in default network and 
      motion-related networks, and the DRP showed decreased FC in default network. The 
      MPFC, hippocampus, SMA, basal ganglia and cerebellum are indicated to be 
      intrinsically affected regions and effective therapeutic targets. And the FC 
      profiles of default and motion-related networks might be potential core 
      indicators for clinical treatment. This study revealed potential neuromodulatory 
      targets and helped understand pathomechanism of BECTS. Static and dynamic 
      analyses should be combined to investigate neuropsychiatric disorders.
CI  - Copyright (c) 2020 Jiang, Luo, Huang, Li, Chen, Li, Pei, Wang, Wang and Yao.
FAU - Jiang, Sisi
AU  - Jiang S
AD  - The Clinical Hospital of Chengdu Brain Science Institute, Key Laboratory for 
      NeuroInformation of Ministry of Education, Center for Information in Medicine, 
      High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, 
      School of Life Sciences and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Luo, Cheng
AU  - Luo C
AD  - The Clinical Hospital of Chengdu Brain Science Institute, Key Laboratory for 
      NeuroInformation of Ministry of Education, Center for Information in Medicine, 
      High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, 
      School of Life Sciences and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
AD  - Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu, 
      China.
FAU - Huang, Yang
AU  - Huang Y
AD  - The Clinical Hospital of Chengdu Brain Science Institute, Key Laboratory for 
      NeuroInformation of Ministry of Education, Center for Information in Medicine, 
      High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, 
      School of Life Sciences and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Li, Zhiliang
AU  - Li Z
AD  - The Clinical Hospital of Chengdu Brain Science Institute, Key Laboratory for 
      NeuroInformation of Ministry of Education, Center for Information in Medicine, 
      High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, 
      School of Life Sciences and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Chen, Yan
AU  - Chen Y
AD  - The Clinical Hospital of Chengdu Brain Science Institute, Key Laboratory for 
      NeuroInformation of Ministry of Education, Center for Information in Medicine, 
      High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, 
      School of Life Sciences and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Li, Xiangkui
AU  - Li X
AD  - The Clinical Hospital of Chengdu Brain Science Institute, Key Laboratory for 
      NeuroInformation of Ministry of Education, Center for Information in Medicine, 
      High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, 
      School of Life Sciences and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Pei, Haonan
AU  - Pei H
AD  - The Clinical Hospital of Chengdu Brain Science Institute, Key Laboratory for 
      NeuroInformation of Ministry of Education, Center for Information in Medicine, 
      High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, 
      School of Life Sciences and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Wang, Pingfu
AU  - Wang P
AD  - The Clinical Hospital of Chengdu Brain Science Institute, Key Laboratory for 
      NeuroInformation of Ministry of Education, Center for Information in Medicine, 
      High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, 
      School of Life Sciences and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
FAU - Wang, Xiaoming
AU  - Wang X
AD  - Department of Neurology, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong, China.
FAU - Yao, Dezhong
AU  - Yao D
AD  - The Clinical Hospital of Chengdu Brain Science Institute, Key Laboratory for 
      NeuroInformation of Ministry of Education, Center for Information in Medicine, 
      High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, 
      School of Life Sciences and Technology, University of Electronic Science and 
      Technology of China, Chengdu, China.
AD  - Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20200828
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC7485420
OTO - NOTNLM
OT  - drug treatment
OT  - dynamic
OT  - epilepsy
OT  - spontaneous neural activity
OT  - static
EDAT- 2020/10/03 06:00
MHDA- 2020/10/03 06:01
PMCR- 2020/01/01
CRDT- 2020/10/02 05:43
PHST- 2020/06/22 00:00 [received]
PHST- 2020/08/07 00:00 [accepted]
PHST- 2020/10/02 05:43 [entrez]
PHST- 2020/10/03 06:00 [pubmed]
PHST- 2020/10/03 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2020.00361 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2020 Aug 28;14:361. doi: 10.3389/fnhum.2020.00361. 
      eCollection 2020.