PMID- 33005645
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240214
IS  - 2297-1769 (Print)
IS  - 2297-1769 (Electronic)
IS  - 2297-1769 (Linking)
VI  - 7
DP  - 2020
TI  - Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in 
      Veterinary Medicine.
PG  - 580
LID - 10.3389/fvets.2020.00580 [doi]
LID - 580
AB  - The veterinary pharmacopeia available to treat pain and inflammation is limited 
      in number, target of action and efficacy. Inhibitors of soluble epoxide hydrolase 
      (sEH) are a new class of anti-inflammatory, pro-resolving and analgesic drugs 
      being tested in humans that have demonstrated efficacy in laboratory animals. 
      They block the hydrolysis, and thus, increase endogenous concentrations of 
      analgesic and anti-inflammatory signaling molecules called epoxy-fatty acids. 
      Here, we screened a library of 2,300 inhibitors of the sEH human against 
      partially purified feline, canine and equine hepatic sEH to identify inhibitors 
      that are broadly potent among species. Six very potent sEH inhibitors (IC(50) < 1 
      nM for each enzyme tested) were identified. Their microsomal stability was then 
      measured in hepatic extracts from cat, dog and horse, as well as their solubility 
      in solvents suitable for the formulation of drugs. The 
      trans-4-4-[3-(4-trifluoromethoxy-phenyl)-ureido]-cyclohexyloxy-benzoic acid 
      (t-TUCB, 1,728) appears to be the best compromise between stability and potency 
      across species. Thus, it was selected for further testing in veterinary clinical 
      trials of pain and inflammation in animals.
CI  - Copyright (c) 2020 Shihadih, Harris, Kodani, Hwang, Lee, Mavangira, Hamamoto, 
      Guedes, Hammock and Morisseau.
FAU - Shihadih, Diyala S
AU  - Shihadih DS
AD  - Department of Entomology and Nematology, U.C. Davis Comprehensive Cancer Center, 
      University of California, Davis, Davis, CA, United States.
FAU - Harris, Todd R
AU  - Harris TR
AD  - Department of Entomology and Nematology, U.C. Davis Comprehensive Cancer Center, 
      University of California, Davis, Davis, CA, United States.
FAU - Kodani, Sean D
AU  - Kodani SD
AD  - Department of Entomology and Nematology, U.C. Davis Comprehensive Cancer Center, 
      University of California, Davis, Davis, CA, United States.
FAU - Hwang, Sung-Hee
AU  - Hwang SH
AD  - Department of Entomology and Nematology, U.C. Davis Comprehensive Cancer Center, 
      University of California, Davis, Davis, CA, United States.
FAU - Lee, Kin Sing Stephen
AU  - Lee KSS
AD  - Department of Entomology and Nematology, U.C. Davis Comprehensive Cancer Center, 
      University of California, Davis, Davis, CA, United States.
AD  - Department of Pharmacology and Toxicology and Department of Chemistry, Michigan 
      State University, East Lansing, MI, United States.
FAU - Mavangira, Vengai
AU  - Mavangira V
AD  - Department of Large Animal Clinical Sciences, College of Veterinary Medicine, 
      Michigan State University, East Lansing, MI, United States.
FAU - Hamamoto, Briana
AU  - Hamamoto B
AD  - Department of Surgical and Radiological Sciences, School of Veterinary Medicine, 
      University of California, Davis, Davis, CA, United States.
FAU - Guedes, Alonso
AU  - Guedes A
AD  - Department of Surgical and Radiological Sciences, School of Veterinary Medicine, 
      University of California, Davis, Davis, CA, United States.
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, 
      University of Minnesota, St Paul, MN, United States.
FAU - Hammock, Bruce D
AU  - Hammock BD
AD  - Department of Entomology and Nematology, U.C. Davis Comprehensive Cancer Center, 
      University of California, Davis, Davis, CA, United States.
FAU - Morisseau, Christophe
AU  - Morisseau C
AD  - Department of Entomology and Nematology, U.C. Davis Comprehensive Cancer Center, 
      University of California, Davis, Davis, CA, United States.
LA  - eng
GR  - P42 ES004699/ES/NIEHS NIH HHS/United States
GR  - R00 ES024806/ES/NIEHS NIH HHS/United States
GR  - R35 ES030443/ES/NIEHS NIH HHS/United States
GR  - T32 GM099608/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20200826
PL  - Switzerland
TA  - Front Vet Sci
JT  - Frontiers in veterinary science
JID - 101666658
PMC - PMC7479175
OTO - NOTNLM
OT  - cat
OT  - dog
OT  - epoxyeicosatrienoic acids
OT  - horse
OT  - pain
EDAT- 2020/10/03 06:00
MHDA- 2020/10/03 06:01
PMCR- 2020/01/01
CRDT- 2020/10/02 05:46
PHST- 2020/05/28 00:00 [received]
PHST- 2020/07/20 00:00 [accepted]
PHST- 2020/10/02 05:46 [entrez]
PHST- 2020/10/03 06:00 [pubmed]
PHST- 2020/10/03 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fvets.2020.00580 [doi]
PST - epublish
SO  - Front Vet Sci. 2020 Aug 26;7:580. doi: 10.3389/fvets.2020.00580. eCollection 
      2020.