PMID- 33007401
OWN - NLM
STAT- MEDLINE
DCOM- 20210907
LR  - 20210907
IS  - 2666-9919 (Electronic)
IS  - 2666-9919 (Linking)
VI  - 51
IP  - 1
DP  - 2021 Feb
TI  - Increased risk of IRIS-associated tuberculosis in HIV-infected patients receiving 
      Integrase Inhibitors.
PG  - 90-93
LID - S0399-077X(20)30703-4 [pii]
LID - 10.1016/j.medmal.2020.09.005 [doi]
AB  - BACKGROUND: Tuberculosis is associated with a risk of immune reconstitution 
      inflammatory syndrome (IRIS) after ART initiation. METHODS: Data from all 
      patients with newly diagnosed tuberculosis disease and uncontrolled HIV infection 
      from 1997 to 2017 in a French center were retrospectively collected. We evaluated 
      the incidence of tuberculosis-IRIS in patients initiating ART with or without 
      integrase inhibitors (INSTI) RESULTS: Fifty-five patients were included: 21 
      receiving an INSTI regimen and 34 a non-INSTI regimen. Except with regard to ART 
      regimen, the two groups were comparable (median CD4 of 85/mm(3)). The overall 
      percentage of IRIS was 34% (19/55), with 52% IRIS in INSTI regimen and 23% in 
      non-INSTI regimen respectively (P=0.04). In a multivariate logistic model, we 
      observed an increased risk of IRIS in the INSTI regimen compared to the 
      non-INSTI, with an OR at 3.33 [95% CI, 1.01-11.1] (P=0.05) CONCLUSIONS: ART 
      containing integrase inhibitors could be associated with increased incidence of 
      TB-associated IRIS.
CI  - Copyright (c) 2020 Elsevier Masson SAS. All rights reserved.
FAU - Gaillet, A
AU  - Gaillet A
AD  - Assistance Publique-Hopitaux de Paris, Sorbonne Universite, Department of 
      Infectious Diseases, Pitie-Salpetriere Hospital, 47-83 Boulevard de l'Hopital, 
      Paris 75013, France. Electronic address: gaillet.antoine75@gmail.com.
FAU - Calin, R
AU  - Calin R
AD  - Assistance Publique-Hopitaux de Paris, Sorbonne Universite, Department of 
      Infectious Diseases, Pitie-Salpetriere Hospital, 47-83 Boulevard de l'Hopital, 
      Paris 75013, France; Inserm UMR-S 1136, Pierre Louis Institute of Epidemiology 
      and Public Health, Sorbonne Universite, Paris, France.
FAU - Flandre, P
AU  - Flandre P
AD  - Inserm UMR-S 1136, Pierre Louis Institute of Epidemiology and Public Health, 
      Sorbonne Universite, Paris, France.
FAU - Tubiana, R
AU  - Tubiana R
AD  - Assistance Publique-Hopitaux de Paris, Sorbonne Universite, Department of 
      Infectious Diseases, Pitie-Salpetriere Hospital, 47-83 Boulevard de l'Hopital, 
      Paris 75013, France; Inserm UMR-S 1136, Pierre Louis Institute of Epidemiology 
      and Public Health, Sorbonne Universite, Paris, France.
FAU - Valantin, M-A
AU  - Valantin MA
AD  - Assistance Publique-Hopitaux de Paris, Sorbonne Universite, Department of 
      Infectious Diseases, Pitie-Salpetriere Hospital, 47-83 Boulevard de l'Hopital, 
      Paris 75013, France; Inserm UMR-S 1136, Pierre Louis Institute of Epidemiology 
      and Public Health, Sorbonne Universite, Paris, France.
FAU - Caumes, E
AU  - Caumes E
AD  - Assistance Publique-Hopitaux de Paris, Sorbonne Universite, Department of 
      Infectious Diseases, Pitie-Salpetriere Hospital, 47-83 Boulevard de l'Hopital, 
      Paris 75013, France; Inserm UMR-S 1136, Pierre Louis Institute of Epidemiology 
      and Public Health, Sorbonne Universite, Paris, France.
FAU - Katlama, C
AU  - Katlama C
AD  - Assistance Publique-Hopitaux de Paris, Sorbonne Universite, Department of 
      Infectious Diseases, Pitie-Salpetriere Hospital, 47-83 Boulevard de l'Hopital, 
      Paris 75013, France; Inserm UMR-S 1136, Pierre Louis Institute of Epidemiology 
      and Public Health, Sorbonne Universite, Paris, France.
FAU - Pourcher, V
AU  - Pourcher V
AD  - Assistance Publique-Hopitaux de Paris, Sorbonne Universite, Department of 
      Infectious Diseases, Pitie-Salpetriere Hospital, 47-83 Boulevard de l'Hopital, 
      Paris 75013, France; Inserm UMR-S 1136, Pierre Louis Institute of Epidemiology 
      and Public Health, Sorbonne Universite, Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20200929
PL  - France
TA  - Infect Dis Now
JT  - Infectious diseases now
JID - 101775152
RN  - 0 (Integrase Inhibitors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antiretroviral Therapy, Highly Active/adverse effects
MH  - Female
MH  - HIV Infections/*drug therapy/epidemiology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*epidemiology
MH  - Incidence
MH  - Integrase Inhibitors/*adverse effects/therapeutic use
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Retrospective Studies
MH  - Tuberculosis/*epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - HIV
OT  - INSTI
OT  - IRIS-associated tuberculosis
OT  - Integrase inhibitors
EDAT- 2020/10/03 06:00
MHDA- 2021/09/08 06:00
CRDT- 2020/10/02 20:10
PHST- 2020/02/28 00:00 [received]
PHST- 2020/09/21 00:00 [accepted]
PHST- 2020/10/03 06:00 [pubmed]
PHST- 2021/09/08 06:00 [medline]
PHST- 2020/10/02 20:10 [entrez]
AID - S0399-077X(20)30703-4 [pii]
AID - 10.1016/j.medmal.2020.09.005 [doi]
PST - ppublish
SO  - Infect Dis Now. 2021 Feb;51(1):90-93. doi: 10.1016/j.medmal.2020.09.005. Epub 
      2020 Sep 29.