PMID- 33008423
OWN - NLM
STAT- MEDLINE
DCOM- 20210104
LR  - 20221207
IS  - 1477-7525 (Electronic)
IS  - 1477-7525 (Linking)
VI  - 18
IP  - 1
DP  - 2020 Oct 2
TI  - Responsiveness and minimal clinically important difference of the EQ-5D-5L in 
      cervical intraepithelial neoplasia: a longitudinal study.
PG  - 324
LID - 10.1186/s12955-020-01578-8 [doi]
LID - 324
AB  - BACKGROUND: With the widespread clinical application of the five-level version of 
      the EuroQol five-dimensional questionnaire (EQ-5D-5L), whether the questionnaire 
      scores are responsive to changes in patients' health and how much changes in 
      questionnaire scores represent patients' real health changes require 
      consideration. Consequently, we assessed responsiveness and estimated the minimal 
      clinically important difference (MCID) of the EQ-5D-5L in surgically treated 
      patients with cervical intraepithelial neoplasia (CIN) to determine the 
      relationship between MCID and minimal detectable change (MDC). METHODS: We 
      conducted a longitudinal, observational study. Participants were patients with 
      CIN from the gynecology inpatient department of a grade-A tertiary hospital in 
      Shihezi, Xinjiang, China. Participants completed the EQ-5D-5L and the Global 
      Rating of Change Questionnaire (GRCQ) at baseline and one month post-surgery. The 
      Wilcoxon signed-rank test was used to compare EQ-5D-5L scores pre- and 
      post-treatment. We calculated the effect size (ES) and the standardized response 
      mean (SRM) to quantitatively assess responsiveness. Distribution-based, 
      anchor-based, and instrument-defined methods were used to estimate MCID. MCID to 
      MDC ratios at individual- and group-levels were also calculated. RESULTS: Fifty 
      patients with CIN completed the follow-up investigation (mean age 
      44.76 +/- 8.72 years; mean follow-up time 32.28 +/- 1.43 days). The index value and 
      EQ visual analogue scale (EQ VAS) of the EQ-5D-5L improved by 0.025 and 6.92 (all 
      p < 0.05) at follow-up as compared to baseline respectively. The ES and the SRM 
      of the index value were 0.47 and 0.42 respectively, indicating small 
      responsiveness; while the ES and the SRM of EQ VAS were 0.50 and 0.49 
      respectively, indicating small to moderate responsiveness. The average (range) of 
      MCIDs for index value and EQ VAS were 0.039 (0.023-0.064) and 5.35 (3.12-6.99) 
      respectively. These values can only be used to determine whether patients have 
      experienced clinically meaningful health improvements at the group level. 
      CONCLUSIONS: The EQ-5D-5L has only small to moderate responsiveness in 
      post-surgical patients with CIN, and the MCIDs developed in this study can be 
      used for group-level health assessment. However, further study is needed 
      concerning health changes at the individual level.
FAU - Hu, Xin
AU  - Hu X
AD  - Department of Public Health, Shihezi University School of Medicine, Shihezi, 
      Xinjiang, China.
FAU - Jing, Mingxia
AU  - Jing M
AUID- ORCID: 0000-0001-7928-1260
AD  - Department of Public Health, Shihezi University School of Medicine, Shihezi, 
      Xinjiang, China. jingmingxia163@163.com.
FAU - Zhang, Mei
AU  - Zhang M
AD  - Department of Public Health, Shihezi University School of Medicine, Shihezi, 
      Xinjiang, China.
FAU - Yang, Ping
AU  - Yang P
AD  - Department of Obstetrics and Gynaecology, The First Affiliated Hospital of 
      Shihezi University School of Medicine, Shihezi, Xinjiang, China.
FAU - Yan, Xiaolong
AU  - Yan X
AD  - Department of Public Health, Shihezi University School of Medicine, Shihezi, 
      Xinjiang, China.
LA  - eng
GR  - 2013BB015/The Xinjiang Production and Construction Corps Special Fund/
PT  - Journal Article
PT  - Observational Study
DEP - 20201002
PL  - England
TA  - Health Qual Life Outcomes
JT  - Health and quality of life outcomes
JID - 101153626
SB  - IM
MH  - Adult
MH  - China
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Minimal Clinically Important Difference
MH  - Postoperative Period
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Surveys and Questionnaires/*standards
MH  - Uterine Cervical Neoplasms/*psychology/surgery
MH  - Visual Analog Scale
MH  - Uterine Cervical Dysplasia/*psychology/surgery
PMC - PMC7531135
OTO - NOTNLM
OT  - CIN
OT  - EQ-5D-5L
OT  - MCID
OT  - MDC
OT  - Responsiveness
COIS- The authors declare that they have no competing interests.
EDAT- 2020/10/04 06:00
MHDA- 2021/01/05 06:00
PMCR- 2020/10/02
CRDT- 2020/10/03 05:21
PHST- 2020/02/29 00:00 [received]
PHST- 2020/09/24 00:00 [accepted]
PHST- 2020/10/03 05:21 [entrez]
PHST- 2020/10/04 06:00 [pubmed]
PHST- 2021/01/05 06:00 [medline]
PHST- 2020/10/02 00:00 [pmc-release]
AID - 10.1186/s12955-020-01578-8 [pii]
AID - 1578 [pii]
AID - 10.1186/s12955-020-01578-8 [doi]
PST - epublish
SO  - Health Qual Life Outcomes. 2020 Oct 2;18(1):324. doi: 10.1186/s12955-020-01578-8.