PMID- 33008471
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20210618
IS  - 1757-6512 (Electronic)
IS  - 1757-6512 (Linking)
VI  - 11
IP  - 1
DP  - 2020 Oct 2
TI  - Stem cell therapies for periodontal tissue regeneration: a network meta-analysis 
      of preclinical studies.
PG  - 427
LID - 10.1186/s13287-020-01938-7 [doi]
LID - 427
AB  - BACKGROUND: Periodontal tissue regeneration (PTR) is the ultimate goal of 
      periodontal therapy. Currently, stem cell therapy is considered a promising 
      strategy for achieving PTR. However, there is still no conclusive comparison that 
      distinguishes clear hierarchies among different kinds of stem cells. METHODS: A 
      systematic review and network meta-analysis (NMA) was performed using MEDLINE 
      (via PubMed), EMBASE, and Web of Science up to February 2020. Preclinical studies 
      assessing five types of stem cells for PTR were included; the five types of stem 
      cells included periodontal ligament-derived stem cells (PDLSCs), bone 
      marrow-derived stem cells (BMSCs), adipose tissue-derived stem cells (ADSCs), 
      dental pulp-derived stem cells (DPSCs), and gingival-derived stem cells (GMSCs). 
      The primary outcomes were three histological indicators with continuous 
      variables: newly formed alveolar bone (NB), newly formed cementum (NC), and newly 
      formed periodontal ligament (NPDL). We performed pairwise meta-analyses using a 
      random-effects model and then performed a random-effects NMA using a multivariate 
      meta-analysis model. RESULTS: Sixty preclinical studies assessing five different 
      stem cell-based therapies were identified. The NMA showed that in terms of NB, 
      PDLSCs (standardized mean difference 1.87, 95% credible interval 1.24 to 2.51), 
      BMSCs (1.88, 1.17 to 2.59), and DPSCs (1.69, 0.64 to 2.75) were statistically 
      more efficacious than cell carriers (CCs). In addition, PDLSCs were superior to 
      GMSCs (1.49, 0.04 to 2.94). For NC, PDLSCs (2.18, 1.48 to 2.87), BMSCs (2.11, 
      1.28 to 2.94), and ADSCs (1.55, 0.18 to 2.91) were superior to CCs. For NPDL, 
      PDLSCs (1.69, 0.92 to 2.47) and BMSCs (1.41, 0.56 to 2.26) were more efficacious 
      than CCs, and PDLSCs (1.26, 0.11 to 2.42) were superior to GMSCs. The results of 
      treatment hierarchies also demonstrated that the two highest-ranked interventions 
      were PDLSCs and BMSCs. CONCLUSION: PDLSCs and BMSCs were the most effective and 
      well-documented stem cells for PTR among the five kinds of stem cells evaluated 
      in this study, and there was no statistical significance between them. To 
      translate the stem cell therapies for PTR successfully in the clinic, future 
      studies should utilize robust experimental designs and reports.
FAU - Li, Qiang
AU  - Li Q
AD  - Department of Oral Implantology, Nanjing Stomatological Hospital, Medical School 
      of Nanjing University, Nanjing, China.
AD  - Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing 
      University, Nanjing, China.
FAU - Yang, Guangwen
AU  - Yang G
AD  - Department of Oral Implantology, Nanjing Stomatological Hospital, Medical School 
      of Nanjing University, Nanjing, China.
AD  - Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing 
      University, Nanjing, China.
FAU - Li, Jialing
AU  - Li J
AD  - Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing 
      University, Nanjing, China.
AD  - Department of Orthodontics, Nanjing Stomatological Hospital, Medical School of 
      Nanjing University, Nanjing, China.
FAU - Ding, Meng
AU  - Ding M
AD  - Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing 
      University, Nanjing, China.
FAU - Zhou, Na
AU  - Zhou N
AD  - Department of Oral Implantology, Nanjing Stomatological Hospital, Medical School 
      of Nanjing University, Nanjing, China.
FAU - Dong, Heng
AU  - Dong H
AUID- ORCID: 0000-0002-2537-7950
AD  - Department of Oral Implantology, Nanjing Stomatological Hospital, Medical School 
      of Nanjing University, Nanjing, China. dongheng90@smail.nju.edu.cn.
AD  - Central Laboratory, Nanjing Stomatological Hospital, Medical School of Nanjing 
      University, Nanjing, China. dongheng90@smail.nju.edu.cn.
FAU - Mou, Yongbin
AU  - Mou Y
AD  - Department of Oral Implantology, Nanjing Stomatological Hospital, Medical School 
      of Nanjing University, Nanjing, China. yongbinmou@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20201002
PL  - England
TA  - Stem Cell Res Ther
JT  - Stem cell research & therapy
JID - 101527581
SB  - IM
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Network Meta-Analysis
MH  - *Periodontal Ligament
MH  - *Stem Cells
PMC - PMC7531120
OTO - NOTNLM
OT  - Network meta-analysis
OT  - Periodontal defects
OT  - Periodontal tissue regeneration
OT  - Periodontitis
OT  - Stem cell therapy
OT  - Tissue engineering
COIS- The authors declare that they have no competing interests.
EDAT- 2020/10/04 06:00
MHDA- 2021/06/22 06:00
PMCR- 2020/10/02
CRDT- 2020/10/03 05:21
PHST- 2020/06/17 00:00 [received]
PHST- 2020/09/16 00:00 [accepted]
PHST- 2020/10/03 05:21 [entrez]
PHST- 2020/10/04 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/10/02 00:00 [pmc-release]
AID - 10.1186/s13287-020-01938-7 [pii]
AID - 1938 [pii]
AID - 10.1186/s13287-020-01938-7 [doi]
PST - epublish
SO  - Stem Cell Res Ther. 2020 Oct 2;11(1):427. doi: 10.1186/s13287-020-01938-7.