PMID- 33010349
OWN - NLM
STAT- MEDLINE
DCOM- 20211026
LR  - 20211026
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 165
DP  - 2020 Dec
TI  - Mesenchymal stem cells-derived mitochondria transplantation mitigates I/R-induced 
      injury, abolishes I/R-induced apoptosis, and restores motor function in acute 
      ischemia stroke rat model.
PG  - 70-80
LID - S0361-9230(20)30640-7 [pii]
LID - 10.1016/j.brainresbull.2020.09.018 [doi]
AB  - Acute ischemia stroke (AIS) is one of the leading causes of mortality and 
      disability worldwide, and its neurological impacts are devastating and permanent. 
      There is no efficient and real treatment for acute ischemia stroke so far. 
      Therefore, development of efficient therapeutic strategies is under focus of 
      investigations by basic and clinical scientists. Brain is one of the organs with 
      high energy consumption and metabolism. Hence, its functionality is highly 
      dependent on mitochondrial activity and integrity. Therefore, mitochondria play a 
      vital homeostatic role in neurons physiology and mitochondrial dysfunction 
      implications have been reported in a variety of nervous system diseases including 
      acute ischemia stroke. In an attempt to investigate and introduce a novel 
      potential therapeutic strategy for AIS, we isolated healthy mitochondria from 
      human umbilical cord derived mesenchymal stem cells (hUC-MSCs) followed by their 
      intracerebroventricular transplantation in a rat model of ischemia, i.e. middle 
      cerebral artery occlusion (MCAO). Here we report that the mitochondrial 
      transplantation ameliorated the reperfusion/ischemia-induced damages as reflected 
      by declined blood creatine phosphokinase level, abolished apoptosis, decreased 
      astroglyosis and microglia activation, reduced infarct size, and improved motor 
      function. Although further preclinical and clinical studies are required, our 
      findings strongly suggest that transplantation of MSCs-derived mitochondria is a 
      suitable, potential and efficient therapeutic option for acute ischemia stroke.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Pourmohammadi-Bejarpasi, Zahra
AU  - Pourmohammadi-Bejarpasi Z
AD  - Medical Biotechnology Department, Paramedicine Faculty, Guilan University of 
      Medical Sciences, Rasht, Iran.
FAU - Roushandeh, Amaneh Mohammadi
AU  - Roushandeh AM
AD  - Medical Biotechnology Department, Paramedicine Faculty, Guilan University of 
      Medical Sciences, Rasht, Iran; Anatomical Sciences Department, School of 
      Medicine, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: 
      mohammadi_roushandeh@gums.ac.ir.
FAU - Saberi, Alia
AU  - Saberi A
AD  - Neuroscience Research Center, Guilan University of Medical Sciences, Rasht, Iran.
FAU - Rostami, Mojdeh Kheirandish
AU  - Rostami MK
AD  - Medical Biotechnology Department, Paramedicine Faculty, Guilan University of 
      Medical Sciences, Rasht, Iran.
FAU - Toosi, Seyyed Mohammadtaghi Razavi
AU  - Toosi SMR
AD  - Medical Biotechnology Department, Paramedicine Faculty, Guilan University of 
      Medical Sciences, Rasht, Iran.
FAU - Jahanian-Najafabadi, Ali
AU  - Jahanian-Najafabadi A
AD  - Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical 
      Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Tomita, Kazuo
AU  - Tomita K
AD  - Department of Applied Pharmacology, Graduate School of Medical and Dental 
      Sciences, Kagoshima University, Kagoshima, Japan.
FAU - Kuwahara, Yoshikazu
AU  - Kuwahara Y
AD  - Division of Radiation Biology and Medicine, Faculty of Medicine, Tohoku Medical 
      and Pharmaceutical University, Sendai, Japan.
FAU - Sato, Tomoaki
AU  - Sato T
AD  - Department of Applied Pharmacology, Graduate School of Medical and Dental 
      Sciences, Kagoshima University, Kagoshima, Japan.
FAU - Roudkenar, Mehryar Habibi
AU  - Roudkenar MH
AD  - Medical Biotechnology Department, Paramedicine Faculty, Guilan University of 
      Medical Sciences, Rasht, Iran; Neuroscience Research Center, Guilan University of 
      Medical Sciences, Rasht, Iran. Electronic address: roudkenar@gums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201001
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Brain/metabolism
MH  - Disease Models, Animal
MH  - Ischemic Stroke/*metabolism
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mitochondria/metabolism
MH  - Motor Skills/*physiology
MH  - Neurons/metabolism
MH  - Rats
MH  - Reperfusion Injury/metabolism/*therapy
OTO - NOTNLM
OT  - Apoptosis
OT  - Brain stroke
OT  - Mesenchymal stems cells
OT  - Mitochondrial transplantation
EDAT- 2020/10/04 06:00
MHDA- 2021/10/27 06:00
CRDT- 2020/10/03 20:08
PHST- 2020/06/06 00:00 [received]
PHST- 2020/08/24 00:00 [revised]
PHST- 2020/09/23 00:00 [accepted]
PHST- 2020/10/04 06:00 [pubmed]
PHST- 2021/10/27 06:00 [medline]
PHST- 2020/10/03 20:08 [entrez]
AID - S0361-9230(20)30640-7 [pii]
AID - 10.1016/j.brainresbull.2020.09.018 [doi]
PST - ppublish
SO  - Brain Res Bull. 2020 Dec;165:70-80. doi: 10.1016/j.brainresbull.2020.09.018. Epub 
      2020 Oct 1.