PMID- 33010915
OWN - NLM
STAT- MEDLINE
DCOM- 20210202
LR  - 20210202
IS  - 1525-3198 (Electronic)
IS  - 0022-0302 (Linking)
VI  - 103
IP  - 12
DP  - 2020 Dec
TI  - Inflammatory diseases in dairy cows: Risk factors and associations with pregnancy 
      after embryo transfer.
PG  - 11970-11987
LID - S0022-0302(20)30773-6 [pii]
LID - 10.3168/jds.2020-19070 [doi]
AB  - The objectives of the present prospective cohort study were to identify risk 
      factors for inflammatory diseases in Holstein-Gyr crossbred dairy cows and 
      characterize the associations of those diseases with pregnancy per embryo 
      transfer (ET). Diseases were diagnosed in the first 60 d postpartum in 252 
      primiparous and 481 multiparous cows. Uterine diseases (UTD) included retained 
      placenta, metritis, clinical endometritis, and subclinical endometritis. 
      Nonuterine diseases (NUTD) included mastitis, lameness, pneumonia, and displaced 
      abomasum. Blood was sampled on d 0, 1, and 2 postpartum and analyzed for 
      concentrations of haptoglobin, fatty acids, total Ca (tCa), P, and Mg, and again 
      on d 8 postpartum and analyzed for concentration of beta-hydroxybutyrate. The 
      association between concentrations of metabolites in serum and inflammatory 
      diseases was determined. Cows received a timed ET program starting 28 +/- 3 d 
      postpartum with first ET at 46 +/- 3 d postpartum using fresh in vitro-produced 
      embryos. Pregnancy was diagnosed on d 31 and 59 of presumptive gestation. 
      Overall, 63.3% of the cows were diagnosed with UTD and 20.6% with NUTD. The risk 
      factors for UTD included season of calving, parity group, calving problems, days 
      with subclinical hypocalcemia, and serum concentrations of haptoglobin and Mg, 
      whereas the risk factors for NUTD were parity group and serum Mg concentration. 
      Cows that developed UTD had increased concentrations of haptoglobin on d 2 and 
      fatty acids on d 1 and 2, and reduced concentrations of tCa on d 1 and 2 and of P 
      and Mg on d 2 postpartum compared with cows without UTD. Cows that developed NUTD 
      had increased concentrations of fatty acids on d 0 to 2 postpartum, and decreased 
      concentrations of tCa and P on d 0 and 1, and of Mg on d 1 and 2 postpartum 
      compared with cows without NUTD. Cows that developed NUTD had a 340-kg reduction 
      in milk yield in the first 60 d postpartum. Inflammatory diseases were associated 
      with lesser body condition score and increased loss of body condition in the 
      first 70 d postpartum. Maintenance of pregnancy after ET was reduced in UTD cows 
      following the first (41.7 vs. 25.4%) or all ET (46.4 vs. 36.2%), whereas 
      maintenance of pregnancy was reduced in NUTD cows only at the second ET (39.0 vs 
      25.9%). The reduced pregnancy maintenance in UTD cows combined with a reduced 
      21-d service rate (61.9 vs. 54.8%) decreased the 21-d cycle pregnancy rate (28.6 
      vs. 19.9%) and the hazard of pregnancy to 300 d postpartum by 35%, resulting in 
      an extra 32 d open. In conclusion, inflammatory diseases depressed fertility in 
      dairy cows receiving ET, with the greatest impact observed in UTD cows. This 
      suggests that local inflammation of the uterus impairs maintenance of pregnancy 
      in dairy cows following ET.
CI  - Copyright (c) 2020 American Dairy Science Association. Published by Elsevier Inc. 
      All rights reserved.
FAU - Edelhoff, I N F
AU  - Edelhoff INF
AD  - Department of Animal Sciences, University of Florida, Gainesville 32611; 
      Department of Animal Production, Sao Paulo State University, Botucatu, Brazil 
      18168.
FAU - Pereira, M H C
AU  - Pereira MHC
AD  - Department of Animal Production, Sao Paulo State University, Botucatu, Brazil 
      18168.
FAU - Bromfield, J J
AU  - Bromfield JJ
AD  - Department of Animal Sciences, University of Florida, Gainesville 32611; DH 
      Barron Reproductive and Perinatal Biology Research Program, University of 
      Florida, Gainesville 32611.
FAU - Vasconcelos, J L M
AU  - Vasconcelos JLM
AD  - Department of Animal Production, Sao Paulo State University, Botucatu, Brazil 
      18168.
FAU - Santos, J E P
AU  - Santos JEP
AD  - Department of Animal Sciences, University of Florida, Gainesville 32611; DH 
      Barron Reproductive and Perinatal Biology Research Program, University of 
      Florida, Gainesville 32611. Electronic address: jepsantos@ufl.edu.
LA  - eng
PT  - Journal Article
DEP - 20201001
PL  - United States
TA  - J Dairy Sci
JT  - Journal of dairy science
JID - 2985126R
RN  - 0 (Haptoglobins)
RN  - TZP1275679 (3-Hydroxybutyric Acid)
SB  - IM
MH  - 3-Hydroxybutyric Acid/blood
MH  - Animals
MH  - Cattle
MH  - Cattle Diseases/*etiology/metabolism
MH  - Embryo Transfer/adverse effects/*veterinary
MH  - Endometritis/veterinary
MH  - Female
MH  - Fertility
MH  - Haptoglobins/metabolism
MH  - Hypocalcemia/veterinary
MH  - Inflammation/etiology/*veterinary
MH  - Lactation
MH  - Milk
MH  - Parity
MH  - Placenta, Retained/veterinary
MH  - Postpartum Period/metabolism
MH  - Pregnancy
MH  - Pregnancy Complications/etiology/*veterinary
MH  - Prospective Studies
MH  - Risk Factors
MH  - Uterine Diseases/veterinary
OTO - NOTNLM
OT  - dairy cow
OT  - embryo transfer
OT  - inflammation
OT  - reproduction
EDAT- 2020/10/05 06:00
MHDA- 2021/02/03 06:00
CRDT- 2020/10/04 20:20
PHST- 2020/06/10 00:00 [received]
PHST- 2020/07/14 00:00 [accepted]
PHST- 2020/10/05 06:00 [pubmed]
PHST- 2021/02/03 06:00 [medline]
PHST- 2020/10/04 20:20 [entrez]
AID - S0022-0302(20)30773-6 [pii]
AID - 10.3168/jds.2020-19070 [doi]
PST - ppublish
SO  - J Dairy Sci. 2020 Dec;103(12):11970-11987. doi: 10.3168/jds.2020-19070. Epub 2020 
      Oct 1.