PMID- 33011523
OWN - NLM
STAT- MEDLINE
DCOM- 20211005
LR  - 20211005
IS  - 1872-7484 (Electronic)
IS  - 1566-0702 (Print)
IS  - 1566-0702 (Linking)
VI  - 229
DP  - 2020 Dec
TI  - Is there cardiac autonomic neuropathy in prediabetes?
PG  - 102722
LID - S1566-0702(20)30156-9 [pii]
LID - 10.1016/j.autneu.2020.102722 [doi]
AB  - Although there is considerably more data showing an association between type 2 
      diabetes mellitus (T2DM) and autonomic neuropathy, accumulating evidence 
      indicates that cardiovascular autonomic neuropathy (CAN) is common in persons 
      with impaired glucose tolerance (IGT). Furthermore, CAN may occur early after a 
      metabolic insult and obesity, especially among mean, and seems to play an 
      important role in the early pathogenesis of CAN. Autonomic symptoms are common in 
      subjects with IGT. In addition to defects in CAN, in subjects with IGT, there is 
      impaired sudomotor function and abnormalities of endothelial peripheral 
      vasoreactivity. At the present time, the only interventions that may be effective 
      in preventing or reversing IGT associated autonomic neuropathy are lifestyle 
      improvement. These include a tailored diet and exercise program. Other approaches 
      that may be beneficial include modulation of oxidative stress and improvement of 
      metabolic regulation in subjects with IGT. Interventions are most likely to be 
      effective early in the course of disease and therefore it is extremely important 
      to have early diagnosis of IGT and autonomic neuropathy.
CI  - Copyright (c) 2020. Published by Elsevier B.V.
FAU - Zilliox, Lindsay A
AU  - Zilliox LA
AD  - Department of Neurology, University of Maryland and Maryland VA Healthcare 
      System, Baltimore, MD, United States of America.
FAU - Russell, James W
AU  - Russell JW
AD  - Department of Neurology, University of Maryland and Maryland VA Healthcare 
      System, Baltimore, MD, United States of America. Electronic address: 
      JRussell@som.umaryland.edu.
LA  - eng
GR  - I01 RX001030/RX/RRD VA/United States
GR  - IK2 RX001651/RX/RRD VA/United States
GR  - P30 DK072488/DK/NIDDK NIH HHS/United States
GR  - R01 DK107007/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20200911
PL  - Netherlands
TA  - Auton Neurosci
JT  - Autonomic neuroscience : basic & clinical
JID - 100909359
SB  - IM
MH  - Autonomic Nervous System Diseases/*etiology/*physiopathology/*therapy
MH  - Diabetic Neuropathies/*etiology
MH  - Heart Diseases/*etiology
MH  - Humans
MH  - Prediabetic State/*complications
PMC - PMC7704909
MID - NIHMS1639854
OTO - NOTNLM
OT  - Autonomic
OT  - Diabetes
OT  - Impaired glucose tolerance
OT  - Neuropathy
EDAT- 2020/10/05 06:00
MHDA- 2021/10/06 06:00
PMCR- 2020/12/01
CRDT- 2020/10/04 20:27
PHST- 2019/08/06 00:00 [received]
PHST- 2020/06/09 00:00 [revised]
PHST- 2020/08/24 00:00 [accepted]
PHST- 2020/10/05 06:00 [pubmed]
PHST- 2021/10/06 06:00 [medline]
PHST- 2020/10/04 20:27 [entrez]
PHST- 2020/12/01 00:00 [pmc-release]
AID - S1566-0702(20)30156-9 [pii]
AID - 10.1016/j.autneu.2020.102722 [doi]
PST - ppublish
SO  - Auton Neurosci. 2020 Dec;229:102722. doi: 10.1016/j.autneu.2020.102722. Epub 2020 
      Sep 11.