PMID- 33014123
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240329
IS  - 1749-8546 (Print)
IS  - 1749-8546 (Electronic)
IS  - 1749-8546 (Linking)
VI  - 15
DP  - 2020
TI  - Hejie Zhitong prescription promotes sleep and inhibits nociceptive 
      transmission-associated neurotransmitter activity in a rodent migraine model.
PG  - 105
LID - 10.1186/s13020-020-00386-y [doi]
LID - 105
AB  - BACKGROUND: Migraine is painful disease in which neurotransmitters related to 
      pain transmission play an important role. Hejie Zhitong prescription (HJZT) has 
      been used in the clinic as an effective prescription for the treatment of 
      migraine for many years. Our team aimed to further explore its antimigraine 
      mechanism based on previous research results and to explore the inhibitory effect 
      of HJZT on the transmission of pain related to nitroglycerine (NTG)-induced 
      migraine as well as the synergistic effect of HJZT with pentobarbital sodium on 
      promoting sleep. METHODS: Sixty mice were randomly assigned to groups and 
      received the corresponding interventions. Sleep latency and sleep time were 
      recorded to calculate the incidence of sleep. Forty-eight Wistar rats were 
      randomly assigned and administered an intervention corresponding to their group. 
      Calcitonin gene-related peptide (CGRP), serotonin (5-HT), substance P (SP), and 
      cholecystokinin (CCK) levels were measured using ELISAs. Levels of the 
      cannabinoid receptor type 1 (CB1R) and cyclooxygenase-2 (COX-2) protein were 
      assessed using immunohistochemistry. The expression of the CGRP and CCK mRNAs in 
      the midbrain and trigeminal ganglion (TG) were measured using real-time 
      quantitative PCR. RESULTS: HJZT promoted the occurrence of sleep in mice. HJZT 
      downregulated COX-2 expression in the midbrain and TG of rats but upregulated the 
      expression of the CB1R, and decreased the plasma level of the CGRP protein and 
      expression of its mRNA in the midbrain and TG. It also downregulated the 
      expression of the CCK mRNA in the midbrain and TG. The high-dose HJZT treatment 
      increased plasma 5-HT levels, but did not induce changes in the plasma levels of 
      the SP or CCK protein. CONCLUSIONS: HJZT exerts a synergistic effect with 
      pentobarbital sodium on promoting sleep. As for anti-migraine, HJZT can inhibits 
      the expression of nociceptive transmission-associated neurotransmitters, 
      including 5-HT, CGRP and CCK, which may be related to its upregulation of CB1R 
      and downregulation of COX-2.
CI  - (c) The Author(s) 2020.
FAU - Wang, Xinna
AU  - Wang X
AD  - Changchun University of Traditional Chinese Medicine, Changchun, Jilin, 130117 
      China.
FAU - Zhao, Hongfei
AU  - Zhao H
AD  - Administration of Traditional Chinese Medicine of Jilin Province, Changchun, 
      Jilin, 130051 China.
FAU - Liu, Liming
AU  - Liu L
AD  - Changchun University of Traditional Chinese Medicine, Changchun, Jilin, 130117 
      China.
FAU - Niu, Ping
AU  - Niu P
AD  - Changchun University of Traditional Chinese Medicine, Changchun, Jilin, 130117 
      China.
FAU - Zhai, Chao
AU  - Zhai C
AD  - Changchun University of Traditional Chinese Medicine, Changchun, Jilin, 130117 
      China.
FAU - Li, Jinjian
AU  - Li J
AD  - Changchun University of Traditional Chinese Medicine, Changchun, Jilin, 130117 
      China.
FAU - Xu, Qiaoli
AU  - Xu Q
AD  - Changchun University of Traditional Chinese Medicine, Changchun, Jilin, 130117 
      China.
FAU - Zhao, Dexi
AU  - Zhao D
AD  - Changchun University of Traditional Chinese Medicine, Changchun, Jilin, 130117 
      China.
LA  - eng
PT  - Journal Article
DEP - 20200929
PL  - England
TA  - Chin Med
JT  - Chinese medicine
JID - 101265109
PMC - PMC7526328
OTO - NOTNLM
OT  - Hejie Zhitong prescription
OT  - Migraine
OT  - Nociceptive transmission-associated neurotransmitter
OT  - Sleep
COIS- Competing interestsThe authors have no competing interests to declare.
EDAT- 2020/10/06 06:00
MHDA- 2020/10/06 06:01
PMCR- 2020/09/29
CRDT- 2020/10/05 06:17
PHST- 2020/06/29 00:00 [received]
PHST- 2020/09/20 00:00 [accepted]
PHST- 2020/10/05 06:17 [entrez]
PHST- 2020/10/06 06:00 [pubmed]
PHST- 2020/10/06 06:01 [medline]
PHST- 2020/09/29 00:00 [pmc-release]
AID - 386 [pii]
AID - 10.1186/s13020-020-00386-y [doi]
PST - epublish
SO  - Chin Med. 2020 Sep 29;15:105. doi: 10.1186/s13020-020-00386-y. eCollection 2020.