PMID- 33014578
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2156-7085 (Print)
IS  - 2156-7085 (Electronic)
IS  - 2156-7085 (Linking)
VI  - 11
IP  - 7
DP  - 2020 Jul 1
TI  - Sensorless adaptive-optics optical coherence tomographic angiography.
PG  - 3952-3967
LID - 10.1364/BOE.396829 [doi]
AB  - Optical coherence tomographic angiography (OCTA) can image the retinal blood flow 
      but visualization of the capillary caliber is limited by the low lateral 
      resolution. Adaptive optics (AO) can be used to compensate ocular aberrations 
      when using high numerical aperture (NA), and thus improve image resolution. 
      However, previously reported AO-OCTA instruments were large and complex, and have 
      a small sub-millimeter field of view (FOV) that hinders the extraction of 
      biomarkers with clinical relevance. In this manuscript, we developed a sensorless 
      AO-OCTA prototype with an intermediate numerical aperture to produce 
      depth-resolved angiograms with high resolution and signal-to-noise ratio over a 
      2 x 2 mm FOV, with a focal spot diameter of 6 microm, which is about 3 times finer 
      than typical commercial OCT systems. We believe these parameters may represent a 
      better tradeoff between resolution and FOV compared to large-NA AO systems, since 
      the spot size matches better that of capillaries. The prototype corrects defocus, 
      astigmatism, and coma using a figure of merit based on the mean reflectance 
      projection of a slab defined with real-time segmentation of retinal layers. AO 
      correction with the ability to optimize focusing in arbitrary retinal depths - 
      particularly the plexuses in the inner retina - could be achieved in 1.35 
      seconds. The AO-OCTA images showed greater flow signal, signal-to-noise ratio, 
      and finer capillary caliber compared to commercial OCTA. Projection artifacts 
      were also reduced in the intermediate and deep capillary plexuses. The instrument 
      reported here improves OCTA image quality without excessive sacrifice in FOV and 
      device complexity, and thus may have potential for clinical translation.
CI  - (c) 2020 Optical Society of America under the terms of the OSA Open Access 
      Publishing Agreement.
FAU - Camino, Acner
AU  - Camino A
AD  - Casey Eye Institute, Oregon Health & Science University, Portland, OR 27239, USA.
FAU - Zang, Pengxiao
AU  - Zang P
AD  - Casey Eye Institute, Oregon Health & Science University, Portland, OR 27239, USA.
FAU - Athwal, Arman
AU  - Athwal A
AD  - Department of Engineering Science, Simon Fraser University, Burnaby, Canada.
FAU - Ni, Shuibin
AU  - Ni S
AD  - Casey Eye Institute, Oregon Health & Science University, Portland, OR 27239, USA.
FAU - Jia, Yali
AU  - Jia Y
AUID- ORCID: 0000-0002-2784-1905
AD  - Casey Eye Institute, Oregon Health & Science University, Portland, OR 27239, USA.
AD  - Department of Biomedical Engineering, Oregon Health & Science University, 
      Portland, OR 97239, USA.
FAU - Huang, David
AU  - Huang D
AD  - Casey Eye Institute, Oregon Health & Science University, Portland, OR 27239, USA.
FAU - Jian, Yifan
AU  - Jian Y
AD  - Casey Eye Institute, Oregon Health & Science University, Portland, OR 27239, USA.
LA  - eng
GR  - P30 EY010572/EY/NEI NIH HHS/United States
GR  - R01 EY024544/EY/NEI NIH HHS/United States
GR  - R01 EY027833/EY/NEI NIH HHS/United States
PT  - Journal Article
DEP - 20200624
PL  - United States
TA  - Biomed Opt Express
JT  - Biomedical optics express
JID - 101540630
PMC - PMC7510908
COIS- Acner Camino: Optovue, Inc (P). Yali Jia: Optovue, Inc (F, P). David Huang: 
      Optovue, Inc (F, I, P, R), Yifan Jian: Seymour Vision (I). These potential 
      conflicts of interest have been reviewed and managed by OHSU. Other authors 
      declare that there are no conflicts of interest related to this article.
EDAT- 2020/10/06 06:00
MHDA- 2020/10/06 06:01
PMCR- 2020/07/01
CRDT- 2020/10/05 06:19
PHST- 2020/05/04 00:00 [received]
PHST- 2020/06/15 00:00 [revised]
PHST- 2020/06/16 00:00 [accepted]
PHST- 2020/10/05 06:19 [entrez]
PHST- 2020/10/06 06:00 [pubmed]
PHST- 2020/10/06 06:01 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - 396829 [pii]
AID - 10.1364/BOE.396829 [doi]
PST - epublish
SO  - Biomed Opt Express. 2020 Jun 24;11(7):3952-3967. doi: 10.1364/BOE.396829. 
      eCollection 2020 Jul 1.