PMID- 33014833
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220417
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 10
DP  - 2020
TI  - Radiotherapy Versus Surgery-Which Is Better for Patients With T1-2N0M0 Glottic 
      Laryngeal Squamous Cell Carcinoma? Individualized Survival Prediction Based on 
      Web-Based Nomograms.
PG  - 1669
LID - 10.3389/fonc.2020.01669 [doi]
LID - 1669
AB  - BACKGROUND: Both radiotherapy and surgery are now recommended for early stage 
      glottic laryngeal squamous cell carcinoma (LSCC), and both have their own 
      advantages in patients with different characteristics. For each patient, it is 
      hard to determine whether radiotherapy or surgery is more appropriate. METHODS: 
      Patients with T1-2N0M0 glottic LSCC who received radiotherapy or surgery in the 
      2004-2016 SEER database were reviewed, then randomly divided into training and 
      validation cohorts. Propensity score matching was used to eliminate the baseline 
      variations, and competing risk analyses helped to exclude the effects of other 
      causes of death. Based on univariate and multivariate analyses, we built two 
      nomograms to visually predict the survival of each patient with different 
      characteristics who received radiotherapy or surgery, then validated the accuracy 
      in both training and validation cohorts. Using nomogramEx, we quantified the 
      algorithms of the nomograms and put the nomograms on the websites. RESULTS: A 
      total of 6538 patients in the SEER database were included. We found that therapy 
      (p = 0.004), T stage (p < 0.001), age (p < 0.001), race (p < 0.044), grade (p = 
      0.001), and marital status (p < 0.001) were independent prognostic factors. Two 
      nomograms were built to calculate the survival for each patient who received 
      radiotherapy (C-index = 0.668 +/- 0.050 in the training cohort and 0.578 +/- 0.028 in 
      the validation cohort) or underwent surgery (C-index = 0.772 +/- 0.045 in the 
      training cohort and 0.658 +/- 0.090 in the validation cohort). Calibration plots 
      showed the accuracy of the nomograms. Using the nomograms, we found that 3872 
      patients (59.22%) had no difference between the two therapies, 706 patients 
      (10.80%) who received radiotherapy had better survival outcomes, and 1960 
      patients (29.98%) who underwent surgery had better survival outcome. CONCLUSION: 
      Nomograms were used to comprehensively calculate independent factors to determine 
      which treatment (radiotherapy or surgery) is better for each patient. A website 
      was used to offer guidance regarding surgery or radiation for patients and 
      physicians.
CI  - Copyright (c) 2020 Du, Shao, Lv, Zhu, Yan and Qiao.
FAU - Du, Yajing
AU  - Du Y
AD  - Center for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Shao, Shali
AU  - Shao S
AD  - Center for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Lv, Minghe
AU  - Lv M
AD  - Center for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Zhu, Yi
AU  - Zhu Y
AD  - Department of Radiation Oncology, Eye and ENT Hospital, Fudan University, 
      Shanghai, China.
FAU - Yan, Li
AU  - Yan L
AD  - Department of Radiation Oncology, Eye and ENT Hospital, Fudan University, 
      Shanghai, China.
FAU - Qiao, Tiankui
AU  - Qiao T
AD  - Center for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20200826
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC7507900
OTO - NOTNLM
OT  - SEER
OT  - glottic laryngeal squamous cell carcinoma
OT  - nomogram
OT  - radiotherapy
OT  - surgery
EDAT- 2020/10/06 06:00
MHDA- 2020/10/06 06:01
PMCR- 2020/01/01
CRDT- 2020/10/05 06:20
PHST- 2020/02/26 00:00 [received]
PHST- 2020/07/28 00:00 [accepted]
PHST- 2020/10/05 06:20 [entrez]
PHST- 2020/10/06 06:00 [pubmed]
PHST- 2020/10/06 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2020.01669 [doi]
PST - epublish
SO  - Front Oncol. 2020 Aug 26;10:1669. doi: 10.3389/fonc.2020.01669. eCollection 2020.