PMID- 33014899
OWN - NLM
STAT- MEDLINE
DCOM- 20210517
LR  - 20210517
IS  - 2235-2988 (Electronic)
IS  - 2235-2988 (Linking)
VI  - 10
DP  - 2020
TI  - Inflammasome Fuels Dengue Severity.
PG  - 489
LID - 10.3389/fcimb.2020.00489 [doi]
LID - 489
AB  - Dengue is an acute febrile disease triggered by dengue virus. Dengue is the 
      widespread and rapidly transmitted mosquito-borne viral disease of humans. 
      Diverse symptoms and diseases due to Dengue virus (DENV) infection ranges from 
      dengue fever, dengue hemorrhagic fever (life-threatening) and dengue shock 
      syndrome characterized by shock, endothelial dysfunction and vascular leakage. 
      Several studies have linked the severity of dengue with the induction of 
      inflammasome. DENV activates the NLRP3-specific inflammasome in DENV infected 
      human patients, mice; specifically, mouse bone marrow derived macrophages 
      (BMDMs), dendritic cells, endothelial cells, human peripheral blood mononuclear 
      cells (PBMCs), keratinocytes, monocyte-differentiated macrophages (THP-1), and 
      platelets. Dengue virus mediated inflammasome initiates the maturation of IL-1beta 
      and IL-18, which are critical for dengue pathology and inflammatory response. 
      Several studies have reported the molecular mechanism through which (host and 
      viral factors) dengue induces inflammasome, unravels the possible mechanisms of 
      DENV pathogenesis and sets up the stage for the advancement of DENV therapeutics. 
      In this perspective article, we discuss the potential implications and our 
      understanding of inflammasome mechanisms of dengue virus and highlight research 
      areas that have potential to inhibit the pathogenesis of viral diseases, 
      specifically for dengue.
CI  - This work is authored by Eric Calvo, Paola Valenzuela Leon and Gaurav Shrivastava 
      on behalf of the U.S. Government and, as regards Drs. Calvo, Valenzuela Leon and 
      Shrivastava and the U.S. Government, is not subject to copyright protection in 
      the United States. Foreign and other copyrights may apply.
FAU - Shrivastava, Gaurav
AU  - Shrivastava G
AD  - Laboratory of Malaria and Vector Research, National Institute of Allergy and 
      Infectious Diseases, National Institutes of Health, Rockville, MD, United States.
FAU - Valenzuela Leon, Paola Carolina
AU  - Valenzuela Leon PC
AD  - Laboratory of Malaria and Vector Research, National Institute of Allergy and 
      Infectious Diseases, National Institutes of Health, Rockville, MD, United States.
FAU - Calvo, Eric
AU  - Calvo E
AD  - Laboratory of Malaria and Vector Research, National Institute of Allergy and 
      Infectious Diseases, National Institutes of Health, Rockville, MD, United States.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20200910
PL  - Switzerland
TA  - Front Cell Infect Microbiol
JT  - Frontiers in cellular and infection microbiology
JID - 101585359
RN  - 0 (Inflammasomes)
SB  - IM
MH  - Animals
MH  - *Dengue
MH  - *Dengue Virus/pathogenicity
MH  - Endothelial Cells
MH  - Humans
MH  - *Inflammasomes
MH  - Leukocytes, Mononuclear
MH  - Mice
MH  - Severity of Illness Index
PMC - PMC7511630
OTO - NOTNLM
OT  - IL-1beta
OT  - NLRP3 inflammasome
OT  - cytokine storm
OT  - dengue (DENV)
OT  - innate immune response
OT  - mosquito borne disease
OT  - pyroptosis
OT  - vascular leakage
EDAT- 2020/10/06 06:00
MHDA- 2021/05/18 06:00
PMCR- 2020/01/01
CRDT- 2020/10/05 06:21
PHST- 2020/06/09 00:00 [received]
PHST- 2020/08/06 00:00 [accepted]
PHST- 2020/10/05 06:21 [entrez]
PHST- 2020/10/06 06:00 [pubmed]
PHST- 2021/05/18 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fcimb.2020.00489 [doi]
PST - epublish
SO  - Front Cell Infect Microbiol. 2020 Sep 10;10:489. doi: 10.3389/fcimb.2020.00489. 
      eCollection 2020.