PMID- 33015330
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201006
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 8
IP  - 10
DP  - 2020 Oct
TI  - Full-thickness resection device (FTRD) for treatment of upper gastrointestinal 
      tract lesions: the first international experience.
PG  - E1291-E1301
LID - 10.1055/a-1216-1439 [doi]
AB  - Background and study aims  The Full-Thickness Resection Device (FTRD) provides a 
      novel treatment option for lesions not amenable to conventional endoscopic 
      resection techniques. There are limited data on the efficacy and safety of FTRD 
      for resection of upper gastrointestinal tract (GIT) lesions. Patients and 
      methods  This was an international multicenter retrospective study, including 
      patients who had an endoscopic resection of an upper GIT lesion using the FTRD 
      between January 2017 and February 2019. Results  Fifty-six patients from 13 
      centers were included. The most common lesions were mesenchymal neoplasms 
      (n = 23, 41 %), adenomas (n = 7, 13 %), and hamartomas (n = 6, 11 %). Eighty-four 
      percent of lesions were located in the stomach, and 14 % in the duodenum. The 
      average size of lesions was 14 mm (range 3 to 33 mm). Deployment of the FTRD was 
      technically successful in 93 % of patients (n = 52) leading to complete and 
      partial resection in 43 (77 %) and 9 (16 %) patients, respectively. Overall, the 
      FTRD led to negative histological margins (R0 resection) in 38 (68 %) of 
      patients. A total of 12 (21 %) mild or moderate adverse events (AEs) were 
      reported. Follow-up endoscopy was performed in 31 patients (55 %), on average 88 
      days after the procedure (IQR 68-138 days). Of these, 30 patients (97 %) did not 
      have any residual or recurrent lesion on endoscopic examination and biopsy, with 
      residual adenoma in one patient (3 %). Conclusions  Our results suggest a high 
      technical success rate and an acceptable histologically complete resection rate, 
      with a low risk of AEs and early recurrence for FTRD resection of upper GIT 
      lesions.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution-NonDerivative-NonCommercial License, 
      permitting copying and reproduction so long as the original work is given 
      appropriate credit. Contents may not be used for commecial purposes, or adapted, 
      remixed, transformed or built upon. 
      (https://creativecommons.org/licenses/by-nc-nd/4.0/).
FAU - Hajifathalian, Kaveh
AU  - Hajifathalian K
AD  - Weill Cornell Medicine, Division of Gastroenterology and Hepatology, Department 
      of Medicine, New York, NY.
FAU - Ichkhanian, Yervant
AU  - Ichkhanian Y
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, Maryland, United 
      States.
FAU - Dawod, Qais
AU  - Dawod Q
AD  - Weill Cornell Medicine, Division of Gastroenterology and Hepatology, Department 
      of Medicine, New York, NY.
FAU - Meining, Alexander
AU  - Meining A
AD  - Interventional and Experimental Endoscopy, Department of Internal Medicine I, Ulm 
      University, Ulm, Germany.
FAU - Schmidt, Arthur
AU  - Schmidt A
AD  - Department of Medicine II, Medical Center, University of Freiburg, Faculty of 
      Medicine, Freiburg, Germany.
FAU - Glaser, Nicholas
AU  - Glaser N
AD  - Department of Medicine II, Medical Center, University of Freiburg, Faculty of 
      Medicine, Freiburg, Germany.
FAU - Vosoughi, Kia
AU  - Vosoughi K
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, Maryland, United 
      States.
FAU - Diehl, David L
AU  - Diehl DL
AD  - Interventional and Experimental Endoscopy, Department of Internal Medicine I, Ulm 
      University, Ulm, Germany.
FAU - Grimm, Ian S
AU  - Grimm IS
AD  - Department of Gastroenterology and Nutrition, Geisinger Medical Center, Danville, 
      Pennsylvania, United States.
FAU - James, Theodore
AU  - James T
AD  - Division of Gastroenterology and Hepatology, University of North Carolina, Chapel 
      Hill, North Carolina, United States.
FAU - Templeton, Adam W
AU  - Templeton AW
AD  - Department of Gastroenterology, University of Washington, Seattle, Washington, 
      United States.
FAU - Samarasena, Jason B
AU  - Samarasena JB
AD  - H. H. Chao Comprehensive Digestive Disease Center, Division of Gastroenterology 
      and Hepatology, University of California, Irvine, Orange, California, United 
      States.
FAU - Chehade, Nabil El Hage
AU  - Chehade NEH
AD  - H. H. Chao Comprehensive Digestive Disease Center, Division of Gastroenterology 
      and Hepatology, University of California, Irvine, Orange, California, United 
      States.
FAU - Lee, John G
AU  - Lee JG
AD  - H. H. Chao Comprehensive Digestive Disease Center, Division of Gastroenterology 
      and Hepatology, University of California, Irvine, Orange, California, United 
      States.
FAU - Chang, Kenneth J
AU  - Chang KJ
AD  - H. H. Chao Comprehensive Digestive Disease Center, Division of Gastroenterology 
      and Hepatology, University of California, Irvine, Orange, California, United 
      States.
FAU - Mizrahi, Meir
AU  - Mizrahi M
AD  - Department of Internal Medicine, Division of Gastroenterology, Center for 
      Advanced Endoscopy, University of South Alabama, Mobile, Alabama, United States.
FAU - Barawi, Mohammed
AU  - Barawi M
AD  - Division of Gastroenterology and Hepatology, Ascension St. John hospital, 
      Detroit, Michigan, United States.
FAU - Irani, Shayan
AU  - Irani S
AD  - Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington, 
      United Stats.
FAU - Friedland, Shai
AU  - Friedland S
AD  - Division of Gastroenterology and Hepatology, Stanford University School of 
      Medicine, Stanford, California, United States.
FAU - Korc, Paul
AU  - Korc P
AD  - Department of Medicine, Division of Gastroenterology, Hoag Hospital, Newport 
      Beach, California, United States.
FAU - Aadam, Abdul Aziz
AU  - Aadam AA
AD  - Division of Gastroenterology, Northwestern University, Chicago, Illinois, United 
      States.
FAU - Al-Haddad, Mohammad
AU  - Al-Haddad M
AD  - Indiana University School of Medicine, Department of Medicine, Division of 
      Gastroenterology, Indianapolis, Indiana, United States.
FAU - Kowalski, Thomas E
AU  - Kowalski TE
AD  - Thomas Jefferson University, Philadelphia, Pennsylvania, United States.
FAU - Smallfield, George
AU  - Smallfield G
AD  - Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth 
      University, Richmond, Virginia United States.
FAU - Ginsberg, Gregory G
AU  - Ginsberg GG
AD  - Gastroenterology Division, University of Pennsylvania, Perelman School of 
      Medicine, Philadelphia, Pennsylvania, United States.
FAU - Fukami, Norio
AU  - Fukami N
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Scottsdale, 
      Arizona, United States.
FAU - Lajin, Michael
AU  - Lajin M
AD  - SHARP Grossmont Hospital, La Mesa, California, United States.
FAU - Kumta, Nikhil A
AU  - Kumta NA
AD  - Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at 
      Mount Sinai, New York, New York, United States.
FAU - Tang, Shou-Jiang
AU  - Tang SJ
AD  - Division of Digestive Diseases, Department of Medicine, University of Mississippi 
      Medical Center, Jackson, Mississippi, United States.
FAU - Naga, Yehia
AU  - Naga Y
AD  - Division of Digestive Diseases, Department of Medicine, University of Mississippi 
      Medical Center, Jackson, Mississippi, United States.
FAU - Amateau, Stuart K
AU  - Amateau SK
AD  - Division of Gastroenterology, University of Minnesota, Minneapolis, Minnesota, 
      United States.
FAU - Kasmin, Franklin
AU  - Kasmin F
AD  - Division of Gastroenterology, Lenox Hill Hospital, Northwell Health, New York, 
      New York, United States.
FAU - Goetz, Martin
AU  - Goetz M
AD  - Innere Medizin I, Universitatsklinikum Tubingen, Tuebingen, Germany.
FAU - Seewald, Stefan
AU  - Seewald S
AD  - Centre of Gastroenterology, Klinik Hirslanden, Zurich, Switzerland.
FAU - Kumbhari, Vivek
AU  - Kumbhari V
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, Maryland, United 
      States.
FAU - Ngamruengphong, Saowanee
AU  - Ngamruengphong S
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, Maryland, United 
      States.
FAU - Mahdev, Srihari
AU  - Mahdev S
AD  - Weill Cornell Medicine, Division of Gastroenterology and Hepatology, Department 
      of Medicine, New York, NY.
FAU - Mukewar, Saurabh
AU  - Mukewar S
AD  - Weill Cornell Medicine, Division of Gastroenterology and Hepatology, Department 
      of Medicine, New York, NY.
FAU - Sampath, Kartik
AU  - Sampath K
AD  - Weill Cornell Medicine, Division of Gastroenterology and Hepatology, Department 
      of Medicine, New York, NY.
FAU - Carr-Locke, David L
AU  - Carr-Locke DL
AD  - Weill Cornell Medicine, Division of Gastroenterology and Hepatology, Department 
      of Medicine, New York, NY.
FAU - Khashab, Mouen A
AU  - Khashab MA
AD  - Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, Maryland, United 
      States.
FAU - Sharaiha, Reem Z
AU  - Sharaiha RZ
AD  - Weill Cornell Medicine, Division of Gastroenterology and Hepatology, Department 
      of Medicine, New York, NY.
LA  - eng
PT  - Journal Article
DEP - 20200922
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC7508667
COIS- Competing interests Dr. Khashab is a consultant for Boston Scientific, Medtronic 
      and Olympus. Dr. Grimm is a consultant for Boston Scientific. Dr. Irani is a 
      consultant for Boston Scientific. Dr. Kumbhari is a consultant for ReShape Life 
      Sciences, Apollo Endosurgery, Medtronic, and Boston Scientific. Dr. Nikhil is a 
      consultant for Apollo Endosurgery, Boston scientific, and Olympus. Dr. Amateau is 
      a consultant for Merit Endoscopy, Boston Scientific, US Endoscopy, and 
      Neurotronic and the recipient of research support from Cook Medical. Dr. 
      Smallfield has research funding from CSA Medical and C2 Therapeutics. Dr. Aadam 
      is a consultant for Boston Scientific. Dr. Diehl is a consultant for Boston 
      Scientific, Olympus, Pentax, and Cook Medical. Dr. Chang is a consultant for 
      Apollo, Boston Scientific, Cook, Covidien, Erbe, Endogastric Solutions, Mauna Kea 
      Technologies, Mederi, Medtronic, Olympus, Ovesco, Pentax, and Torax. Dr. 
      Samarasena has an educational grant from Cook and is a consultant for Mauna Kea 
      Technologies, Medtronic, Olympus, Pentax, and US Endoscopy. Dr. Al-Haddad 
      received research and teaching support from Boston Scientific. Dr. Friedland is a 
      consultant for Boston Scientific and CapsoVision. Dr. Templeton is a consultant 
      for Boston Scientific and Medtronic. Dr. Ginsberg is a consultant for Olympus and 
      Boston Scientific. Dr. Fukami is a consultant for Boston Scientific and Olympus. 
      Dr. Mahadev is a consultant for Olympus and Conmed. Dr Sharaiha is a consultant 
      for Olympus, Boston Scientific, and Cook. Dr Carr-Locke is a consultant for 
      Boston Scientific Endoscopy and receives royalties from Steris Corporation and 
      Telemed Systems. Dr. Schmidt has received lecture fees and research funding from 
      Ovesco Endoscopy.
EDAT- 2020/10/06 06:00
MHDA- 2020/10/06 06:01
PMCR- 2020/10/01
CRDT- 2020/10/05 06:22
PHST- 2020/03/03 00:00 [received]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/10/05 06:22 [entrez]
PHST- 2020/10/06 06:00 [pubmed]
PHST- 2020/10/06 06:01 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - 10.1055/a-1216-1439 [doi]
PST - ppublish
SO  - Endosc Int Open. 2020 Oct;8(10):E1291-E1301. doi: 10.1055/a-1216-1439. Epub 2020 
      Sep 22.