PMID- 33015335
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201006
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 8
IP  - 10
DP  - 2020 Oct
TI  - Efficacy of transoral outlet reduction in Roux-en-Y gastric bypass patients to 
      promote weight loss: a systematic review and meta-analysis.
PG  - E1332-E1340
LID - 10.1055/a-1214-5822 [doi]
AB  - Background and study aims  Transoral outlet reduction (TORe) is an endoscopic 
      procedure used in patients with weight gain post Roux-en-Y gastric bypass (RYGB). 
      We performed a systematic review and meta-analysis to evaluate the efficacy and 
      safety of TORe with a full-thickness suturing device for treating patients with 
      weight regain after RYGB. Patients and methods  We conducted a comprehensive 
      search of several databases and conference proceedings including PubMed, EMBASE, 
      Google-Scholar, MEDLINE, SCOPUS, and Web of Science databases (earliest inception 
      to March 2020). The primary outcomes assessed were technical success, absolute 
      weight loss (AWL) and percent of total weight loss (% TWL) at 3, 6, and 12 months 
      after the procedure. The secondary outcomes assessed were pooled rate of adverse 
      events (AEs), adverse event subtypes and association of size of gastrojejunal 
      anastomosis (GJA) and percent TWL. Results  Thirteen studies on 850 patients were 
      included. The pooled rate of technical success was 99.89 %. The absolute weight 
      loss (kg) at 3, 6, and 12 months was 6.14, 10.15, and 7.14, respectively. The 
      percent TWL at 3, 6, and 12 months was 6.69, 11.34, and 8.55, respectively. The 
      pooled rate of AE was 11.4 % with abdominal pain being the most common adverse 
      event. The correlation coefficient (r) was -0.11 between post TORe GJA size and 
      weight loss at 12 months. Conclusion  TORe is an endoscopic procedure that is 
      safe and technically feasible for post RYGB with weight gain.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution-NonDerivative-NonCommercial License, 
      permitting copying and reproduction so long as the original work is given 
      appropriate credit. Contents may not be used for commecial purposes, or adapted, 
      remixed, transformed or built upon. 
      (https://creativecommons.org/licenses/by-nc-nd/4.0/).
FAU - Dhindsa, Banreet Singh
AU  - Dhindsa BS
AD  - Department of Internal Medicine, University of Nebraska Medical Center, Las 
      Vegas, Nevada, United States.
FAU - Saghir, Syed Mohsin
AU  - Saghir SM
AD  - Department of Internal Medicine, University of Nebraska Medical Center, Las 
      Vegas, Nevada, United States.
FAU - Naga, Yassin
AU  - Naga Y
AD  - Department of Internal Medicine, University of Nebraska Medical Center, Las 
      Vegas, Nevada, United States.
FAU - Dhaliwal, Amaninder
AU  - Dhaliwal A
AD  - Division of Gastroenterology and Hepatology, University of Nebraska Medical 
      Center, Las Vegas, Nevada, United States.
FAU - Ramai, Dayl
AU  - Ramai D
AD  - Department of Internal Medicine, The Brooklyn Hospital Center, Brooklyn, New 
      York, United States.
FAU - Cross, Chad
AU  - Cross C
AD  - Department of Biostatistics and Epidemiology, University of Nevada Las Vegas, Las 
      Vegas, Nevada, United States.
FAU - Singh, Shailender
AU  - Singh S
AD  - Division of Gastroenterology and Hepatology, University of Nebraska Medical 
      Center, Las Vegas, Nevada, United States.
FAU - Bhat, Ishfaq
AU  - Bhat I
AD  - Division of Gastroenterology and Hepatology, University of Nebraska Medical 
      Center, Las Vegas, Nevada, United States.
FAU - Adler, Douglas G
AU  - Adler DG
AD  - Gastroenterology and Hepatology, University of Utah School of Medicine, Huntsman 
      Cancer Center, Salt Lake City, Utah.
LA  - eng
PT  - Journal Article
DEP - 20200922
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC7511267
COIS- Competing interests The authors declare that they have no conflict of interest.
EDAT- 2020/10/06 06:00
MHDA- 2020/10/06 06:01
PMCR- 2020/10/01
CRDT- 2020/10/05 06:22
PHST- 2020/04/08 00:00 [received]
PHST- 2020/05/22 00:00 [accepted]
PHST- 2020/10/05 06:22 [entrez]
PHST- 2020/10/06 06:00 [pubmed]
PHST- 2020/10/06 06:01 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - 10.1055/a-1214-5822 [doi]
PST - ppublish
SO  - Endosc Int Open. 2020 Oct;8(10):E1332-E1340. doi: 10.1055/a-1214-5822. Epub 2020 
      Sep 22.