PMID- 33015599
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201006
IS  - 2589-9090 (Electronic)
IS  - 2589-9090 (Linking)
VI  - 3
DP  - 2020
TI  - cDC1 are required for the initiation of collagen-induced arthritis.
PG  - 100066
LID - 10.1016/j.jtauto.2020.100066 [doi]
LID - 100066
AB  - Rheumatoid arthritis (RA) is chronic autoimmune disease which etiology remains 
      unknown. Several cell types have been described to potentiate/aggravate the 
      arthritic process however the initiating event in synovial inflammation is still 
      elusive. Dendritic cells (DCs) are essential for the initiation of primary immune 
      responses and thus we hypothesized that these cells might be crucial for RA 
      induction. DCs are a heterogeneous population of cells comprising different 
      subsets with distinct phenotype and function. Here we investigated which DC 
      subset(s) is/are crucial for the initiation of the arthritic process. We have 
      previously demonstrated that Flt3-/- mice, with reduced DCs, were protected from 
      collagen induced arthritis (CIA). Here we have shown that GM-CSF derived DCs in 
      Flt3L-/- mice are functional but not sufficient to induce arthritis. Batf3(-/-) 
      mice lacking both CD103(+) and CD8alpha(+) cDC1 were resistant to collagen induced 
      arthritis (CIA), demonstrating that this DC subset is crucial for arthritis 
      development. CEP-701 (a Flt3L inhibitor) treatment prevented CIA induction, and 
      reduced dramatically the numbers CD103(+) cDC1s present in the lymph nodes and 
      synovium. Hence this study identified cDC1 as the main subset orchestrating the 
      initiation of cell-mediated immunity in arthritis.
CI  - (c) 2020 Published by Elsevier B.V.
FAU - Ramos, Maria Ines
AU  - Ramos MI
AD  - Department of Clinical Immunology and Rheumatology.
AD  - Department of Experimental Immunology, Academic Medical Center/University of 
      Amsterdam, Amsterdam, the Netherlands.
FAU - Garcia, Samuel
AU  - Garcia S
AD  - Department of Clinical Immunology and Rheumatology.
AD  - Department of Experimental Immunology, Academic Medical Center/University of 
      Amsterdam, Amsterdam, the Netherlands.
FAU - Helder, Boy
AU  - Helder B
AD  - Department of Clinical Immunology and Rheumatology.
AD  - Department of Experimental Immunology, Academic Medical Center/University of 
      Amsterdam, Amsterdam, the Netherlands.
FAU - Aarrass, Saida
AU  - Aarrass S
AD  - Department of Clinical Immunology and Rheumatology.
AD  - Department of Experimental Immunology, Academic Medical Center/University of 
      Amsterdam, Amsterdam, the Netherlands.
FAU - Reedquist, Kris A
AU  - Reedquist KA
AD  - Department of Clinical Immunology and Rheumatology.
AD  - Department of Experimental Immunology, Academic Medical Center/University of 
      Amsterdam, Amsterdam, the Netherlands.
FAU - Jacobsen, Sten E
AU  - Jacobsen SE
AD  - Haematopoietic Stem Cell Laboratory and MRC Molecular Haematology Unit, 
      Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University 
      of Oxford, Oxford, UK.
FAU - Tak, Paul Peter
AU  - Tak PP
AD  - Department of Clinical Immunology and Rheumatology.
FAU - Lebre, Maria Cristina
AU  - Lebre MC
AD  - Department of Clinical Immunology and Rheumatology.
AD  - Department of Experimental Immunology, Academic Medical Center/University of 
      Amsterdam, Amsterdam, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20200916
PL  - Netherlands
TA  - J Transl Autoimmun
JT  - Journal of translational autoimmunity
JID - 101759413
PMC - PMC7522802
OTO - NOTNLM
OT  - Autoimmunity
OT  - Dendritic cells
OT  - Inflammation
OT  - cDC1
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2020/10/06 06:00
MHDA- 2020/10/06 06:01
PMCR- 2020/09/16
CRDT- 2020/10/05 06:24
PHST- 2020/07/09 00:00 [received]
PHST- 2020/09/03 00:00 [revised]
PHST- 2020/09/03 00:00 [accepted]
PHST- 2020/10/05 06:24 [entrez]
PHST- 2020/10/06 06:00 [pubmed]
PHST- 2020/10/06 06:01 [medline]
PHST- 2020/09/16 00:00 [pmc-release]
AID - S2589-9090(20)30033-2 [pii]
AID - 100066 [pii]
AID - 10.1016/j.jtauto.2020.100066 [doi]
PST - epublish
SO  - J Transl Autoimmun. 2020 Sep 16;3:100066. doi: 10.1016/j.jtauto.2020.100066. 
      eCollection 2020.