PMID- 33015956
OWN - NLM
STAT- MEDLINE
DCOM- 20210713
LR  - 20210713
IS  - 1932-8494 (Electronic)
IS  - 1932-8486 (Linking)
VI  - 304
IP  - 5
DP  - 2021 May
TI  - Changes in hippocampal capillaries in transgenic type 2 diabetic mice: A 
      stereological investigation.
PG  - 1071-1083
LID - 10.1002/ar.24525 [doi]
AB  - The cognitive dysfunction associated with type 2 diabetes mellitus (T2DM) has 
      been widely studied, and many structures in the hippocampus, such as neurons and 
      synapses, have been shown to play a crucial role in the cognitive decline. 
      However, the mechanism of these changes remains unknown. To further explore this 
      issue, we investigated the changes in the blood supply of the hippocampus in 
      transgenic T2DM mice. In the current study, histochemistry, immunohistochemistry, 
      and unbiased stereological methods were utilized to research the effects of T2DM 
      on hippocampal capillaries of transgenic db/db mice. Twenty (Lepr(db) ) mut/mut 
      mice and twenty (Lepr(db) ) wt/wt mice were used in this study. The learning and 
      memory ability was appraised by Morris water maze test.
CI  - (c) 2021 American Association for Anatomy.
FAU - Zhao, Yuanyu
AU  - Zhao Y
AD  - Department of Pathology, Sichuan Science City Hospital, Mianyang, Sichuan 
      Province, China.
FAU - Liu, Jin
AU  - Liu J
AD  - Laboratory of Electron Microscopy, North Sichuan Medical College, Nanchong, 
      Sichuan Province, China.
FAU - Li, Jing
AU  - Li J
AD  - Laboratory of Electron Microscopy, North Sichuan Medical College, Nanchong, 
      Sichuan Province, China.
FAU - Zhao, Feng
AU  - Zhao F
AD  - Laboratory of Electron Microscopy, North Sichuan Medical College, Nanchong, 
      Sichuan Province, China.
FAU - Du, Shijuan
AU  - Du S
AUID- ORCID: 0000-0001-5443-2069
AD  - Department of Pathology, Sichuan Science City Hospital, Mianyang, Sichuan 
      Province, China.
FAU - Wang, Yunzi
AU  - Wang Y
AD  - Department of Pathology, Sichuan Science City Hospital, Mianyang, Sichuan 
      Province, China.
FAU - Li, Juan
AU  - Li J
AD  - Department of Pathology, Sichuan Science City Hospital, Mianyang, Sichuan 
      Province, China.
FAU - Yang, Lijun
AU  - Yang L
AD  - Department of Pathology, Sichuan Science City Hospital, Mianyang, Sichuan 
      Province, China.
FAU - Du, Jiang
AU  - Du J
AD  - Department of General Surgery, Sichuan Science City Hospital, Mianyang, Sichuan 
      Province, China.
FAU - Tang, Yong
AU  - Tang Y
AD  - Department of Histology and Embryology, Chongqing Medical University, Chongqing, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201116
PL  - United States
TA  - Anat Rec (Hoboken)
JT  - Anatomical record (Hoboken, N.J. : 2007)
JID - 101292775
SB  - IM
MH  - Animals
MH  - Cell Count
MH  - Diabetes Mellitus, Type 2/*pathology
MH  - Female
MH  - Hippocampus/*blood supply/pathology
MH  - Male
MH  - Maze Learning/*physiology
MH  - Mice
MH  - Mice, Transgenic
MH  - Neurons/*pathology
MH  - Organ Size/physiology
MH  - Spatial Memory/*physiology
OTO - NOTNLM
OT  - capillary
OT  - hippocampu
OT  - stereology
OT  - type 2 diabetes
EDAT- 2020/10/06 06:00
MHDA- 2021/07/14 06:00
CRDT- 2020/10/05 06:27
PHST- 2020/06/30 00:00 [revised]
PHST- 2020/05/01 00:00 [received]
PHST- 2020/07/19 00:00 [accepted]
PHST- 2020/10/06 06:00 [pubmed]
PHST- 2021/07/14 06:00 [medline]
PHST- 2020/10/05 06:27 [entrez]
AID - 10.1002/ar.24525 [doi]
PST - ppublish
SO  - Anat Rec (Hoboken). 2021 May;304(5):1071-1083. doi: 10.1002/ar.24525. Epub 2020 
      Nov 16.