PMID- 33016178
OWN - NLM
STAT- MEDLINE
DCOM- 20201221
LR  - 20221207
IS  - 1941-9260 (Electronic)
IS  - 0032-5481 (Linking)
VI  - 132
IP  - 8
DP  - 2020 Nov
TI  - Impact of sodium-glucose cotransporter-2 inhibitors-induced glucosuria in the 
      incidence of urogenital infection on postmenopausal women with diabetes.
PG  - 697-701
LID - 10.1080/00325481.2020.1816360 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) in postmenopausal women is associated 
      with a high incidence of urogenital infections, which negatively impact the 
      quality of life and increase morbidity, mortality, and health-care costs. 
      Glucosuria is a known risk factor for these infections; therefore, it is of 
      interest to determine if increased glucosuria secondary to sodium-glucose 
      cotransporter-2 inhibitors (SGLT2in) impacts the incidence and severity of 
      urogenital infections in postmenopausal women with T2DM. METHODS: The study was 
      conducted at Gaffree Guinle University Hospital on two groups of postmenopausal 
      women with T2DM: with and without SGLT2in therapy (n = 80 in each group). Medical 
      records and laboratory parameters (urinary dipstick test and culture; blood 
      glucose, glycosylated hemoglobin, and creatinine; cervical cytologic study) of 
      all subjects were carefully assessed at baseline and thrice during the 12-month 
      study period. RESULTS: We observed a significant incidence of vulvovaginitis 
      (relative risk [RR], 2.37; 95% confidence interval [CI], 1.10-5.10; P = 0.03) and 
      asymptomatic bacteriuria (RR, 2.47; 95% CI, 1.09-5.60; P = 0.03), but not of 
      urinary tract infections (RR, 2.08; 95% CI, 0.74-5.81; P = 0.16), secondary to 
      SGLT2in therapy. Genital infection was severe enough to warrant treatment 
      discontinuation in 57.89% of patients in group 1. All urinary tract infections 
      were of mild intensity with a good response to antibiotic therapy. CONCLUSION: 
      Glucosuria induced by SGLT2in therapy may lead to a high incidence of urogenital 
      infections in postmenopausal women with T2DM and can be considered a risk factor 
      for these infections.
FAU - Marques, Luiz Paulo Jose
AU  - Marques LPJ
AUID- ORCID: 0000-0003-2235-7257
AD  - Renal Unit of Gaffree and Guinle University Hospital - Department of Medicine, 
      Federal University of Rio de Janeiro State , Rio de Janeiro, Brazil.
FAU - Mendonca, Nayanne Aguiar
AU  - Mendonca NA
AUID- ORCID: 0000-0002-4016-7775
AD  - Renal Unit of Gaffree and Guinle University Hospital - Department of Medicine, 
      Federal University of Rio de Janeiro State , Rio de Janeiro, Brazil.
FAU - Muller, Lucas
AU  - Muller L
AUID- ORCID: 0000-0003-1933-8995
AD  - Renal Unit of Gaffree and Guinle University Hospital - Department of Medicine, 
      Federal University of Rio de Janeiro State , Rio de Janeiro, Brazil.
FAU - Andre, Ana Carolina Pereira Diaz
AU  - Andre ACPD
AUID- ORCID: 0000-0002-6954-7704
AD  - Renal Unit of Gaffree and Guinle University Hospital - Department of Medicine, 
      Federal University of Rio de Janeiro State , Rio de Janeiro, Brazil.
FAU - Madeira, Eugenio Pacelle Queiroz
AU  - Madeira EPQ
AUID- ORCID: 0000-0003-4328-2469
AD  - Renal Unit of Gaffree and Guinle University Hospital - Department of Medicine, 
      Federal University of Rio de Janeiro State , Rio de Janeiro, Brazil.
FAU - Vieira, Lygia Maria Soares Fernandes
AU  - Vieira LMSF
AUID- ORCID: 0000-0003-4167-3642
AD  - Renal Unit of Gaffree and Guinle University Hospital - Department of Medicine, 
      Federal University of Rio de Janeiro State , Rio de Janeiro, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20201005
PL  - England
TA  - Postgrad Med
JT  - Postgraduate medicine
JID - 0401147
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Sodium-Glucose Transporter 2 Inhibitors)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Aged
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Bacteriuria/etiology
MH  - Blood Glucose
MH  - Case-Control Studies
MH  - Creatinine/blood
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Female
MH  - Glycated Hemoglobin
MH  - Glycosuria/*chemically induced/*complications
MH  - Humans
MH  - Incidence
MH  - Longitudinal Studies
MH  - Middle Aged
MH  - *Postmenopause
MH  - Prospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Sodium-Glucose Transporter 2 Inhibitors/*adverse effects/therapeutic use
MH  - Urinary Tract Infections/drug therapy/*etiology
MH  - Vulvovaginitis/etiology
OTO - NOTNLM
OT  - Type 2 diabetes mellitus
OT  - asymptomatic bacteriuria
OT  - sodium-glucose cotransporter 2 inhibitor
OT  - urinary tract infection
OT  - urogenital infection
EDAT- 2020/10/06 06:00
MHDA- 2020/12/22 06:00
CRDT- 2020/10/05 08:40
PHST- 2020/10/06 06:00 [pubmed]
PHST- 2020/12/22 06:00 [medline]
PHST- 2020/10/05 08:40 [entrez]
AID - 10.1080/00325481.2020.1816360 [doi]
PST - ppublish
SO  - Postgrad Med. 2020 Nov;132(8):697-701. doi: 10.1080/00325481.2020.1816360. Epub 
      2020 Oct 5.