PMID- 33016228
OWN - NLM
STAT- MEDLINE
DCOM- 20211124
LR  - 20220426
IS  - 1477-111X (Electronic)
IS  - 0267-6591 (Linking)
VI  - 36
IP  - 7
DP  - 2021 Oct
TI  - Precondition of sevoflurane upregulates TIMP3 expression to alleviate myocardial 
      ischemia/reperfusion injury.
PG  - 717-723
LID - 10.1177/0267659120960306 [doi]
AB  - BACKGROUND: Previous studies have pointed out that sevoflurane (Sef) 
      preconditioning could relieve myocardial ischemia/reperfusion (I/R) injury, but 
      the mechanisms is still unknown. METHODS: C57BL/6 mice model of myocardial I/R 
      injury was established to evaluate the function of Sef. Briefly, Sef was inhaled 
      before I/R operation. The levels of TIMP3, oxidative damage-related factors, and 
      mitogen activated protein kinases (MAPKs) pathway-related factors were measured 
      by qRT-PCR and western blot. Myocardial infarction (MI) area was detected by 
      triphenyl tetrazolium chloride (TTC) staining assay. RESULTS: Sef preconditioning 
      reduced MI area in myocardial I/R injury mice and upregulated TIMP3 expression in 
      myocardial tissues of I/R mice. In addition, downregulation of TIMP3 reversed the 
      alleviating effects of Sef pretreatment on myocardial oxidative damage and 
      inhibited the effect of Sef pretreatment on MAPKs pathway activity. CONCLUSION: 
      Sef preconditioning ameliorated myocardial I/R injury by modulating MAPKs pathway 
      activity via upregulating TIMP3.
FAU - Wang, Fen
AU  - Wang F
AD  - Department of Cardiovascular Medicine, Affiliated Hospital of Jiangnan 
      University, Wuxi, Jiangsu, China.
FAU - Tong, Hua
AU  - Tong H
AUID- ORCID: 0000-0002-2581-6044
AD  - Department of Anesthesiology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China.
LA  - eng
PT  - Journal Article
DEP - 20201004
PL  - England
TA  - Perfusion
JT  - Perfusion
JID - 8700166
RN  - 38LVP0K73A (Sevoflurane)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Myocardial Reperfusion Injury/drug therapy/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sevoflurane/pharmacology
MH  - Signal Transduction
OTO - NOTNLM
OT  - MAPKs pathway
OT  - TIMP3
OT  - ischemia/reperfusion
OT  - myocardial infarction
OT  - sevoflurane
EDAT- 2020/10/06 06:00
MHDA- 2021/11/25 06:00
CRDT- 2020/10/05 08:41
PHST- 2020/10/06 06:00 [pubmed]
PHST- 2021/11/25 06:00 [medline]
PHST- 2020/10/05 08:41 [entrez]
AID - 10.1177/0267659120960306 [doi]
PST - ppublish
SO  - Perfusion. 2021 Oct;36(7):717-723. doi: 10.1177/0267659120960306. Epub 2020 Oct 
      4.