PMID- 33016995
OWN - NLM
STAT- MEDLINE
DCOM- 20210330
LR  - 20210330
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 40
IP  - 10
DP  - 2020 Oct 30
TI  - The association of interieukin-6 polymorphism (rs1800795) with microvascular 
      complications in Type 2 diabetes mellitus.
LID - 10.1042/BSR20201105 [doi]
LID - BSR20201105
AB  - OBJECTIVES: To evaluate the effects of the single-nucleotide polymorphism (SNP) 
      rs1800795 in interieukin-6 (IL-6) gene on diabetic microvascular complications of 
      Type 2 diabetes mellitus (T2DM), using statistical meta-analysis. METHODS: 
      Literature pertaining to the relationship between the SNP rs1800795 and 
      microvascular complications of T2DM including diabetic retinopathy, diabetic 
      nephropathy, diabetic neuropathy and foot disease was retrieved from PubMed, Web 
      of Science Knowledge and SinoMed databases. Original information was analyzed 
      using Stata 12.0, including meta-analysis statistics, test for heterogeneity, 
      evaluation of publication bias and sensitivity. Subgroup analysis was conducted 
      to assess the effect of specific factors on the corresponding results. RESULTS: 
      In total, 14 eligible articles were obtained. The SNP rs1800795 in IL-6 gene is 
      not correlated with risk of microvascular complications in T2DM. Among the 
      original literature, a genetic model (OR = 1.071, 95% CI: 0.681-1.685, P=0.767), 
      an allelic genetic model (OR = 1.010, 95% CI: 0.959-1.063, P=0.703), a 
      heterozygote genetic model (OR = 1.107, 95% CI: 0.916-1.339, P=0.292), a dominant 
      genetic model (OR = 1.108, 95% CI: 0.885-1.387, P=0.372), and a recessive genetic 
      model (OR = 0.978, 95% CI: 0.646-1.478, P=0.917) were included respectively. In 
      the subgroup analysis by types of diabetic microvascular complications, we found 
      no correlation between the SNP rs1000795 polymorphism and complications of T2DM 
      in either the homozygote genetic model or the allelic genetic model (P<0.05). 
      CONCLUSION: Our results demonstrate that rs1800795 polymorphism in IL-6 gene is 
      not correlated with the susceptibility of microvascular complications of T2DM.
CI  - (c) 2020 The Author(s).
FAU - Cui, Jieyuan
AU  - Cui J
AD  - Department of Nephrology and Immunology, Children's Hospital of Hebei Province, 
      Shijiazhuang 050031, China.
AD  - Department of Pediatric, The Third Hospital of Hebei Medical University, 
      Shijiazhuang 050051, China.
FAU - Zhang, Xiaolin
AU  - Zhang X
AD  - Department of Epidemiology and statistics, School of Public Health, Hebei Medical 
      University, Hebei Province Key Laboratory of Environment and Human Health, 
      Shijiazhuang 050020, China.
FAU - Guo, Cheng
AU  - Guo C
AD  - Department of Pediatric, The Third Hospital of Hebei Medical University, 
      Shijiazhuang 050051, China.
FAU - Zhang, Lin
AU  - Zhang L
AD  - Department of Pediatric, The Third Hospital of Hebei Medical University, 
      Shijiazhuang 050051, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/diagnosis/epidemiology/*genetics
MH  - Diabetic Angiopathies/diagnosis/epidemiology/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-6/*genetics
MH  - Male
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Assessment
MH  - Risk Factors
PMC - PMC7569201
OTO - NOTNLM
OT  - Diabetic microvascular complications
OT  - Gene polymorphism
OT  - Interleukin-6 gene
OT  - Type 2 diabetes mellitus
OT  - rs1800795
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2020/10/06 06:00
MHDA- 2021/03/31 06:00
PMCR- 2020/10/16
CRDT- 2020/10/05 12:09
PHST- 2020/05/19 00:00 [received]
PHST- 2020/09/23 00:00 [revised]
PHST- 2020/10/05 00:00 [accepted]
PHST- 2020/10/06 06:00 [pubmed]
PHST- 2021/03/31 06:00 [medline]
PHST- 2020/10/05 12:09 [entrez]
PHST- 2020/10/16 00:00 [pmc-release]
AID - 226582 [pii]
AID - BSR20201105 [pii]
AID - 10.1042/BSR20201105 [doi]
PST - ppublish
SO  - Biosci Rep. 2020 Oct 30;40(10):BSR20201105. doi: 10.1042/BSR20201105.