PMID- 33018790
OWN - NLM
STAT- MEDLINE
DCOM- 20201023
LR  - 20201023
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2020
DP  - 2020 Jul
TI  - Evaluation of Frequency-Dependent Effects of Deep Brain Stimulation in a 
      Cortex-Basal Ganglia-Thalamus Network Model of Parkinson's Disease().
PG  - 3638-3641
LID - 10.1109/EMBC44109.2020.9176570 [doi]
AB  - Parkinson's disease (PD) is a chronic neurodegenerative disease whose motor 
      symptoms are accompanied by an exaggerated power in the alpha-beta (7-35Hz) band 
      and an increased synchronization of neurons encompassing the cortex-basal 
      ganglia-thalamus network. Currently, deep brain stimulation (DBS) is used as an 
      effective therapy for reducing the excessive power and synchrony observed in 
      brain circuits, thereby ameliorating the PD symptoms. In the present study, we 
      used a biologically plausible computational model of cortex-basal 
      ganglia-thalamus network, which represents both healthy and PD conditions, to 
      systematically investigate the effects of DBS frequency on the model outputs. DBS 
      was applied to the subthalamic nucleus (STN) at different stimulation frequencies 
      (40Hz to 300Hz). Spike train variability and spectral power in the 7-35Hz band 
      were measured from the several nuclei represented in the model. In addition, the 
      magnitude squared coherence between the nuclei was assessed. An increased DBS 
      frequency tended to produce interspike intervals (ISIs) with higher variability 
      as compared to PD condition. Also, DBS significantly reduced the alpha-beta power 
      for almost all brain nuclei. The median of the magnitude-squared coherence matrix 
      (which is a metric of global network synchronization) decreased significantly 
      with the increase of DBS frequency.
FAU - Romano, Marcelo R
AU  - Romano MR
FAU - Moioli, Renan C
AU  - Moioli RC
FAU - Elias, Leonardo A
AU  - Elias LA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
SB  - IM
MH  - Basal Ganglia
MH  - *Deep Brain Stimulation
MH  - Humans
MH  - *Neurodegenerative Diseases
MH  - *Parkinson Disease/therapy
MH  - Thalamus
EDAT- 2020/10/07 06:00
MHDA- 2020/10/24 06:00
CRDT- 2020/10/06 01:04
PHST- 2020/10/06 01:04 [entrez]
PHST- 2020/10/07 06:00 [pubmed]
PHST- 2020/10/24 06:00 [medline]
AID - 10.1109/EMBC44109.2020.9176570 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2020 Jul;2020:3638-3641. doi: 
      10.1109/EMBC44109.2020.9176570.