PMID- 3301971
OWN - NLM
STAT- MEDLINE
DCOM- 19870831
LR  - 20201209
IS  - 0342-4642 (Print)
IS  - 0342-4642 (Linking)
VI  - 13
IP  - 4
DP  - 1987
TI  - Thoracic duct lymph and PEEP studies in anaesthetized dogs. II. Effect of a 
      thoracic duct fistula on the development of a hyponcotic-hydrostatic pulmonary 
      oedema.
PG  - 278-83
AB  - PEEP impedes thoracic duct drainage (LF). This can be counteracted by a thoracic 
      duct fistula. Consequently, lung oedema (LOE) should develop during PEEP more 
      slowly with LF at atmospheric pressure (LFAP) than with LF against jugular venous 
      pressure (LFJVP). In 12 anaesthetized dogs LOE was produced by Ringer's solution 
      i.v. (2.5 ml/min per kg) for 6 h during PEEP (10 mmHg) with either LFAP or LFJVP. 
      Ringer's + PEEP greatly increased aortic, pulmonary artery and wedge pressures, 
      JVP, and cardiac output. Colloid osmotic pressures in plasma and lymph were 
      drastically reduced, pulmonary effective filtration pressure (EFP) rose by about 
      20 mmHg. LFJVP increased 7-fold, LFAP about 19-fold, the respective loss of 
      plasma proteins was 1.83 and 1.06 g/kg during 6 h. Thermal-dye extravascular lung 
      water showed an increment of 68 with LFJVP versus 43 microliter/h/g per mmHg with 
      LFAP. Final lung water content was at any delta EFP (12.8-31.9 mmHg) lower with 
      LFAP than with LFJVP amounting 512 with LFJVP versus 377 microliters/g/per mmHg 
      with LFAP. LFAP decreased the development of LOE during PEEP by bypassing the 
      PEEP-induced high JVP and thus facilitating the removal of interstitial fluid. It 
      is hypothesized that a thoracic duct fistula might aid the treatment of patients 
      with LOE due to ARDS and therefore requiring high levels of PEEP.
FAU - Haider, M
AU  - Haider M
FAU - Schad, H
AU  - Schad H
FAU - Mendler, N
AU  - Mendler N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Animals
MH  - Dogs
MH  - Drainage
MH  - Female
MH  - Hemodynamics
MH  - Humans
MH  - Lymph/*physiology
MH  - Male
MH  - Positive-Pressure Respiration/*adverse effects
MH  - Pulmonary Edema/*etiology/prevention & control
MH  - Respiratory Distress Syndrome/therapy
MH  - Thoracic Duct/*physiopathology/surgery
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.1007/BF00265118 [doi]
PST - ppublish
SO  - Intensive Care Med. 1987;13(4):278-83. doi: 10.1007/BF00265118.