PMID- 33020370
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201101
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Linking)
VI  - 7
IP  - 10
DP  - 2020 Oct 4
TI  - Successful Hematopoietic Stem Cell Transplantation from a Matched Related Donor 
      with Beta-Thalassemia Minor for Severe Aplastic Anemia.
LID - E162 [pii]
LID - 10.3390/children7100162 [doi]
AB  - The first-line treatment for severe aplastic anemia (SAA) patients is 
      hematopoietic stem cell transplantation (HSCT), with full-matched related donors 
      considered the most suitable. We report a case of SAA in which the patient 
      successfully underwent HSCT from a donor with beta-thalassemia minor. The patient in 
      this case underwent HSCT from a human leukocyte antigen (HLA)-matched younger 
      brother with beta-thalassemia minor. A 7-year-old girl was referred to our facility 
      following a 6-month history of easy bruising and pallor. Laboratory examinations 
      showed pancytopenia and hypocellular bone marrow with cellularity of <5%. She was 
      diagnosed with acquired SAA, and HLA typing of her family members was performed. 
      Her younger brother was an HLA-matched sibling but had beta-thalassemia minor. Since 
      his hemoglobin levels were maintained at 10-11 d/dL, he was considered a suitable 
      HSCT donor. The conditioning regimen included fludarabine, cyclophosphamide, and 
      anti-thymocyte globulin. The CD34+ and CD3+ cell counts were 6.6 x 10(6)/kg and 
      0.48 x 10(8)/kg, respectively. White blood cell engraftment was evident on day 
      +11. Regimen-associated toxicities, such as anorexia and enteritis, were mild; no 
      infections occurred, and no symptoms of acute graft-versus-host disease (GVHD) 
      were observed. The 30-day follow-up bone marrow examination revealed 
      normocellular marrow with 80%-90% cellularity. Acute or chronic GVHD has not been 
      reported, and good performance status has been observed throughout the 5 years 
      after HSCT. beta-thalassemia minor patients can be considered as bone marrow donors 
      for SAA patients.
FAU - Jung, Mi Young
AU  - Jung MY
AD  - Department of Pediatrics, Yeungnam University College of Medicine, Daegu 42415, 
      Korea.
FAU - Lim, Young Tae
AU  - Lim YT
AD  - Department of Pediatrics, Yeungnam University College of Medicine, Daegu 42415, 
      Korea.
FAU - Lim, Hyunji
AU  - Lim H
AD  - Department of Pediatrics, Yeungnam University College of Medicine, Daegu 42415, 
      Korea.
FAU - Hah, Jeong Ok
AU  - Hah JO
AD  - Department of Pediatrics, Daegu Fatima Hospital, Daegu 41199, Korea.
FAU - Lee, Jae Min
AU  - Lee JM
AUID- ORCID: 0000-0001-6822-1051
AD  - Department of Pediatrics, Yeungnam University College of Medicine, Daegu 42415, 
      Korea.
LA  - eng
GR  - 220A480014/Yeungnam University/
PT  - Case Reports
DEP - 20201004
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC7599690
OTO - NOTNLM
OT  - aplastic anemia
OT  - beta-thalassemia
OT  - hematopoietic stem cell transplantation
OT  - thalassemia minor
EDAT- 2020/10/07 06:00
MHDA- 2020/10/07 06:01
CRDT- 2020/10/06 05:27
PHST- 2020/09/07 00:00 [received]
PHST- 2020/09/28 00:00 [revised]
PHST- 2020/09/30 00:00 [accepted]
PHST- 2020/10/06 05:27 [entrez]
PHST- 2020/10/07 06:00 [pubmed]
PHST- 2020/10/07 06:01 [medline]
AID - children7100162 [pii]
AID - 10.3390/children7100162 [doi]
PST - epublish
SO  - Children (Basel). 2020 Oct 4;7(10):E162. doi: 10.3390/children7100162.