PMID- 33020379
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201103
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 10
IP  - 10
DP  - 2020 Oct 4
TI  - Metformin Enhances Excitatory Synaptic Transmission onto Hippocampal CA1 
      Pyramidal Neurons.
LID - 10.3390/brainsci10100706 [doi]
LID - 706
AB  - Metformin (Met) is a first-line drug for type 2 diabetes mellitus (T2DM). 
      Numerous studies have shown that Met exerts beneficial effects on a variety of 
      neurological disorders, including Alzheimer's disease (AD), Parkinson's disease 
      (PD) and Huntington's disease (HD). However, it is still largely unclear how Met 
      acts on neurons. Here, by treating acute hippocampal slices with Met (1 muM and 10 
      muM) and recording synaptic transmission as well as neuronal excitability of CA1 
      pyramidal neurons, we found that Met treatments significantly increased the 
      frequency of miniature excitatory postsynaptic currents (mEPSCs), but not 
      amplitude. Neither frequency nor amplitude of miniature inhibitory postsynaptic 
      currents (mIPSCs) were changed with Met treatments. Analysis of paired-pulse 
      ratios (PPR) demonstrates that enhanced presynaptic glutamate release from 
      terminals innervating CA1 hippocampal pyramidal neurons, while excitability of 
      CA1 pyramidal neurons was not altered. Our results suggest that Met 
      preferentially increases glutamatergic rather than GABAergic transmission in 
      hippocampal CA1, providing a new insight on how Met acts on neurons.
FAU - Chen, Wen-Bing
AU  - Chen WB
AD  - School of Life Sciences, Nanchang University, Nanchang 330031, China.
AD  - Institute of Life Science, Nanchang University, Nanchang 330031, China.
FAU - Chen, Jiang
AU  - Chen J
AD  - School of Life Sciences, Nanchang University, Nanchang 330031, China.
AD  - Institute of Life Science, Nanchang University, Nanchang 330031, China.
FAU - Liu, Zi-Yang
AU  - Liu ZY
AD  - School of Life Sciences, Nanchang University, Nanchang 330031, China.
AD  - Institute of Life Science, Nanchang University, Nanchang 330031, China.
FAU - Luo, Bin
AU  - Luo B
AD  - School of Life Sciences, Nanchang University, Nanchang 330031, China.
AD  - Institute of Life Science, Nanchang University, Nanchang 330031, China.
FAU - Zhou, Tian
AU  - Zhou T
AD  - School of Basic Medical Sciences, Nanchang University, Nanchang 330031, China.
FAU - Fei, Er-Kang
AU  - Fei EK
AUID- ORCID: 0000-0002-3581-9521
AD  - School of Life Sciences, Nanchang University, Nanchang 330031, China.
AD  - Institute of Life Science, Nanchang University, Nanchang 330031, China.
LA  - eng
GR  - 81460215/National Natural Science Foundation of China/
GR  - 31771142/National Natural Science Foundation of China/
GR  - 31860268/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20201004
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC7601223
OTO - NOTNLM
OT  - glutamate release
OT  - hippocampal
OT  - metformin
OT  - neuronal excitability
OT  - pyramidal neurons
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/07 06:00
MHDA- 2020/10/07 06:01
PMCR- 2020/10/01
CRDT- 2020/10/06 05:27
PHST- 2020/08/18 00:00 [received]
PHST- 2020/09/25 00:00 [revised]
PHST- 2020/10/01 00:00 [accepted]
PHST- 2020/10/06 05:27 [entrez]
PHST- 2020/10/07 06:00 [pubmed]
PHST- 2020/10/07 06:01 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - brainsci10100706 [pii]
AID - brainsci-10-00706 [pii]
AID - 10.3390/brainsci10100706 [doi]
PST - epublish
SO  - Brain Sci. 2020 Oct 4;10(10):706. doi: 10.3390/brainsci10100706.