PMID- 33020792
OWN - NLM
STAT- MEDLINE
DCOM- 20211026
LR  - 20211026
IS  - 1460-4752 (Electronic)
IS  - 0265-0568 (Linking)
VI  - 37
IP  - 11
DP  - 2020 Nov 18
TI  - Guided by evolution: from biology oriented synthesis to pseudo natural products.
PG  - 1497-1510
LID - 10.1039/d0np00015a [doi]
AB  - Covering: up to 2020 Natural products (NPs) provide inspiration for the design of 
      biologically active compounds and libraries. In this review, we cover several 
      experimental and in silico approaches, which have been used to simplify NPs and 
      guide NP-based library design. Earlier approaches, like the structural 
      classification of natural products (SCONP) and biology-oriented synthesis (BIOS), 
      focus on the identification of activity determining scaffolds and the synthesis 
      of corresponding compound collections. More recently, NP fragments identified by 
      means of cheminformatic analysis of the Dictionary of Natural Products (DNP) have 
      been combined in unprecedented fashions to yield pseudo natural products (pseudo 
      NPs), which show biological activities unrelated to the guiding NPs. Each 
      approach was also the source of chemical innovation, in which synthetic methods 
      were established for the rapid assembly of NP-inspired compounds and libraries.
FAU - Cremosnik, Gregor S
AU  - Cremosnik GS
AUID- ORCID: 0000-0003-3216-5312
AD  - Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, 
      Otto-Hahn-Strasse 11, 44227 Dortmund, Germany. 
      herbert.waldmann@mpi-dortmund.mpg.de.
FAU - Liu, Jie
AU  - Liu J
AUID- ORCID: 0000-0002-9455-325X
AD  - Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, 
      Otto-Hahn-Strasse 11, 44227 Dortmund, Germany. 
      herbert.waldmann@mpi-dortmund.mpg.de and Faculty of Chemistry and Chemical 
      Biology, TU Dortmund University, 44227 Dortmund, Germany.
FAU - Waldmann, Herbert
AU  - Waldmann H
AUID- ORCID: 0000-0002-9606-7247
AD  - Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, 
      Otto-Hahn-Strasse 11, 44227 Dortmund, Germany. 
      herbert.waldmann@mpi-dortmund.mpg.de and Faculty of Chemistry and Chemical 
      Biology, TU Dortmund University, 44227 Dortmund, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Prod Rep
JT  - Natural product reports
JID - 8502408
RN  - 0 (Biological Products)
SB  - IM
MH  - Biological Products/*chemical synthesis/chemistry/pharmacology
MH  - Computer Simulation
MH  - *Evolution, Chemical
MH  - Molecular Structure
EDAT- 2020/10/07 06:00
MHDA- 2021/10/27 06:00
CRDT- 2020/10/06 05:33
PHST- 2020/10/07 06:00 [pubmed]
PHST- 2021/10/27 06:00 [medline]
PHST- 2020/10/06 05:33 [entrez]
AID - 10.1039/d0np00015a [doi]
PST - ppublish
SO  - Nat Prod Rep. 2020 Nov 18;37(11):1497-1510. doi: 10.1039/d0np00015a.