PMID- 33021876 OWN - NLM STAT- MEDLINE DCOM- 20210818 LR - 20210818 IS - 1502-7708 (Electronic) IS - 0036-5521 (Linking) VI - 55 IP - 11 DP - 2020 Nov TI - Safety and durability of PEG-J: a single-centre experience. PG - 1377-1380 LID - 10.1080/00365521.2020.1829033 [doi] AB - INTRODUCTION: Although percutaneous endoscopic gastrostomy with jejunal extension (PEG-J) is currently indicated in a variety of conditions, limited data are available regarding its safety and the best timing for its replacement. We herein describe a single-centre cohort of patients who underwent PEG-J placement or replacement to assess the short- and long-term safety of the procedure. METHODS: Demographic and procedure-related data regarding all patients undergoing a PEG-J procedure between March 2010 and 2020, either first placement or any replacement, at the Endoscopy Unit of a University Hospital in Northern Italy (IRCCS Policlinico San Matteo, Pavia, Italy), were retrospectively collected. Data were collected until last available follow-up. RESULTS: We included 73 patients (mean age 70 +/- 9.7, 60.3% female) who underwent a PEG-J procedure. Data on a total of 215 procedures were gathered with a median follow up time of 21 months (IQR 9.3-39.5). No immediate adverse events (AEs) were reported. Short-term (within 30 days) AEs, including jejunal extension dislocations, accidental removal, obstruction and kinking occurred in 12 patients (5.6% of the total procedures), whilst long-term AEs (obstruction, tube malfunctions, inner tube dislocation, pyloric ulcer, hypergranulation tissue, wear, buried bumper syndrome and accidental removal) were reported in 40 patients. The risk of developing an AE was not reduced if tube replacement was performed electively. The median duration of the PEG-J before replacement was 12 months (IQR 6-16 months). CONCLUSION: PEG-J placement and replacement are safe procedures. Although PEG-J durability is variable an elective procedure might be indicated to reduce urgent replacements. FAU - Cococcia, Sara AU - Cococcia S AUID- ORCID: 0000-0002-1507-6513 AD - Department of Internal Medicine and Digestive Endoscopy Unit, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy. FAU - Rovedatti, Laura AU - Rovedatti L AUID- ORCID: 0000-0001-6333-7485 AD - Department of Internal Medicine and Digestive Endoscopy Unit, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy. FAU - Lenti, Marco Vincenzo AU - Lenti MV AUID- ORCID: 0000-0002-6654-4911 AD - Department of Internal Medicine and Digestive Endoscopy Unit, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy. FAU - Pozzi, Lodovica AU - Pozzi L AD - Department of Internal Medicine and Digestive Endoscopy Unit, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy. FAU - De Grazia, Federico AU - De Grazia F AD - Department of Internal Medicine and Digestive Endoscopy Unit, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy. FAU - Di Sabatino, Antonio AU - Di Sabatino A AUID- ORCID: 0000-0002-0302-8645 AD - Department of Internal Medicine and Digestive Endoscopy Unit, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy. LA - eng PT - Journal Article DEP - 20201006 PL - England TA - Scand J Gastroenterol JT - Scandinavian journal of gastroenterology JID - 0060105 SB - IM MH - Aged MH - Endoscopy MH - *Enteral Nutrition MH - Female MH - *Gastrostomy/adverse effects MH - Humans MH - Jejunum MH - Male MH - Retrospective Studies OTO - NOTNLM OT - PEG-J OT - adverse event OT - jejunal extension OT - safety OT - tube damage EDAT- 2020/10/07 06:00 MHDA- 2021/08/19 06:00 CRDT- 2020/10/06 17:10 PHST- 2020/10/07 06:00 [pubmed] PHST- 2021/08/19 06:00 [medline] PHST- 2020/10/06 17:10 [entrez] AID - 10.1080/00365521.2020.1829033 [doi] PST - ppublish SO - Scand J Gastroenterol. 2020 Nov;55(11):1377-1380. doi: 10.1080/00365521.2020.1829033. Epub 2020 Oct 6.