PMID- 33022571
OWN - NLM
STAT- MEDLINE
DCOM- 20201218
LR  - 20231214
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 268
IP  - Pt B
DP  - 2021 Jan 1
TI  - Long-term exposure to phenanthrene at environmental-level induces intestinal 
      dysbiosis and disrupted hepatic lipid metabolism in mice.
PG  - 115738
LID - S0269-7491(20)36427-7 [pii]
LID - 10.1016/j.envpol.2020.115738 [doi]
AB  - Phenanthrene (Phe), among the most ubiquitous polycyclic aromatic hydrocarbons 
      (PAHs) existing in nature and foodstuffs, has severe effects on hepatic lipids 
      metabolism. However, the detailed mechanism involved is still unknown. For 
      environmental chemicals can disturb intestinal microbiota, which plays a vital 
      role in lipids metabolism, we hypothesized that oral exposure to Phe may disrupt 
      the intestinal microbiota, leading to the induction of an abnormal inflammatory 
      response and lipid metabolism dysfunction. Herein, male mice were orally exposed 
      to Phe (0.05, 0.5 and 5 mg/kg/2d) for ten weeks and the results showed that long 
      term exposure to Phe induced significant alteration in relative Bacteroidetes, 
      Firmicutes and Proteobacteria abundance in male mice. Histopathological 
      anomalies, and significantly increased hepatic levels of free fatty acid, 
      cholesterol and triglyceride were observed as well. The expression of hepatic 
      proteins linked to lipid metabolism including peroxisome proliferator-activated 
      receptors (PPARs), liver X receptor beta (LXRbeta) and retinoid X receptors (RXRs) were 
      upregulated. The importance of the gut microbiota in Phe-altered lipid metabolism 
      disorder was further confirmed by fecal microbiota transplantation (FMT). FMT 
      intervention boosted microbial diversity and attenuated Phe-induced elevation in 
      liver somatic index and hepatic total lipids levels. These results demonstrated 
      that environmental-level Phe altered the composition of gastrointestinal bacteria 
      and subsequently induced hepatic lipid metabolism disorder. These results would 
      be helpful for understanding the health risk posed by Phe.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Yu, Xiu
AU  - Yu X
AD  - Department of Anesthesiology, Peking University Shenzhen Hospital, Shenzhen, 
      518036, China; Department of Respiratory and Critical Care Medicine, The Second 
      Clinical Medical College (Shenzhen People's Hospital) of Jinan University, 
      Shenzhen Institute of Respiratory Diseases, Shenzhen, China.
FAU - Lv, Kongpeng
AU  - Lv K
AD  - Department of Infectious Disease, The Second Clinical Medical College (Shenzhen 
      People's Hospital), Jinan University, No. 1017 Dongmen North Road, Shenzhen, 
      China.
FAU - Guan, Shuyuan
AU  - Guan S
AD  - Department of Anesthesiology, Peking University Shenzhen Hospital, Shenzhen, 
      518036, China.
FAU - Zhang, Xinyun
AU  - Zhang X
AD  - Department of Anesthesiology, Peking University Shenzhen Hospital, Shenzhen, 
      518036, China.
FAU - Sun, Lingbin
AU  - Sun L
AD  - Department of Anesthesiology, Peking University Shenzhen Hospital, Shenzhen, 
      518036, China; Department of Infectious Disease, The Second Clinical Medical 
      College (Shenzhen People's Hospital), Jinan University, No. 1017 Dongmen North 
      Road, Shenzhen, China. Electronic address: slbaaa@163.com.
LA  - eng
PT  - Journal Article
DEP - 20200928
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Phenanthrenes)
SB  - IM
EIN - Environ Pollut. 2024 Feb 1;342:123124. PMID: 38096606
MH  - Animals
MH  - Dysbiosis/chemically induced
MH  - *Gastrointestinal Microbiome
MH  - Lipid Metabolism
MH  - Liver/metabolism
MH  - Male
MH  - Mice
MH  - *Phenanthrenes/metabolism/toxicity
OTO - NOTNLM
OT  - Gut microbiota
OT  - Hepatic lipid metabolism disorder
OT  - Phenanthrene
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/10/07 06:00
MHDA- 2020/12/19 06:00
CRDT- 2020/10/06 20:16
PHST- 2020/09/14 00:00 [received]
PHST- 2020/09/22 00:00 [revised]
PHST- 2020/09/24 00:00 [accepted]
PHST- 2020/10/07 06:00 [pubmed]
PHST- 2020/12/19 06:00 [medline]
PHST- 2020/10/06 20:16 [entrez]
AID - S0269-7491(20)36427-7 [pii]
AID - 10.1016/j.envpol.2020.115738 [doi]
PST - ppublish
SO  - Environ Pollut. 2021 Jan 1;268(Pt B):115738. doi: 10.1016/j.envpol.2020.115738. 
      Epub 2020 Sep 28.