PMID- 33023084
OWN - NLM
STAT- MEDLINE
DCOM- 20210318
LR  - 20210318
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 25
IP  - 19
DP  - 2020 Oct 2
TI  - Design of Organoiron Dendrimers Containing Paracetamol for Enhanced Antibacterial 
      Efficacy.
LID - 10.3390/molecules25194514 [doi]
LID - 4514
AB  - Paracetamol (acetaminophen) is a common painkiller and antipyretic drug used 
      globally. Attachment of paracetamol to a series of organoiron dendrimers was 
      successfully synthesized. The aim of this study is to combine the benefits of the 
      presence of these redox-active organoiron dendrimers, their antimicrobial 
      activities against some human pathogenic Gram-positive, and the therapeutic 
      characteristics of paracetamol. The antimicrobial activity of these dendrimers 
      was investigated and tested with a minimum inhibitory concentration and this has 
      been reported. Some of these newly synthesized dendrimers exhibited the highest 
      inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA), 
      vancomycin-resistant Enterococcus faecium (VRE), and Staphylococcus warneri 
      compared to reference drugs. The results of this study indicate that the 
      antimicrobial efficacy of the dendrimers is dependent on the size of the 
      redox-active organoiron dendrimer and its terminal functionalities. The best 
      result has been recorded for the fourth-generation dendrimer 11, which attached 
      to 48 paracetamol end groups and has 90 units composed of the 
      eta(6)-aryl-eta(5)-cyclopentadienyliron (II) complex. This dendrimer presented 
      inhibition of 50% of the growth (IC(50)) of 0.52 muM for MRSA, 1.02 muM for VRE, 
      and 0.73 muM for Staphylococcus warneri. The structures of the dendrimers were 
      characterized by elemental analysis, Fourier transform infrared (FT-IR), nuclear 
      magnetic resonance ((1)H-NMR), and (13)C-NMR spectroscopic techniques. In 
      addition, all synthesized dendrimers displayed good thermal stability in the 
      range of 300-350  degrees C following the degradation of the cationic iron moieties which 
      occurred around 200  degrees C.
FAU - Abd-El-Aziz, Alaa S
AU  - Abd-El-Aziz AS
AD  - Department of Chemistry, University of Prince Edward Island, 550 University 
      Avenue, Charlottetown, PE C1A 4P3, Canada.
FAU - El-Ghezlani, Ebtehal G
AU  - El-Ghezlani EG
AD  - Department of Chemistry, University of Prince Edward Island, 550 University 
      Avenue, Charlottetown, PE C1A 4P3, Canada.
FAU - Abdelghani, Amani A
AU  - Abdelghani AA
AD  - Department of Chemistry, University of Prince Edward Island, 550 University 
      Avenue, Charlottetown, PE C1A 4P3, Canada.
LA  - eng
PT  - Journal Article
DEP - 20201002
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Dendrimers)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/*pharmacology
MH  - Anti-Bacterial Agents/*pharmacology
MH  - Bacteria/drug effects
MH  - Dendrimers/*chemical synthesis/chemistry
MH  - Electrochemistry
MH  - Inhibitory Concentration 50
MH  - Microbial Sensitivity Tests
MH  - Oxidation-Reduction
MH  - Thermogravimetry
PMC - PMC7583835
OTO - NOTNLM
OT  - MRSA
OT  - SEM
OT  - VRE
OT  - dendrimer
OT  - organoiron
OT  - paracetamol
OT  - redox-active
OT  - staphylococcus warneri
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/08 06:00
MHDA- 2021/03/19 06:00
PMCR- 2020/10/02
CRDT- 2020/10/07 01:01
PHST- 2020/09/08 00:00 [received]
PHST- 2020/09/28 00:00 [revised]
PHST- 2020/09/28 00:00 [accepted]
PHST- 2020/10/07 01:01 [entrez]
PHST- 2020/10/08 06:00 [pubmed]
PHST- 2021/03/19 06:00 [medline]
PHST- 2020/10/02 00:00 [pmc-release]
AID - molecules25194514 [pii]
AID - molecules-25-04514 [pii]
AID - 10.3390/molecules25194514 [doi]
PST - epublish
SO  - Molecules. 2020 Oct 2;25(19):4514. doi: 10.3390/molecules25194514.