PMID- 33023259
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201207
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 10
IP  - 4
DP  - 2020 Oct 2
TI  - The Genetics of Spondyloarthritis.
LID - 10.3390/jpm10040151 [doi]
LID - 151
AB  - The term spondyloarthritis (SpA) encompasses a group of chronic inflammatory 
      diseases with common features in terms of clinical presentation and genetic 
      predisposition. SpA is characterized by inflammation of the spine and peripheral 
      joints, and is also be associated with extra-articular inflammatory 
      manifestations such as psoriasis, uveitis, or inflammatory bowel disease (IBD). 
      The etiology of SpA is not completely understood, but it is known to have a 
      strong genetic component dominated by the human leukocyte antigen (HLA)-B27. In 
      the last few years, our understanding of genetic susceptibility to SpA, 
      particularly ankylosing spondylitis (AS), has greatly improved thanks to the 
      findings derived from powered genome-wide association studies (GWAS) based on 
      single nucleotide polymorphism (SNP) arrays. These studies have identified many 
      candidate genes, therefore providing new potential directions in the exploration 
      of disease mechanisms, especially with regard to the key role of the immune 
      system in the pathogenesis of SpA. SpA is a complex disease where genetic 
      variability, environmental factors, and random events interact to trigger 
      pathological pathways. The aim of this review is to summarize current findings on 
      the genetics of SpA, some of which might help to study new treatment approaches.
FAU - Diaz-Pena, Roberto
AU  - Diaz-Pena R
AUID- ORCID: 0000-0002-0114-2292
AD  - Faculty of Health Sciences, Universidad Autonoma de Chile, Talca 3460000, Chile.
FAU - Castro-Santos, Patricia
AU  - Castro-Santos P
AD  - Inmunologia, Centro de Investigaciones Biomedicas (CINBIO), Universidad de Vigo, 
      36310 Vigo, Spain.
FAU - Duran, Josefina
AU  - Duran J
AUID- ORCID: 0000-0001-7376-7729
AD  - Department of Rheumatology, School of Medicine, Pontificia Universidad Catolica 
      de Chile, Santiago 7690000, Chile.
FAU - Santiago, Catalina
AU  - Santiago C
AD  - Faculty of Sport Sciences, European University of Madrid, 28670 Madrid, Spain.
FAU - Lucia, Alejandro
AU  - Lucia A
AD  - Faculty of Sport Sciences, European University of Madrid, 28670 Madrid, Spain.
AD  - Research Institute Hospital 12 de Octubre ('imas12'), 28041 Madrid, Spain.
LA  - eng
GR  - 11130198/Fondo Nacional de Desarrollo Cientifico y Tecnologico/
PT  - Journal Article
PT  - Review
DEP - 20201002
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC7711559
OTO - NOTNLM
OT  - ERAP1
OT  - HLA-B27
OT  - KIR
OT  - ankylosing spondylitis
OT  - ethnic group
OT  - genetics
OT  - genome-wide association studies
OT  - polymorphism
OT  - spondyloarthritis
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/08 06:00
MHDA- 2020/10/08 06:01
PMCR- 2020/10/02
CRDT- 2020/10/07 01:02
PHST- 2020/08/06 00:00 [received]
PHST- 2020/09/17 00:00 [revised]
PHST- 2020/09/24 00:00 [accepted]
PHST- 2020/10/07 01:02 [entrez]
PHST- 2020/10/08 06:00 [pubmed]
PHST- 2020/10/08 06:01 [medline]
PHST- 2020/10/02 00:00 [pmc-release]
AID - jpm10040151 [pii]
AID - jpm-10-00151 [pii]
AID - 10.3390/jpm10040151 [doi]
PST - epublish
SO  - J Pers Med. 2020 Oct 2;10(4):151. doi: 10.3390/jpm10040151.