PMID- 33024729
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201009
IS  - 2287-2892 (Print)
IS  - 2288-2561 (Electronic)
IS  - 2287-2892 (Linking)
VI  - 9
IP  - 3
DP  - 2020 Sep
TI  - Are Persistent Organic Pollutants Linked to Lipid Abnormalities, Atherosclerosis 
      and Cardiovascular Disease? A Review.
PG  - 334-348
LID - 10.12997/jla.2020.9.3.334 [doi]
AB  - The term persistent organic pollutants (POPs) denotes chemicals with known or 
      suspected adverse health effects in animals or humans and with chemical 
      properties that make them accumulate in the environment, including animals or 
      humans. Lipid-soluble POPs, like dioxins, polychlorinated biphenyls (PCBs) and 
      organochlorine pesticides are transported by lipoproteins and accumulate in 
      adipose tissue. High levels of these compounds in the circulation have been 
      associated with elevated cholesterol and triglycerides in cross-sectional studies 
      and with an increase in mainly low-density lipoprotein cholesterol in a 
      longitudinal study. Also, non-lipid-soluble POPs, such as perfluoroalkyl 
      substances (PFASs) compounds have been associated with increased total 
      cholesterol levels. Carotid artery atherosclerosis has been related to elevated 
      levels of mainly highly chlorinated PCBs and to highly fluorinated PFASs, but in 
      this case only in women. Both cross-sectional and prospective studies have shown 
      dioxins, PCBs, as well as PFASs to be linked to cardiovascular disease (CVD) and 
      mortality. In conclusion, as highlighted in this review, several lines of 
      evidence support the view that POPs of different chemical classes could be linked 
      to lipid abnormalities, carotid atherosclerosis and overt CVD like myocardial 
      infarction and stroke.
CI  - Copyright (c) 2020 The Korean Society of Lipid and Atherosclerosis.
FAU - Lind, P Monica
AU  - Lind PM
AUID- ORCID: 0000-0002-8949-3555
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Uppsala, Sweden.
FAU - Lind, Lars
AU  - Lind L
AUID- ORCID: 0000-0003-2335-8542
AD  - Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, 
      Uppsala, Sweden.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200805
PL  - Korea (South)
TA  - J Lipid Atheroscler
JT  - Journal of lipid and atherosclerosis
JID - 101610890
PMC - PMC7521972
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Cardiovascular diseases
OT  - Fatty liver
OT  - Lipids
OT  - Toxicology
COIS- Conflict of Interest: The authors have no conflicts of interest to declare.
EDAT- 2020/10/08 06:00
MHDA- 2020/10/08 06:01
PMCR- 2020/09/01
CRDT- 2020/10/07 05:51
PHST- 2020/06/12 00:00 [received]
PHST- 2020/07/15 00:00 [revised]
PHST- 2020/07/19 00:00 [accepted]
PHST- 2020/10/07 05:51 [entrez]
PHST- 2020/10/08 06:00 [pubmed]
PHST- 2020/10/08 06:01 [medline]
PHST- 2020/09/01 00:00 [pmc-release]
AID - 10.12997/jla.2020.9.3.334 [doi]
PST - ppublish
SO  - J Lipid Atheroscler. 2020 Sep;9(3):334-348. doi: 10.12997/jla.2020.9.3.334. Epub 
      2020 Aug 5.