PMID- 33027047
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221122
IS  - 1868-1891 (Electronic)
IS  - 1868-1883 (Linking)
VI  - 43
IP  - 2
DP  - 2020 Oct 6
TI  - Fertility in BRCA mutation carriers: counseling BRCA-mutated patients on 
      reproductive issues.
PG  - 171-177
LID - 10.1515/hmbci-2020-0005 [doi]
AB  - OBJECTIVES: Genetic testing rates for hereditary breast and ovarian cancer (HBOC) 
      have steadily increased during the past decades resulting in a growing population 
      of young and healthy mutation carriers. Available data on fertility issues in 
      BRCA mutation carriers is rising but the results remain to some extent still 
      conflicting. We have performed a systematic literature review in order to get an 
      overview concerning the current evidence on fertility issues in BRCA mutation 
      carriers. Data were analyzed critically with the aim to deliver physicians a 
      solid basis for (onco) fertility counseling in women with BRCA mutations. 
      CONTENT: We present the latest data on cancer risks in women with HBOC and 
      analyze the influence of cancer treatment and preventive surgery on the 
      reproductive potential. Epidemiological studies on fertility issues in BRCA 
      mutation carriers showed heterogeneous results. However, several authors showed a 
      decreased ovarian reserve with lower Anti-Mullerien hormone (AMH) levels and 
      poorer response to ovarian stimulation in BRCA positive women. The diagnosis of 
      BRCA mutations influences reproductive decision-making. Additionally, the 
      shortened reproductive window and the need to complete family planning early has 
      a significant psychological impact. SUMMARY AND OUTLOOK: This article highlights 
      the importance of fertility counseling in BRCA mutation carriers. Individual 
      fertility counseling is mandatory. Fertility preservation strategies should be 
      discussed.
CI  - (c) 2020 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Knabben, Laura
AU  - Knabben L
AD  - Department of Obstetrics and Gynaecology, University Hospital of Berne and 
      University of Berne, Berne, Switzerland.
FAU - Siegenthaler, Franziska
AU  - Siegenthaler F
AUID- ORCID: 0000-0002-3415-9162
AD  - Department of Obstetrics and Gynaecology, University Hospital of Berne and 
      University of Berne, Berne, Switzerland.
FAU - Imboden, Sara
AU  - Imboden S
AD  - Department of Obstetrics and Gynaecology, University Hospital of Berne and 
      University of Berne, Berne, Switzerland.
FAU - Mueller, Michael D
AU  - Mueller MD
AD  - Department of Obstetrics and Gynaecology, University Hospital of Berne and 
      University of Berne, Berne, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201006
PL  - Germany
TA  - Horm Mol Biol Clin Investig
JT  - Hormone molecular biology and clinical investigation
JID - 101538885
SB  - IM
OTO - NOTNLM
OT  - BRCA mutation carriers
OT  - fertility
OT  - hereditary breast and ovarian cancer syndrome
OT  - premature menopause
OT  - reproductive decisions
EDAT- 2020/10/08 06:00
MHDA- 2020/10/08 06:01
CRDT- 2020/10/07 17:12
PHST- 2020/01/20 00:00 [received]
PHST- 2020/08/24 00:00 [accepted]
PHST- 2020/10/08 06:00 [pubmed]
PHST- 2020/10/08 06:01 [medline]
PHST- 2020/10/07 17:12 [entrez]
AID - /j/hmbci.ahead-of-print/hmbci-2020-0005/hmbci-2020-0005.xml [pii]
AID - 10.1515/hmbci-2020-0005 [doi]
PST - epublish
SO  - Horm Mol Biol Clin Investig. 2020 Oct 6;43(2):171-177. doi: 
      10.1515/hmbci-2020-0005.