PMID- 33029737
OWN - NLM
STAT- MEDLINE
DCOM- 20211119
LR  - 20211119
IS  - 1559-1166 (Electronic)
IS  - 0895-8696 (Linking)
VI  - 71
IP  - 5
DP  - 2021 May
TI  - A review of the role of genetic factors in Guillain-Barre syndrome.
PG  - 902-920
LID - 10.1007/s12031-020-01720-7 [doi]
AB  - Guillain-Barre syndrome (GBS) is an acute inflammatory polyradiculoneuropathy 
      syndrome. Several genetic and environmental risk factors have been recognized for 
      GBS. AS GBS is an immune-related disorder, abnormal functions of T cells, 
      production of autoantibodies, and dysregulation of gene expression have been 
      detected in GBS patients. Based on the critical role of human leukocyte antigen 
      (HLA) in the regulation of immune responses, HLA alleles are among the mostly 
      investigated loci in GBS. A number of polymorphisms within different genes, 
      especially those linked with the regulation of immune responses, have been 
      associated with GBS in different populations. Moreover, several studies have 
      demonstrated abnormal expression of cytokine-coding genes in this disorder. 
      Investigations in the animal model of GBS have also verified the aberrant 
      regulation of Th1/Th2/Th17/Treg cytokines. In the current review, we describe the 
      information about the role of these factors in GBS.
FAU - Safa, Amin
AU  - Safa A
AD  - Institute of Research and Development, Duy Tan University, Da Nang, 550000, Viet 
      Nam.
FAU - Azimi, Tahereh
AU  - Azimi T
AD  - Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Sayad, Arezou
AU  - Sayad A
AD  - Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Taheri, Mohammad
AU  - Taheri M
AUID- ORCID: 0000-0001-8381-0591
AD  - Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran. mohammad_823@yahoo.com.
FAU - Ghafouri-Fard, Soudeh
AU  - Ghafouri-Fard S
AD  - Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran. S.ghafourifard@sbmu.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201007
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Cytokines)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Animals
MH  - Cytokines/genetics/metabolism
MH  - Guillain-Barre Syndrome/*genetics/immunology
MH  - HLA Antigens/genetics
MH  - Humans
MH  - *Polymorphism, Genetic
OTO - NOTNLM
OT  - Genetic
OT  - Guillain-Barre syndrome
OT  - HLA
OT  - Polymorphism
EDAT- 2020/10/09 06:00
MHDA- 2021/11/20 06:00
CRDT- 2020/10/08 05:35
PHST- 2020/08/23 00:00 [received]
PHST- 2020/09/24 00:00 [accepted]
PHST- 2020/10/09 06:00 [pubmed]
PHST- 2021/11/20 06:00 [medline]
PHST- 2020/10/08 05:35 [entrez]
AID - 10.1007/s12031-020-01720-7 [pii]
AID - 10.1007/s12031-020-01720-7 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2021 May;71(5):902-920. doi: 10.1007/s12031-020-01720-7. Epub 
      2020 Oct 7.