PMID- 33030766
OWN - NLM
STAT- MEDLINE
DCOM- 20211208
LR  - 20221005
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 42
IP  - 2
DP  - 2021 Feb 1
TI  - Childhood trauma is associated with elevated anhedonia and altered core reward 
      circuitry in major depression patients and controls.
PG  - 286-297
LID - 10.1002/hbm.25222 [doi]
AB  - Childhood trauma (CT) is a well-established risk factor for major depressive 
      disorder (MDD). However, the underlying mechanism linking CT and MDD remains not 
      fully understood. The present study tested the hypothesis that CT have effects on 
      specific types of anhedonia in depression via reward system. To do so, we 
      evaluated different aspects of anhedonia and resting-state functional 
      connectivity (FC) in reward system among 66 patients with MDD (44 with 
      moderate-to-severe and 22 with no or low CT), and 57 healthy controls (HC; 23 
      with moderate-to-severe and 34 with no or low CT). Results showed that MDD 
      patients with moderate-to-severe CT suffered more severe state anhedonic 
      depression than patients with no or low level of CT. Individuals with 
      moderate-to-severe CT, irrespective of MDD diagnosis, had elevated physical, 
      social and anticipatory but not consummatory trait anhedonia, and demonstrated 
      decreased left nucleus accumbens (NAcc)-right orbital frontal cortex (OFC) and 
      left ventral caudate-left OFC connectivity compared to those with no or low 
      exposure. Left NAcc-right OFC connectivity mediated relationship between CT and 
      state anhedonia in MDD. The total altered ventral striatum (VS)-OFC connectivity 
      mediated links between CT and physical trait anhedonia in HC. These findings 
      highlight specific types of anhedonia and the core reward system as targets of 
      CT. Blunted hedonic responses via decreased coupling within core reward system 
      may be involved in the mechanism of depression following CT. Implications for 
      clinical interventions are also discussed.
CI  - (c) 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
FAU - Fan, Jie
AU  - Fan J
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, Changsha, Hunan, China.
AD  - Medical Psychological Institute, Central South University, Changsha, Hunan, 
      China.
AD  - National Clinical Research Center for Mental Disorders, Changsha, Hunan, China.
FAU - Liu, Wanting
AU  - Liu W
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, Changsha, Hunan, China.
FAU - Xia, Jie
AU  - Xia J
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, Changsha, Hunan, China.
FAU - Li, Sihui
AU  - Li S
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, Changsha, Hunan, China.
FAU - Gao, Feng
AU  - Gao F
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, Changsha, Hunan, China.
FAU - Zhu, Jiang
AU  - Zhu J
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, Changsha, Hunan, China.
FAU - Han, Yan
AU  - Han Y
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, Changsha, Hunan, China.
FAU - Zhou, Huan
AU  - Zhou H
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, Changsha, Hunan, China.
FAU - Liao, Haiyan
AU  - Liao H
AD  - Department of Radiology, The Second Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Yi, Jinyao
AU  - Yi J
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, Changsha, Hunan, China.
FAU - Tan, Changlian
AU  - Tan C
AD  - Department of Radiology, The Second Xiangya Hospital, Central South University, 
      Changsha, Hunan, China.
FAU - Zhu, Xiongzhao
AU  - Zhu X
AUID- ORCID: 0000-0002-0153-7163
AD  - Medical Psychological Center, The Second Xiangya Hospital, Central South 
      University, Changsha, Hunan, China.
AD  - Medical Psychological Institute, Central South University, Changsha, Hunan, 
      China.
AD  - National Clinical Research Center for Mental Disorders, Changsha, Hunan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201008
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Adverse Childhood Experiences/psychology/*trends
MH  - Anhedonia/*physiology
MH  - Brain/*diagnostic imaging
MH  - Caudate Nucleus/diagnostic imaging
MH  - Depressive Disorder, Major/*diagnostic imaging/psychology
MH  - Female
MH  - Frontal Lobe/diagnostic imaging
MH  - Humans
MH  - Male
MH  - Nerve Net/*diagnostic imaging
MH  - Nucleus Accumbens/diagnostic imaging
MH  - Retrospective Studies
MH  - *Reward
MH  - Young Adult
PMC - PMC7775998
OTO - NOTNLM
OT  - Anhedonia
OT  - childhood trauma
OT  - depression
OT  - resting-state functional connectivity
OT  - reward circuit
COIS- The authors declare no conflict of interest.
EDAT- 2020/10/09 06:00
MHDA- 2021/12/15 06:00
PMCR- 2020/10/08
CRDT- 2020/10/08 12:24
PHST- 2019/09/12 00:00 [received]
PHST- 2020/09/15 00:00 [revised]
PHST- 2020/09/22 00:00 [accepted]
PHST- 2020/10/09 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/10/08 12:24 [entrez]
PHST- 2020/10/08 00:00 [pmc-release]
AID - HBM25222 [pii]
AID - 10.1002/hbm.25222 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2021 Feb 1;42(2):286-297. doi: 10.1002/hbm.25222. Epub 2020 Oct 
      8.